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Clinicopathologic study associated with long-term survival in Japanese patients with node-negative breast cancer.
Br J Cancer. 2000 Jan; 82(2):404-11.BJ

Abstract

This study was undertaken to determine the absolute and relative value of blood vessel invasion (BVI) using both factor VIII-related antigen and elastica van Gieson staining, proliferating cell nuclear antigen (PCNA), p53, c-erbB-2, and conventional prognostic factors in predicting relapse-free survival (RFS) and overall survival (OS) rates associated with long-term survival in Japanese patients with node-negative breast cancer. Two hundred patients with histological node-negative breast cancer were studied. We investigated nine clinicopathological factors, including PCNA, p53, c-erbB-2 using permanent-section immunohistochemistry, clinical tumour size (T), histological grade (HG), mitotic index (MI), tumour necrosis (TN), lymphatic vessel invasion (LVI) and BVI, followed for a median of 10 years (range 1-20). Twenty-one patients (10.5%) had recurrence and 15 patients (7.5%) died of breast cancer. Univariate analysis showed that BVI, PCNA, T, HG, MI, p53, c-erbB-2 and LVI were significantly predictive of 20-year RFS or OS. Multivariate analysis showed that BVI (P = 0.0159, P = 0.0368), proliferating cell nuclear antigen (PCNA) (P = 0.0165, P = 0.0001), and T (P = 0.0190, P = 0.0399) were significantly independent prognostic factors for RFS or OS respectively. BVI, PCNA and T were independent prognostic indicators for RFS or OS in Japanese patients with node-negative breast cancer and are useful in selecting high-risk patients who may be eligible to receive strong adjuvant therapies.

Authors+Show Affiliations

Department of Surgery II, School of Medicine, Tokyo Women's Medical University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10646896

Citation

Kato, T, et al. "Clinicopathologic Study Associated With Long-term Survival in Japanese Patients With Node-negative Breast Cancer." British Journal of Cancer, vol. 82, no. 2, 2000, pp. 404-11.
Kato T, Kimura T, Miyakawa R, et al. Clinicopathologic study associated with long-term survival in Japanese patients with node-negative breast cancer. Br J Cancer. 2000;82(2):404-11.
Kato, T., Kimura, T., Miyakawa, R., Fujii, A., Yamamoto, K., Kameoka, S., Nishikawa, T., & Kasajima, T. (2000). Clinicopathologic study associated with long-term survival in Japanese patients with node-negative breast cancer. British Journal of Cancer, 82(2), 404-11.
Kato T, et al. Clinicopathologic Study Associated With Long-term Survival in Japanese Patients With Node-negative Breast Cancer. Br J Cancer. 2000;82(2):404-11. PubMed PMID: 10646896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinicopathologic study associated with long-term survival in Japanese patients with node-negative breast cancer. AU - Kato,T, AU - Kimura,T, AU - Miyakawa,R, AU - Fujii,A, AU - Yamamoto,K, AU - Kameoka,S, AU - Nishikawa,T, AU - Kasajima,T, PY - 2000/1/26/pubmed PY - 2000/1/26/medline PY - 2000/1/26/entrez SP - 404 EP - 11 JF - British journal of cancer JO - Br J Cancer VL - 82 IS - 2 N2 - This study was undertaken to determine the absolute and relative value of blood vessel invasion (BVI) using both factor VIII-related antigen and elastica van Gieson staining, proliferating cell nuclear antigen (PCNA), p53, c-erbB-2, and conventional prognostic factors in predicting relapse-free survival (RFS) and overall survival (OS) rates associated with long-term survival in Japanese patients with node-negative breast cancer. Two hundred patients with histological node-negative breast cancer were studied. We investigated nine clinicopathological factors, including PCNA, p53, c-erbB-2 using permanent-section immunohistochemistry, clinical tumour size (T), histological grade (HG), mitotic index (MI), tumour necrosis (TN), lymphatic vessel invasion (LVI) and BVI, followed for a median of 10 years (range 1-20). Twenty-one patients (10.5%) had recurrence and 15 patients (7.5%) died of breast cancer. Univariate analysis showed that BVI, PCNA, T, HG, MI, p53, c-erbB-2 and LVI were significantly predictive of 20-year RFS or OS. Multivariate analysis showed that BVI (P = 0.0159, P = 0.0368), proliferating cell nuclear antigen (PCNA) (P = 0.0165, P = 0.0001), and T (P = 0.0190, P = 0.0399) were significantly independent prognostic factors for RFS or OS respectively. BVI, PCNA and T were independent prognostic indicators for RFS or OS in Japanese patients with node-negative breast cancer and are useful in selecting high-risk patients who may be eligible to receive strong adjuvant therapies. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/10646896/Clinicopathologic_study_associated_with_long_term_survival_in_Japanese_patients_with_node_negative_breast_cancer_ L2 - https://doi.org/10.1054/bjoc.1999.0934 DB - PRIME DP - Unbound Medicine ER -