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Vitamin E as an antioxidant/free radical scavenger against amyloid beta-peptide-induced oxidative stress in neocortical synaptosomal membranes and hippocampal neurons in culture: insights into Alzheimer's disease.
Rev Neurosci. 1999; 10(2):141-9.RN

Abstract

Amyloid beta-peptide (Abeta), the major constituent in senile plaques in Alzheimer's disease (AD) brain, is thought by many researchers to be central to neurotoxicity in AD brain. Increasing evidence from many laboratories indicates that AD brain is under oxidative stress, with strong evidence of protein oxidation, lipid peroxidation, and peroxynitrite damage. A link between the central role of Abeta and oxidative stress in AD brain may be Abeta-associated free radical oxidative stress. If so, antioxidants such as vitamin E should modulate Abeta-induced oxidative damage and neurotoxicity in brain cells. This review summarizes studies of Abeta-associated free radical oxidative stress and its inhibition by vitamin E in cortical synaptosomal membranes and hippocampal neuronal cells in culture. Taken together with the recent report that vitamin E slows the progression of AD, this review strongly supports a central role of Abeta-associated free radical oxidative stress in neurotoxicity in AD brain.

Authors+Show Affiliations

Department of Chemistry and Center of Membrane Sciences, University of Kentucky, Lexington 40506-0055, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

10658956

Citation

Butterfield, D A., et al. "Vitamin E as an Antioxidant/free Radical Scavenger Against Amyloid Beta-peptide-induced Oxidative Stress in Neocortical Synaptosomal Membranes and Hippocampal Neurons in Culture: Insights Into Alzheimer's Disease." Reviews in the Neurosciences, vol. 10, no. 2, 1999, pp. 141-9.
Butterfield DA, Koppal T, Subramaniam R, et al. Vitamin E as an antioxidant/free radical scavenger against amyloid beta-peptide-induced oxidative stress in neocortical synaptosomal membranes and hippocampal neurons in culture: insights into Alzheimer's disease. Rev Neurosci. 1999;10(2):141-9.
Butterfield, D. A., Koppal, T., Subramaniam, R., & Yatin, S. (1999). Vitamin E as an antioxidant/free radical scavenger against amyloid beta-peptide-induced oxidative stress in neocortical synaptosomal membranes and hippocampal neurons in culture: insights into Alzheimer's disease. Reviews in the Neurosciences, 10(2), 141-9.
Butterfield DA, et al. Vitamin E as an Antioxidant/free Radical Scavenger Against Amyloid Beta-peptide-induced Oxidative Stress in Neocortical Synaptosomal Membranes and Hippocampal Neurons in Culture: Insights Into Alzheimer's Disease. Rev Neurosci. 1999;10(2):141-9. PubMed PMID: 10658956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin E as an antioxidant/free radical scavenger against amyloid beta-peptide-induced oxidative stress in neocortical synaptosomal membranes and hippocampal neurons in culture: insights into Alzheimer's disease. AU - Butterfield,D A, AU - Koppal,T, AU - Subramaniam,R, AU - Yatin,S, PY - 2000/2/5/pubmed PY - 2000/3/4/medline PY - 2000/2/5/entrez SP - 141 EP - 9 JF - Reviews in the neurosciences JO - Rev Neurosci VL - 10 IS - 2 N2 - Amyloid beta-peptide (Abeta), the major constituent in senile plaques in Alzheimer's disease (AD) brain, is thought by many researchers to be central to neurotoxicity in AD brain. Increasing evidence from many laboratories indicates that AD brain is under oxidative stress, with strong evidence of protein oxidation, lipid peroxidation, and peroxynitrite damage. A link between the central role of Abeta and oxidative stress in AD brain may be Abeta-associated free radical oxidative stress. If so, antioxidants such as vitamin E should modulate Abeta-induced oxidative damage and neurotoxicity in brain cells. This review summarizes studies of Abeta-associated free radical oxidative stress and its inhibition by vitamin E in cortical synaptosomal membranes and hippocampal neuronal cells in culture. Taken together with the recent report that vitamin E slows the progression of AD, this review strongly supports a central role of Abeta-associated free radical oxidative stress in neurotoxicity in AD brain. SN - 0334-1763 UR - https://www.unboundmedicine.com/medline/citation/10658956/Vitamin_E_as_an_antioxidant/free_radical_scavenger_against_amyloid_beta_peptide_induced_oxidative_stress_in_neocortical_synaptosomal_membranes_and_hippocampal_neurons_in_culture:_insights_into_Alzheimer's_disease_ DB - PRIME DP - Unbound Medicine ER -