Tags

Type your tag names separated by a space and hit enter

Evaluation of microsatellite markers for efficient assessment of high microsatellite instabile colorectal tumors.
Pflugers Arch. 2000; 439(3 Suppl):R47-9.PA

Abstract

Two hundred thirty randomly collected primary colorectal tumors were initially screened for microsatellite instability (MSI) with three highly informative microsatellite markers (BAT26, D2S123 and D5S346). Forty one (17.8%) tumors showed alterations in at least one marker. In further MSI analysis of these 41 MSI tumors with additional 9 markers, 21 tumors (9.6% of 230 analyzed) exhibited MSI at more than 40% and the rest 20 (8.7% of 230 analyzed) tumors exhibited MSI at 8%-20% tested markers. These results support classification of MSI tumors into high MSI tumors (more than 40% unstable loci) and low MSI tumors (less than 20% unstable loci). Based on our results the combination of BAT26 and two out of four other highly informative markers (D2S123, D5S346, BAT25 or BAT40) is recommended for rapid and reliable assessment of high MSI tumors.

Authors+Show Affiliations

Laboratory of Molecular Genetics, Institute of Pathology, Medical Faculty, Ljubljana, Slovenia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10653139

Citation

Potocnik, U, et al. "Evaluation of Microsatellite Markers for Efficient Assessment of High Microsatellite Instabile Colorectal Tumors." Pflugers Archiv : European Journal of Physiology, vol. 439, no. 3 Suppl, 2000, pp. R47-9.
Potocnik U, Glavac D, Golouh R, et al. Evaluation of microsatellite markers for efficient assessment of high microsatellite instabile colorectal tumors. Pflugers Arch. 2000;439(3 Suppl):R47-9.
Potocnik, U., Glavac, D., Golouh, R., & Ravnik-Glavac, M. (2000). Evaluation of microsatellite markers for efficient assessment of high microsatellite instabile colorectal tumors. Pflugers Archiv : European Journal of Physiology, 439(3 Suppl), R47-9.
Potocnik U, et al. Evaluation of Microsatellite Markers for Efficient Assessment of High Microsatellite Instabile Colorectal Tumors. Pflugers Arch. 2000;439(3 Suppl):R47-9. PubMed PMID: 10653139.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of microsatellite markers for efficient assessment of high microsatellite instabile colorectal tumors. AU - Potocnik,U, AU - Glavac,D, AU - Golouh,R, AU - Ravnik-Glavac,M, PY - 2000/2/1/pubmed PY - 2000/2/19/medline PY - 2000/2/1/entrez SP - R47 EP - 9 JF - Pflugers Archiv : European journal of physiology JO - Pflugers Arch VL - 439 IS - 3 Suppl N2 - Two hundred thirty randomly collected primary colorectal tumors were initially screened for microsatellite instability (MSI) with three highly informative microsatellite markers (BAT26, D2S123 and D5S346). Forty one (17.8%) tumors showed alterations in at least one marker. In further MSI analysis of these 41 MSI tumors with additional 9 markers, 21 tumors (9.6% of 230 analyzed) exhibited MSI at more than 40% and the rest 20 (8.7% of 230 analyzed) tumors exhibited MSI at 8%-20% tested markers. These results support classification of MSI tumors into high MSI tumors (more than 40% unstable loci) and low MSI tumors (less than 20% unstable loci). Based on our results the combination of BAT26 and two out of four other highly informative markers (D2S123, D5S346, BAT25 or BAT40) is recommended for rapid and reliable assessment of high MSI tumors. SN - 0031-6768 UR - https://www.unboundmedicine.com/medline/citation/10653139/Evaluation_of_microsatellite_markers_for_efficient_assessment_of_high_microsatellite_instabile_colorectal_tumors_ L2 - https://medlineplus.gov/colorectalcancer.html DB - PRIME DP - Unbound Medicine ER -