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Expression of the 5-HT1B receptor by subtypes of rat trigeminal ganglion cells.
Neuroscience. 2000; 95(2):465-71.N

Abstract

The type of trigeminal ganglion cells that express 5-HT1B receptors has not been well characterized, despite the fact that these receptors are important targets for anti-migraine drugs. We have therefore used combined in situ hybridization and immunofluorescence to examine the expression of 5-HT1B receptor messenger RNA in identified subpopulations of rat trigeminal ganglion cells. 5-HT1B-expressing cells accounted for 15% of all trigeminal ganglion cells, were medium sized, and showed immunoreactivity for either 200,000 mol. wt neurofilament, calcitonin gene-related peptide, or nerve growth factor receptor (trkA). In contrast few 5-HT1B cells showed immunoreactivity for substance P or binding of the lectin Griffonia simplicifolia IB4. Our results are consistent with 5-HT1B receptors acting to control the release of calcitonin gene-related peptide from trigeminal neurons with finely myelinated axons. 5-HT1B receptor agonists may reduce neurogenic vasodilation by activating such receptors. However many nociceptive trigeminal neurons, including the substance P and IB4-binding populations, do not express the 5-HT1B receptor.

Authors+Show Affiliations

Division of Biomedical Sciences, St Bartholomew's and Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, UK.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10658626

Citation

Wotherspoon, G, and J V. Priestley. "Expression of the 5-HT1B Receptor By Subtypes of Rat Trigeminal Ganglion Cells." Neuroscience, vol. 95, no. 2, 2000, pp. 465-71.
Wotherspoon G, Priestley JV. Expression of the 5-HT1B receptor by subtypes of rat trigeminal ganglion cells. Neuroscience. 2000;95(2):465-71.
Wotherspoon, G., & Priestley, J. V. (2000). Expression of the 5-HT1B receptor by subtypes of rat trigeminal ganglion cells. Neuroscience, 95(2), 465-71.
Wotherspoon G, Priestley JV. Expression of the 5-HT1B Receptor By Subtypes of Rat Trigeminal Ganglion Cells. Neuroscience. 2000;95(2):465-71. PubMed PMID: 10658626.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Expression of the 5-HT1B receptor by subtypes of rat trigeminal ganglion cells. AU - Wotherspoon,G, AU - Priestley,J V, PY - 2000/2/5/pubmed PY - 2000/3/4/medline PY - 2000/2/5/entrez SP - 465 EP - 71 JF - Neuroscience JO - Neuroscience VL - 95 IS - 2 N2 - The type of trigeminal ganglion cells that express 5-HT1B receptors has not been well characterized, despite the fact that these receptors are important targets for anti-migraine drugs. We have therefore used combined in situ hybridization and immunofluorescence to examine the expression of 5-HT1B receptor messenger RNA in identified subpopulations of rat trigeminal ganglion cells. 5-HT1B-expressing cells accounted for 15% of all trigeminal ganglion cells, were medium sized, and showed immunoreactivity for either 200,000 mol. wt neurofilament, calcitonin gene-related peptide, or nerve growth factor receptor (trkA). In contrast few 5-HT1B cells showed immunoreactivity for substance P or binding of the lectin Griffonia simplicifolia IB4. Our results are consistent with 5-HT1B receptors acting to control the release of calcitonin gene-related peptide from trigeminal neurons with finely myelinated axons. 5-HT1B receptor agonists may reduce neurogenic vasodilation by activating such receptors. However many nociceptive trigeminal neurons, including the substance P and IB4-binding populations, do not express the 5-HT1B receptor. SN - 0306-4522 UR - https://www.unboundmedicine.com/medline/citation/10658626/Expression_of_the_5_HT1B_receptor_by_subtypes_of_rat_trigeminal_ganglion_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306452299004650 DB - PRIME DP - Unbound Medicine ER -