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Diagnostic evaluation of hyperprolactinemia.
J Reprod Med. 1999 Dec; 44(12 Suppl):1095-9.JR

Abstract

A serum prolactin (PRL) level is obtained in response to a specific clinical presentation, including symptoms of hyperprolactinemia (such as amenorrhea and galactorrhea); serum PRL measurement may also be performed as part of an infertility evaluation. An initial level above the normal range should be followed by a repeat level from a blood sample drawn in the morning with the patient in a fasting state. The medical history and a few laboratory tests can eliminate the most common physiologic and pharmacologic causes of hyperprolactinemia, including pregnancy, primary hypothyroidism and treatment with drugs (such as neuroleptics) that reduce dopaminergic effects on the pituitary. In the absence of such causes, radiologic imaging of the sella turcica is necessary to establish whether a PRL-secreting pituitary adenoma or other lesion is present. The vast majority of patients are treated medically, with dopamine agonist drugs. Surgery is reserved for the patient with the uncommon tumor that does not respond to medical therapy or has a large cystic component or for the occasional patient who cannot tolerate dopamine agonists or who experiences pituitary apoplexy.

Authors+Show Affiliations

Neuroendocrine Unit, Massachusetts General Hospital, Boston 02114, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10649817

Citation

Biller, B M.. "Diagnostic Evaluation of Hyperprolactinemia." The Journal of Reproductive Medicine, vol. 44, no. 12 Suppl, 1999, pp. 1095-9.
Biller BM. Diagnostic evaluation of hyperprolactinemia. J Reprod Med. 1999;44(12 Suppl):1095-9.
Biller, B. M. (1999). Diagnostic evaluation of hyperprolactinemia. The Journal of Reproductive Medicine, 44(12 Suppl), 1095-9.
Biller BM. Diagnostic Evaluation of Hyperprolactinemia. J Reprod Med. 1999;44(12 Suppl):1095-9. PubMed PMID: 10649817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic evaluation of hyperprolactinemia. A1 - Biller,B M, PY - 2000/1/29/pubmed PY - 2000/1/29/medline PY - 2000/1/29/entrez SP - 1095 EP - 9 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 44 IS - 12 Suppl N2 - A serum prolactin (PRL) level is obtained in response to a specific clinical presentation, including symptoms of hyperprolactinemia (such as amenorrhea and galactorrhea); serum PRL measurement may also be performed as part of an infertility evaluation. An initial level above the normal range should be followed by a repeat level from a blood sample drawn in the morning with the patient in a fasting state. The medical history and a few laboratory tests can eliminate the most common physiologic and pharmacologic causes of hyperprolactinemia, including pregnancy, primary hypothyroidism and treatment with drugs (such as neuroleptics) that reduce dopaminergic effects on the pituitary. In the absence of such causes, radiologic imaging of the sella turcica is necessary to establish whether a PRL-secreting pituitary adenoma or other lesion is present. The vast majority of patients are treated medically, with dopamine agonist drugs. Surgery is reserved for the patient with the uncommon tumor that does not respond to medical therapy or has a large cystic component or for the occasional patient who cannot tolerate dopamine agonists or who experiences pituitary apoplexy. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/10649817/Diagnostic_evaluation_of_hyperprolactinemia_ L2 - http://www.diseaseinfosearch.org/result/2971 DB - PRIME DP - Unbound Medicine ER -