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Hereditary colorectal cancer: clinical consequences of predictive molecular testing.
Int J Colorectal Dis 1999; 14(4-5):184-93IJ

Abstract

The continuing increase in knowledge about the genetic basis of carcinogenesis has led to diverse efforts to exploit this knowledge clinically, primarily in the form of predictive genetic testing. In conjunction with family history, gene tests are intended to improve individual cancer risk assessment. The objectives of predictive molecular testing are to identify the disease-causing germline mutation in an index person who has already developed the disease and to distinguish asymptomatic mutation carriers from non-mutation carriers within a given cancer-prone family. At present, genetic testing for colorectal cancer risk, primarily in form of DNA sequencing, is applied in familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC). In these inherited colorectal tumor syndromes determining the genetic status may result in an individually tailored surveillance program and prophylactic treatment. The implications of genetic testing for the clinical management of disease, both of mutation and non-mutation carriers, in familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer families are discussed.

Authors+Show Affiliations

Chirurgische Forschung, Universitätsklinikum Carl Gustav Carus, Dresden, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10647626

Citation

Hahn, M, et al. "Hereditary Colorectal Cancer: Clinical Consequences of Predictive Molecular Testing." International Journal of Colorectal Disease, vol. 14, no. 4-5, 1999, pp. 184-93.
Hahn M, Saeger HD, Schackert HK. Hereditary colorectal cancer: clinical consequences of predictive molecular testing. Int J Colorectal Dis. 1999;14(4-5):184-93.
Hahn, M., Saeger, H. D., & Schackert, H. K. (1999). Hereditary colorectal cancer: clinical consequences of predictive molecular testing. International Journal of Colorectal Disease, 14(4-5), pp. 184-93.
Hahn M, Saeger HD, Schackert HK. Hereditary Colorectal Cancer: Clinical Consequences of Predictive Molecular Testing. Int J Colorectal Dis. 1999;14(4-5):184-93. PubMed PMID: 10647626.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hereditary colorectal cancer: clinical consequences of predictive molecular testing. AU - Hahn,M, AU - Saeger,H D, AU - Schackert,H K, PY - 2000/1/27/pubmed PY - 2000/2/26/medline PY - 2000/1/27/entrez SP - 184 EP - 93 JF - International journal of colorectal disease JO - Int J Colorectal Dis VL - 14 IS - 4-5 N2 - The continuing increase in knowledge about the genetic basis of carcinogenesis has led to diverse efforts to exploit this knowledge clinically, primarily in the form of predictive genetic testing. In conjunction with family history, gene tests are intended to improve individual cancer risk assessment. The objectives of predictive molecular testing are to identify the disease-causing germline mutation in an index person who has already developed the disease and to distinguish asymptomatic mutation carriers from non-mutation carriers within a given cancer-prone family. At present, genetic testing for colorectal cancer risk, primarily in form of DNA sequencing, is applied in familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC). In these inherited colorectal tumor syndromes determining the genetic status may result in an individually tailored surveillance program and prophylactic treatment. The implications of genetic testing for the clinical management of disease, both of mutation and non-mutation carriers, in familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer families are discussed. SN - 0179-1958 UR - https://www.unboundmedicine.com/medline/citation/10647626/Hereditary_colorectal_cancer:_clinical_consequences_of_predictive_molecular_testing_ L2 - http://www.diseaseinfosearch.org/result/3345 DB - PRIME DP - Unbound Medicine ER -