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Effects of dietary n-3 polyunsaturated fatty acids from plant and marine origin on platelet aggregation in healthy elderly subjects.
Br J Nutr. 1999 Sep; 82(3):183-91.BJ

Abstract

In the present intervention study we compared the effects of alpha-linolenic acid with those of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on platelet aggregation in vitro and ex vivo in healthy non-institutionalized elderly subjects. We also compared the effects of alpha-linolenic acid on platelet aggregation in elderly subjects with those in younger volunteers. During a run-in period of 3 weeks all subjects (thirty-eight elderly (> 60 years) and twelve younger volunteers (< 35 years)) received a diet rich in oleic acid. For the next 6 weeks the elderly subjects received a diet rich in oleic acid (n 11), alpha-linolenic acid (n 14) (6.8 g/d) or EPA/DHA (n 13) (1.05 g EPA plus 0.55 g DHA). The younger subjects were given a diet rich in alpha-linolenic acid. The diets did not affect ADP- or collagen-induced platelet aggregation in vitro in either platelet-rich plasma or whole blood. The ex vivo platelet aggregation as measured with filtragometry was significantly decreased in the elderly group that received EPA/DHA compared with the alpha-linolenic acid (P = 0.006) and the oleic acid (P = 0.005) diet groups. Effects of alpha-linolenic acid were not age-dependent. Our results suggest that alpha-linolenic acid and EPA/DHA do not change in vitro platelet aggregation. Compared with oleic acid, EPA/DHA, but not alpha-linolenic acid, favourably affects ex vivo platelet aggregation in healthy elderly subjects.

Authors+Show Affiliations

Department of Human Biology, Maastricht University, The Netherlands.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10655965

Citation

Wensing, A G., et al. "Effects of Dietary N-3 Polyunsaturated Fatty Acids From Plant and Marine Origin On Platelet Aggregation in Healthy Elderly Subjects." The British Journal of Nutrition, vol. 82, no. 3, 1999, pp. 183-91.
Wensing AG, Mensink RP, Hornstra G. Effects of dietary n-3 polyunsaturated fatty acids from plant and marine origin on platelet aggregation in healthy elderly subjects. Br J Nutr. 1999;82(3):183-91.
Wensing, A. G., Mensink, R. P., & Hornstra, G. (1999). Effects of dietary n-3 polyunsaturated fatty acids from plant and marine origin on platelet aggregation in healthy elderly subjects. The British Journal of Nutrition, 82(3), 183-91.
Wensing AG, Mensink RP, Hornstra G. Effects of Dietary N-3 Polyunsaturated Fatty Acids From Plant and Marine Origin On Platelet Aggregation in Healthy Elderly Subjects. Br J Nutr. 1999;82(3):183-91. PubMed PMID: 10655965.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dietary n-3 polyunsaturated fatty acids from plant and marine origin on platelet aggregation in healthy elderly subjects. AU - Wensing,A G, AU - Mensink,R P, AU - Hornstra,G, PY - 2000/2/3/pubmed PY - 2000/2/19/medline PY - 2000/2/3/entrez SP - 183 EP - 91 JF - The British journal of nutrition JO - Br J Nutr VL - 82 IS - 3 N2 - In the present intervention study we compared the effects of alpha-linolenic acid with those of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on platelet aggregation in vitro and ex vivo in healthy non-institutionalized elderly subjects. We also compared the effects of alpha-linolenic acid on platelet aggregation in elderly subjects with those in younger volunteers. During a run-in period of 3 weeks all subjects (thirty-eight elderly (> 60 years) and twelve younger volunteers (< 35 years)) received a diet rich in oleic acid. For the next 6 weeks the elderly subjects received a diet rich in oleic acid (n 11), alpha-linolenic acid (n 14) (6.8 g/d) or EPA/DHA (n 13) (1.05 g EPA plus 0.55 g DHA). The younger subjects were given a diet rich in alpha-linolenic acid. The diets did not affect ADP- or collagen-induced platelet aggregation in vitro in either platelet-rich plasma or whole blood. The ex vivo platelet aggregation as measured with filtragometry was significantly decreased in the elderly group that received EPA/DHA compared with the alpha-linolenic acid (P = 0.006) and the oleic acid (P = 0.005) diet groups. Effects of alpha-linolenic acid were not age-dependent. Our results suggest that alpha-linolenic acid and EPA/DHA do not change in vitro platelet aggregation. Compared with oleic acid, EPA/DHA, but not alpha-linolenic acid, favourably affects ex vivo platelet aggregation in healthy elderly subjects. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/10655965/Effects_of_dietary_n_3_polyunsaturated_fatty_acids_from_plant_and_marine_origin_on_platelet_aggregation_in_healthy_elderly_subjects_ L2 - https://www.cambridge.org/core/product/identifier/S0007114599001361/type/journal_article DB - PRIME DP - Unbound Medicine ER -