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Effects of dietary fats (fish, olive and high-oleic-acid sunflower oils) on lipid composition and antioxidant enzymes in rat liver.
Br J Nutr. 1999 Sep; 82(3):233-41.BJ

Abstract

The effects of two oleic-acid-rich diets (containing olive oil, OO, and high-oleic-acid sunflower oil, HOSO) on plasma and liver lipid composition detoxification enzyme activities, were compared with those of a fish-oil (FO) diet and a control diet. Compared with the control diet, plasma and hepatic total triacylglycerol concentrations were increased in the animals fed on the HOSO and OO diets and decreased in those fed on the FO diet. The animals fed on FO showed the highest level of cholesterol in the liver and had lower plasma cholesterol concentrations when compared with those fed on the two oleic-acid-rich diets. In comparison with the animals fed on the diets enriched in oleic acid, the FO group showed higher hepatic levels of polyunsaturated fatty acids of the n-3 series and lower levels of fatty acids of the n-6 series. Livers of FO-fed rats, compared with those of OO- and HOSO-fed rats showed: (1) significantly higher activities of catalase (EC 1.11.1.6) glutathione peroxidase (EC 1.11.1.9) and Cu/Zn superoxide dismutase (EC 1.15.1.1); (2) no differences in the NADPH-cytochrome c reductase (EC 1.6.99.3) activity. The HOSO diet had a similar effect on liver antioxidant enzyme activities as the OO diet. In conclusion, it appears that changes in the liver fatty acid composition due mainly to n-3 lipids may enhance the efficiency of the antioxidant defence system. The two monounsaturated fatty acids oils studied (OO and HOSO), with the same high content of oleic acid but different contents of natural antioxidants, had similar effects on the antioxidant enzyme activities measured.

Authors+Show Affiliations

Instituto de la Grasa y sus Derivados, CSIC, Sevilla, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10655970

Citation

Ruiz-Gutiérrez, V, et al. "Effects of Dietary Fats (fish, Olive and High-oleic-acid Sunflower Oils) On Lipid Composition and Antioxidant Enzymes in Rat Liver." The British Journal of Nutrition, vol. 82, no. 3, 1999, pp. 233-41.
Ruiz-Gutiérrez V, Pérez-Espinosa A, Vázquez CM, et al. Effects of dietary fats (fish, olive and high-oleic-acid sunflower oils) on lipid composition and antioxidant enzymes in rat liver. Br J Nutr. 1999;82(3):233-41.
Ruiz-Gutiérrez, V., Pérez-Espinosa, A., Vázquez, C. M., & Santa-María, C. (1999). Effects of dietary fats (fish, olive and high-oleic-acid sunflower oils) on lipid composition and antioxidant enzymes in rat liver. The British Journal of Nutrition, 82(3), 233-41.
Ruiz-Gutiérrez V, et al. Effects of Dietary Fats (fish, Olive and High-oleic-acid Sunflower Oils) On Lipid Composition and Antioxidant Enzymes in Rat Liver. Br J Nutr. 1999;82(3):233-41. PubMed PMID: 10655970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dietary fats (fish, olive and high-oleic-acid sunflower oils) on lipid composition and antioxidant enzymes in rat liver. AU - Ruiz-Gutiérrez,V, AU - Pérez-Espinosa,A, AU - Vázquez,C M, AU - Santa-María,C, PY - 2000/2/3/pubmed PY - 2000/2/19/medline PY - 2000/2/3/entrez SP - 233 EP - 41 JF - The British journal of nutrition JO - Br J Nutr VL - 82 IS - 3 N2 - The effects of two oleic-acid-rich diets (containing olive oil, OO, and high-oleic-acid sunflower oil, HOSO) on plasma and liver lipid composition detoxification enzyme activities, were compared with those of a fish-oil (FO) diet and a control diet. Compared with the control diet, plasma and hepatic total triacylglycerol concentrations were increased in the animals fed on the HOSO and OO diets and decreased in those fed on the FO diet. The animals fed on FO showed the highest level of cholesterol in the liver and had lower plasma cholesterol concentrations when compared with those fed on the two oleic-acid-rich diets. In comparison with the animals fed on the diets enriched in oleic acid, the FO group showed higher hepatic levels of polyunsaturated fatty acids of the n-3 series and lower levels of fatty acids of the n-6 series. Livers of FO-fed rats, compared with those of OO- and HOSO-fed rats showed: (1) significantly higher activities of catalase (EC 1.11.1.6) glutathione peroxidase (EC 1.11.1.9) and Cu/Zn superoxide dismutase (EC 1.15.1.1); (2) no differences in the NADPH-cytochrome c reductase (EC 1.6.99.3) activity. The HOSO diet had a similar effect on liver antioxidant enzyme activities as the OO diet. In conclusion, it appears that changes in the liver fatty acid composition due mainly to n-3 lipids may enhance the efficiency of the antioxidant defence system. The two monounsaturated fatty acids oils studied (OO and HOSO), with the same high content of oleic acid but different contents of natural antioxidants, had similar effects on the antioxidant enzyme activities measured. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/10655970/Effects_of_dietary_fats__fish_olive_and_high_oleic_acid_sunflower_oils__on_lipid_composition_and_antioxidant_enzymes_in_rat_liver_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -