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Low density lipoprotein cholesterol, lipoprotein(a), and apo(a) isoforms in the elderly: relationship to fasting insulin. Associazione Medica Sabin.
Nutr Metab Cardiovasc Dis. 1999 Oct; 9(5):228-33.NM

Abstract

BACKGROUND AND AIM

Insulin resistance/hyperinsulinemia are often associated with aging and could play an important role in the development of glucose intolerance and dyslipidemia in the elderly. We investigated the relationship between plasma fasting insulin with total cholesterol (TC) and low density lipoprotein LDL cholesterol (LDL-C), triglycerides (TG), lipoprotein(a) [Lp(a)] levels apolipoprotein (a) [apo (a)] isoforms in 100 free-living "healthy" octo-nonagenarians.

METHODS AND RESULTS

Fasting insulin was positively correlated with TG, whereas a negative relation was found with TC and LDL-C (r = -0.29 and r = -0.28 respectively; p < 0.01), LDL-C/apo B, HDL-C and apo A-I levels. Fasting insulin was also inversely correlated with Lp(a) levels (r = -0.22; p < 0.03), whereas the latter were significantly related with TC and LDL-C (r = 0.30 and r = 0.31; p < 0.005), TG (r = 0.21; p < 0.05) and apo B (r = 0.26; p < 0.02). There was a negative relation between Lp(a) levels and apo(a) isoforms: the greater the apo(a) molecular weight, the lower the Lp(a) level (p < 0.0001). Fasting insulin increased with apo(a) size, though the difference in insulin levels among apo(a) isoforms was not significant (p = 0.4). Multiple regression analysis showed that fasting insulin was the best predictor of LDL-C (R2 = 0.14; p = 0.002) irrespective of age, gender, BMI, waist circumference and TG, while apo(a) isoform size, BMI and waist circumference were related with Lp(a) irrespective of TC and LDL-C, TG and apo B (R2 = 0.35 to 0.37; p < 0.0001).

CONCLUSIONS

These results suggest that fasting insulin levels significantly influence LDL-C metabolism in old age. Lp(a) levels seem to be very strongly related to genetic background, although an indirect relation with insulin through adiposity and/or other associated lipid abnormalities cannot be ruled out.

Authors+Show Affiliations

2nd Department of Internal Medicine, University of Ferrara School of Medicine, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10656169

Citation

Carantoni, M, et al. "Low Density Lipoprotein Cholesterol, Lipoprotein(a), and Apo(a) Isoforms in the Elderly: Relationship to Fasting Insulin. Associazione Medica Sabin." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 9, no. 5, 1999, pp. 228-33.
Carantoni M, Zuliani G, Bader G, et al. Low density lipoprotein cholesterol, lipoprotein(a), and apo(a) isoforms in the elderly: relationship to fasting insulin. Associazione Medica Sabin. Nutr Metab Cardiovasc Dis. 1999;9(5):228-33.
Carantoni, M., Zuliani, G., Bader, G., Palmieri, E., Volpato, S., Passaro, A., Imbastaro, T., Mezzetti, A., & Fellin, R. (1999). Low density lipoprotein cholesterol, lipoprotein(a), and apo(a) isoforms in the elderly: relationship to fasting insulin. Associazione Medica Sabin. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 9(5), 228-33.
Carantoni M, et al. Low Density Lipoprotein Cholesterol, Lipoprotein(a), and Apo(a) Isoforms in the Elderly: Relationship to Fasting Insulin. Associazione Medica Sabin. Nutr Metab Cardiovasc Dis. 1999;9(5):228-33. PubMed PMID: 10656169.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low density lipoprotein cholesterol, lipoprotein(a), and apo(a) isoforms in the elderly: relationship to fasting insulin. Associazione Medica Sabin. AU - Carantoni,M, AU - Zuliani,G, AU - Bader,G, AU - Palmieri,E, AU - Volpato,S, AU - Passaro,A, AU - Imbastaro,T, AU - Mezzetti,A, AU - Fellin,R, PY - 2000/2/3/pubmed PY - 2000/2/26/medline PY - 2000/2/3/entrez SP - 228 EP - 33 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 9 IS - 5 N2 - BACKGROUND AND AIM: Insulin resistance/hyperinsulinemia are often associated with aging and could play an important role in the development of glucose intolerance and dyslipidemia in the elderly. We investigated the relationship between plasma fasting insulin with total cholesterol (TC) and low density lipoprotein LDL cholesterol (LDL-C), triglycerides (TG), lipoprotein(a) [Lp(a)] levels apolipoprotein (a) [apo (a)] isoforms in 100 free-living "healthy" octo-nonagenarians. METHODS AND RESULTS: Fasting insulin was positively correlated with TG, whereas a negative relation was found with TC and LDL-C (r = -0.29 and r = -0.28 respectively; p < 0.01), LDL-C/apo B, HDL-C and apo A-I levels. Fasting insulin was also inversely correlated with Lp(a) levels (r = -0.22; p < 0.03), whereas the latter were significantly related with TC and LDL-C (r = 0.30 and r = 0.31; p < 0.005), TG (r = 0.21; p < 0.05) and apo B (r = 0.26; p < 0.02). There was a negative relation between Lp(a) levels and apo(a) isoforms: the greater the apo(a) molecular weight, the lower the Lp(a) level (p < 0.0001). Fasting insulin increased with apo(a) size, though the difference in insulin levels among apo(a) isoforms was not significant (p = 0.4). Multiple regression analysis showed that fasting insulin was the best predictor of LDL-C (R2 = 0.14; p = 0.002) irrespective of age, gender, BMI, waist circumference and TG, while apo(a) isoform size, BMI and waist circumference were related with Lp(a) irrespective of TC and LDL-C, TG and apo B (R2 = 0.35 to 0.37; p < 0.0001). CONCLUSIONS: These results suggest that fasting insulin levels significantly influence LDL-C metabolism in old age. Lp(a) levels seem to be very strongly related to genetic background, although an indirect relation with insulin through adiposity and/or other associated lipid abnormalities cannot be ruled out. SN - 0939-4753 UR - https://www.unboundmedicine.com/medline/citation/10656169/Low_density_lipoprotein_cholesterol_lipoprotein_a__and_apo_a__isoforms_in_the_elderly:_relationship_to_fasting_insulin__Associazione_Medica_Sabin_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -