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The electroencephalogram in dementia with Lewy bodies.
Acta Neurol Scand. 2000 Jan; 101(1):53-6.AN

Abstract

OBJECTIVES

Dementia with Lewy bodies (DLB) is the second commonest neurodegenerative cause of dementia. While there is consensus on the clinical diagnostic criteria for DLB, the use of EEG to increase the diagnostic sensitivity has not been substantiated.

MATERIAL AND METHODS

We studied the resting EEG findings in 18 consecutive patients with DLB and compared them with a control group of 20 patients with "probable" Alzheimer's disease (AD). We aimed to evaluate the use of EEG in a representative sample of patients with DLB.

RESULTS

All patients with DLB fulfilled accepted clinical criteria for DLB. The DLB group had a more severe dementia than the AD group, as measured by the Mini-Mental State Examination (MMSE) test (DLB mean MMSE 9.4 and AD mean MMSE 17.2) despite a similar duration of overall severity of illness. The EEG was slow in both groups, predominantly in the 4-7 Hz range. Although there was no statistically significant difference in the EEG findings between the DLB and AD groups, there was a correlation between the EEG score and MMSE score (Spearman Rank correlation rs = -0.61, P < 0.001).

CONCLUSION

These findings suggest that although patients with DLB have a more aggressive course than AD, EEG abnormalities do not differ in the 2 groups. However, we believe the EEG provides important supporting diagnostic information in DLB.

Authors+Show Affiliations

Cerebral Function Unit, Manchester Royal Infirmary, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10660153

Citation

Barber, P A., et al. "The Electroencephalogram in Dementia With Lewy Bodies." Acta Neurologica Scandinavica, vol. 101, no. 1, 2000, pp. 53-6.
Barber PA, Varma AR, Lloyd JJ, et al. The electroencephalogram in dementia with Lewy bodies. Acta Neurol Scand. 2000;101(1):53-6.
Barber, P. A., Varma, A. R., Lloyd, J. J., Haworth, B., Snowden, J. S., & Neary, D. (2000). The electroencephalogram in dementia with Lewy bodies. Acta Neurologica Scandinavica, 101(1), 53-6.
Barber PA, et al. The Electroencephalogram in Dementia With Lewy Bodies. Acta Neurol Scand. 2000;101(1):53-6. PubMed PMID: 10660153.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The electroencephalogram in dementia with Lewy bodies. AU - Barber,P A, AU - Varma,A R, AU - Lloyd,J J, AU - Haworth,B, AU - Snowden,J S, AU - Neary,D, PY - 2000/2/5/pubmed PY - 2000/3/4/medline PY - 2000/2/5/entrez SP - 53 EP - 6 JF - Acta neurologica Scandinavica JO - Acta Neurol Scand VL - 101 IS - 1 N2 - OBJECTIVES: Dementia with Lewy bodies (DLB) is the second commonest neurodegenerative cause of dementia. While there is consensus on the clinical diagnostic criteria for DLB, the use of EEG to increase the diagnostic sensitivity has not been substantiated. MATERIAL AND METHODS: We studied the resting EEG findings in 18 consecutive patients with DLB and compared them with a control group of 20 patients with "probable" Alzheimer's disease (AD). We aimed to evaluate the use of EEG in a representative sample of patients with DLB. RESULTS: All patients with DLB fulfilled accepted clinical criteria for DLB. The DLB group had a more severe dementia than the AD group, as measured by the Mini-Mental State Examination (MMSE) test (DLB mean MMSE 9.4 and AD mean MMSE 17.2) despite a similar duration of overall severity of illness. The EEG was slow in both groups, predominantly in the 4-7 Hz range. Although there was no statistically significant difference in the EEG findings between the DLB and AD groups, there was a correlation between the EEG score and MMSE score (Spearman Rank correlation rs = -0.61, P < 0.001). CONCLUSION: These findings suggest that although patients with DLB have a more aggressive course than AD, EEG abnormalities do not differ in the 2 groups. However, we believe the EEG provides important supporting diagnostic information in DLB. SN - 0001-6314 UR - https://www.unboundmedicine.com/medline/citation/10660153/The_electroencephalogram_in_dementia_with_Lewy_bodies_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0001-6314&amp;date=2000&amp;volume=101&amp;issue=1&amp;spage=53 DB - PRIME DP - Unbound Medicine ER -