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Neurotensin attenuates the quinpirole-induced inhibition of the firing rate of dopamine neurons in the rat substantia nigra pars compacta and the ventral tegmental area.
Neuroscience 2000; 95(2):417-23N

Abstract

In the present study we describe the excitatory effects of the bioactive peptide neurotensin on the electrical activity of dopamine neurons (simultaneously recorded) in the substantia nigra pars compacta and the ventral tegmental area. The neurotensin fragment (8-13) induced comparable increases in firing rate of the substantia nigra and ventral tegmental area dopamine neurons (EC50 values 30 and 45 nM, respectively). The neurotensin receptor antagonist SR142948A antagonized the excitatory effects of neurotensin fragment (8-13) (pA2 values 8.4 and 8.2, respectively). Furthermore, it was found that a low concentration of neurotensin fragment (8-13) (1 nM) attenuated the inhibition of the firing rate by the selective dopamine D2 receptor agonist quinpirole in both neuron types (e.g., the effect of 0.01 microM quinpirole was reduced by approximately 60% in the presence of 1 nM neurotensin fragment [8-13]). Antagonism of this neurotensin fragment (8-13) effect by SR142948A confirms that neurotensin receptors can reduce the effect of dopamine D2 receptors at the single-cell level. These results are discussed in the light of possible roles for neurotensin in neurological disorders such as Parkinson's disease and schizophrenia.

Authors+Show Affiliations

Institute for Neurobiology, University of Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10658621

Citation

Werkman, T R., et al. "Neurotensin Attenuates the Quinpirole-induced Inhibition of the Firing Rate of Dopamine Neurons in the Rat Substantia Nigra Pars Compacta and the Ventral Tegmental Area." Neuroscience, vol. 95, no. 2, 2000, pp. 417-23.
Werkman TR, Kruse CG, Nievelstein H, et al. Neurotensin attenuates the quinpirole-induced inhibition of the firing rate of dopamine neurons in the rat substantia nigra pars compacta and the ventral tegmental area. Neuroscience. 2000;95(2):417-23.
Werkman, T. R., Kruse, C. G., Nievelstein, H., Long, S. K., & Wadman, W. J. (2000). Neurotensin attenuates the quinpirole-induced inhibition of the firing rate of dopamine neurons in the rat substantia nigra pars compacta and the ventral tegmental area. Neuroscience, 95(2), pp. 417-23.
Werkman TR, et al. Neurotensin Attenuates the Quinpirole-induced Inhibition of the Firing Rate of Dopamine Neurons in the Rat Substantia Nigra Pars Compacta and the Ventral Tegmental Area. Neuroscience. 2000;95(2):417-23. PubMed PMID: 10658621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurotensin attenuates the quinpirole-induced inhibition of the firing rate of dopamine neurons in the rat substantia nigra pars compacta and the ventral tegmental area. AU - Werkman,T R, AU - Kruse,C G, AU - Nievelstein,H, AU - Long,S K, AU - Wadman,W J, PY - 2000/2/5/pubmed PY - 2000/3/4/medline PY - 2000/2/5/entrez SP - 417 EP - 23 JF - Neuroscience JO - Neuroscience VL - 95 IS - 2 N2 - In the present study we describe the excitatory effects of the bioactive peptide neurotensin on the electrical activity of dopamine neurons (simultaneously recorded) in the substantia nigra pars compacta and the ventral tegmental area. The neurotensin fragment (8-13) induced comparable increases in firing rate of the substantia nigra and ventral tegmental area dopamine neurons (EC50 values 30 and 45 nM, respectively). The neurotensin receptor antagonist SR142948A antagonized the excitatory effects of neurotensin fragment (8-13) (pA2 values 8.4 and 8.2, respectively). Furthermore, it was found that a low concentration of neurotensin fragment (8-13) (1 nM) attenuated the inhibition of the firing rate by the selective dopamine D2 receptor agonist quinpirole in both neuron types (e.g., the effect of 0.01 microM quinpirole was reduced by approximately 60% in the presence of 1 nM neurotensin fragment [8-13]). Antagonism of this neurotensin fragment (8-13) effect by SR142948A confirms that neurotensin receptors can reduce the effect of dopamine D2 receptors at the single-cell level. These results are discussed in the light of possible roles for neurotensin in neurological disorders such as Parkinson's disease and schizophrenia. SN - 0306-4522 UR - https://www.unboundmedicine.com/medline/citation/10658621/Neurotensin_attenuates_the_quinpirole_induced_inhibition_of_the_firing_rate_of_dopamine_neurons_in_the_rat_substantia_nigra_pars_compacta_and_the_ventral_tegmental_area_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306452299004492 DB - PRIME DP - Unbound Medicine ER -