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The changing epidemiology of diphtheria in the vaccine era.
J Infect Dis. 2000 Feb; 181 Suppl 1:S2-9.JI

Abstract

The epidemic of diphtheria in the Newly Independent States (NIS) of the former Soviet Union has drawn attention to our incomplete understanding of the epidemiology of diphtheria. Many unanswered questions remain concerning the reasons for a resurgence of diphtheria and for the shift in the age of patients and concerning the mechanisms for acquisition of immunity in adults through natural infection under unfavorable living conditions. Other unanswered questions relate to the precise role of socioeconomic factors and hygiene conditions in the initiation, buildup, and spread of the epidemic. Important characteristics of the NIS epidemic can be used to help predict the spread of future diphtheria epidemics. These characteristics include a high proportion of infected adults, a progressive spread of disease from urban centers to rural areas, and transition from initial amplification of disease in groups with high rates of close contacts in focalized, well-distinguished outbreaks to a more generalized epidemic.

Authors+Show Affiliations

National Institute of Hygiene, Warsaw, Poland. sd.internat.immun.consult@t-online.de

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10657184

Citation

Galazka, A. "The Changing Epidemiology of Diphtheria in the Vaccine Era." The Journal of Infectious Diseases, vol. 181 Suppl 1, 2000, pp. S2-9.
Galazka A. The changing epidemiology of diphtheria in the vaccine era. J Infect Dis. 2000;181 Suppl 1:S2-9.
Galazka, A. (2000). The changing epidemiology of diphtheria in the vaccine era. The Journal of Infectious Diseases, 181 Suppl 1, S2-9.
Galazka A. The Changing Epidemiology of Diphtheria in the Vaccine Era. J Infect Dis. 2000;181 Suppl 1:S2-9. PubMed PMID: 10657184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The changing epidemiology of diphtheria in the vaccine era. A1 - Galazka,A, PY - 2000/2/5/pubmed PY - 2000/4/15/medline PY - 2000/2/5/entrez SP - S2 EP - 9 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 181 Suppl 1 N2 - The epidemic of diphtheria in the Newly Independent States (NIS) of the former Soviet Union has drawn attention to our incomplete understanding of the epidemiology of diphtheria. Many unanswered questions remain concerning the reasons for a resurgence of diphtheria and for the shift in the age of patients and concerning the mechanisms for acquisition of immunity in adults through natural infection under unfavorable living conditions. Other unanswered questions relate to the precise role of socioeconomic factors and hygiene conditions in the initiation, buildup, and spread of the epidemic. Important characteristics of the NIS epidemic can be used to help predict the spread of future diphtheria epidemics. These characteristics include a high proportion of infected adults, a progressive spread of disease from urban centers to rural areas, and transition from initial amplification of disease in groups with high rates of close contacts in focalized, well-distinguished outbreaks to a more generalized epidemic. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/10657184/full_citation L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/315533 DB - PRIME DP - Unbound Medicine ER -