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The role of tobacco, snuff and alcohol use in the aetiology of cancer of the oesophagus and gastric cardia.
Int J Cancer 2000; 85(3):340-6IJ

Abstract

While tobacco and alcohol are established risk factors for oesophageal squamous-cell carcinoma, their roles in the aetiology of the increasingly common oesophageal adenocarcinoma remains uncertain. We tested the association between tobacco, snuff and alcohol use and the risk of oesophageal and cardia cancer in a nationwide, population-based case-control study in Sweden. Face-to-face interviews were conducted with 618 (81% of all eligible) patients (189 oesophageal adenocarcinoma, 262 cardia adenocarcinoma and 167 oesophageal squamous-cell carcinoma) and 820 control subjects. Odds ratios (OR) were calculated by logistic regression with multivariate adjustments for potential confounding. The risk of oesophageal adenocarcinoma was not associated with snuff or alcohol use, and the association with smoking was weak or absent. Gastric cardia adenocarcinoma was dose-dependently associated with smoking (OR=4.2, 95% CI=2.5-7.0 among heavy smokers compared with never-smokers), but not with alcohol or snuff use. Oesophageal squamous-cell carcinoma was strongly associated with tobacco, moderately with alcohol, but not with snuff use; combined use of tobacco and alcohol entailed a strongly increased risk (OR=23.1, 95% CI=9.6-56.0 among heavy users compared with never-users). We conclude that tobacco smoking, a strong risk factor for oesophageal squamous-cell carcinoma and cardia adenocarcinoma, does not play an important role in the aetiology of oesophageal adenocarcinoma. None of the studied exposures can explain the increasing incidence of oesophageal adenocarcinoma.

Authors+Show Affiliations

Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10652424

Citation

Lagergren, J, et al. "The Role of Tobacco, Snuff and Alcohol Use in the Aetiology of Cancer of the Oesophagus and Gastric Cardia." International Journal of Cancer, vol. 85, no. 3, 2000, pp. 340-6.
Lagergren J, Bergström R, Lindgren A, et al. The role of tobacco, snuff and alcohol use in the aetiology of cancer of the oesophagus and gastric cardia. Int J Cancer. 2000;85(3):340-6.
Lagergren, J., Bergström, R., Lindgren, A., & Nyrén, O. (2000). The role of tobacco, snuff and alcohol use in the aetiology of cancer of the oesophagus and gastric cardia. International Journal of Cancer, 85(3), pp. 340-6.
Lagergren J, et al. The Role of Tobacco, Snuff and Alcohol Use in the Aetiology of Cancer of the Oesophagus and Gastric Cardia. Int J Cancer. 2000 Feb 1;85(3):340-6. PubMed PMID: 10652424.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of tobacco, snuff and alcohol use in the aetiology of cancer of the oesophagus and gastric cardia. AU - Lagergren,J, AU - Bergström,R, AU - Lindgren,A, AU - Nyrén,O, PY - 2000/2/1/pubmed PY - 2000/3/11/medline PY - 2000/2/1/entrez SP - 340 EP - 6 JF - International journal of cancer JO - Int. J. Cancer VL - 85 IS - 3 N2 - While tobacco and alcohol are established risk factors for oesophageal squamous-cell carcinoma, their roles in the aetiology of the increasingly common oesophageal adenocarcinoma remains uncertain. We tested the association between tobacco, snuff and alcohol use and the risk of oesophageal and cardia cancer in a nationwide, population-based case-control study in Sweden. Face-to-face interviews were conducted with 618 (81% of all eligible) patients (189 oesophageal adenocarcinoma, 262 cardia adenocarcinoma and 167 oesophageal squamous-cell carcinoma) and 820 control subjects. Odds ratios (OR) were calculated by logistic regression with multivariate adjustments for potential confounding. The risk of oesophageal adenocarcinoma was not associated with snuff or alcohol use, and the association with smoking was weak or absent. Gastric cardia adenocarcinoma was dose-dependently associated with smoking (OR=4.2, 95% CI=2.5-7.0 among heavy smokers compared with never-smokers), but not with alcohol or snuff use. Oesophageal squamous-cell carcinoma was strongly associated with tobacco, moderately with alcohol, but not with snuff use; combined use of tobacco and alcohol entailed a strongly increased risk (OR=23.1, 95% CI=9.6-56.0 among heavy users compared with never-users). We conclude that tobacco smoking, a strong risk factor for oesophageal squamous-cell carcinoma and cardia adenocarcinoma, does not play an important role in the aetiology of oesophageal adenocarcinoma. None of the studied exposures can explain the increasing incidence of oesophageal adenocarcinoma. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/10652424/The_role_of_tobacco_snuff_and_alcohol_use_in_the_aetiology_of_cancer_of_the_oesophagus_and_gastric_cardia_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0020-7136&date=2000&volume=85&issue=3&spage=340 DB - PRIME DP - Unbound Medicine ER -