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Spreads enriched with plant sterols, either esterified 4,4-dimethylsterols or free 4-desmethylsterols, and plasma total- and LDL-cholesterol concentrations.
Br J Nutr. 1999 Oct; 82(4):273-82.BJ

Abstract

In a 9-week study seventy-six healthy adult volunteers with an average age of 44 (SD 11) years, with baseline plasma total cholesterol levels below 8 mmol/l, received in a balanced, double-blind, crossover design, a total of three different table spreads for personal use. Two spreads were fortified either with free (non-esterified) vegetable-oil sterols, mainly from soyabean oil (31 g sterol equivalents/kg; 0.8 g/d) or sheanut-oil sterols (133 g sterol equivalents/kg; 3.3 g/d). One spread was not fortified (control). Average intake of spread was 25 g/d for 3 weeks. None of the spreads induced changes in blood clinical chemistry or haematology. Plasma total- and LDL-cholesterol concentrations were statistically significantly reduced by 3.8% and 6% (both 0.19 mmol/l) respectively, for the spread enriched with free soyabean-oil sterols compared with the control spread. The spread enriched with sheanut-oil sterols did not lower plasma total- and LDL-cholesterol levels. None of the plant-sterol-enriched spreads affected plasma HDL-cholesterol concentrations. Plasma-lipid-standardized concentrations of alpha- plus beta-carotene were not statistically significantly affected by the soyabean-oil sterol spread in contrast to lipid-standardized plasma lycopene levels which showed a statistically significant decrease (9.5%). These findings indicate that a daily intake of free soyabean-oil sterols as low as 0.8 g added to a spread is effective in lowering blood total- and LDL-cholesterol levels with limited effects on blood carotenoid levels. The lowering in total- and LDL-cholesterol blood levels due to consumption of the vegetable-oil-sterol-enriched spread may be helpful in reducing the risk of CHD for the population.

Authors+Show Affiliations

Unilever Nutrition Centre, Unilever Research Vlaardingen, The Netherlands.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

10655976

Citation

Sierksma, A, et al. "Spreads Enriched With Plant Sterols, Either Esterified 4,4-dimethylsterols or Free 4-desmethylsterols, and Plasma Total- and LDL-cholesterol Concentrations." The British Journal of Nutrition, vol. 82, no. 4, 1999, pp. 273-82.
Sierksma A, Weststrate JA, Meijer GW. Spreads enriched with plant sterols, either esterified 4,4-dimethylsterols or free 4-desmethylsterols, and plasma total- and LDL-cholesterol concentrations. Br J Nutr. 1999;82(4):273-82.
Sierksma, A., Weststrate, J. A., & Meijer, G. W. (1999). Spreads enriched with plant sterols, either esterified 4,4-dimethylsterols or free 4-desmethylsterols, and plasma total- and LDL-cholesterol concentrations. The British Journal of Nutrition, 82(4), 273-82.
Sierksma A, Weststrate JA, Meijer GW. Spreads Enriched With Plant Sterols, Either Esterified 4,4-dimethylsterols or Free 4-desmethylsterols, and Plasma Total- and LDL-cholesterol Concentrations. Br J Nutr. 1999;82(4):273-82. PubMed PMID: 10655976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spreads enriched with plant sterols, either esterified 4,4-dimethylsterols or free 4-desmethylsterols, and plasma total- and LDL-cholesterol concentrations. AU - Sierksma,A, AU - Weststrate,J A, AU - Meijer,G W, PY - 2000/2/3/pubmed PY - 2000/2/19/medline PY - 2000/2/3/entrez SP - 273 EP - 82 JF - The British journal of nutrition JO - Br J Nutr VL - 82 IS - 4 N2 - In a 9-week study seventy-six healthy adult volunteers with an average age of 44 (SD 11) years, with baseline plasma total cholesterol levels below 8 mmol/l, received in a balanced, double-blind, crossover design, a total of three different table spreads for personal use. Two spreads were fortified either with free (non-esterified) vegetable-oil sterols, mainly from soyabean oil (31 g sterol equivalents/kg; 0.8 g/d) or sheanut-oil sterols (133 g sterol equivalents/kg; 3.3 g/d). One spread was not fortified (control). Average intake of spread was 25 g/d for 3 weeks. None of the spreads induced changes in blood clinical chemistry or haematology. Plasma total- and LDL-cholesterol concentrations were statistically significantly reduced by 3.8% and 6% (both 0.19 mmol/l) respectively, for the spread enriched with free soyabean-oil sterols compared with the control spread. The spread enriched with sheanut-oil sterols did not lower plasma total- and LDL-cholesterol levels. None of the plant-sterol-enriched spreads affected plasma HDL-cholesterol concentrations. Plasma-lipid-standardized concentrations of alpha- plus beta-carotene were not statistically significantly affected by the soyabean-oil sterol spread in contrast to lipid-standardized plasma lycopene levels which showed a statistically significant decrease (9.5%). These findings indicate that a daily intake of free soyabean-oil sterols as low as 0.8 g added to a spread is effective in lowering blood total- and LDL-cholesterol levels with limited effects on blood carotenoid levels. The lowering in total- and LDL-cholesterol blood levels due to consumption of the vegetable-oil-sterol-enriched spread may be helpful in reducing the risk of CHD for the population. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/10655976/Spreads_enriched_with_plant_sterols_either_esterified_44_dimethylsterols_or_free_4_desmethylsterols_and_plasma_total__and_LDL_cholesterol_concentrations_ L2 - https://www.cambridge.org/core/product/identifier/S0007114599001476/type/journal_article DB - PRIME DP - Unbound Medicine ER -