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The effect of low-level blood lead on hematologic parameters in children.
Environ Res. 2000 Feb; 82(2):150-9.ER

Abstract

A health survey of school children living in polluted regions of eastern Germany provided us with data necessary to examine the effects of lead on the blood system at levels below current standards for blood lead content. Data collected for 797 children, aged 5-14 years, with low blood lead levels (GM, 33.3 microg Pb/L; range, 7.5-239 microg Pb/L) allowed us to examine the relationship between blood lead content and hematological parameters. Using linear regression analyses and controlling for a number of potential confounding factors, we found that increasing blood lead levels by 10 microg/L were associated with a small increase in the number of red blood cells and in girls with reduced MCV and MCH. The reasons for our observation, especially the gender difference, are still uncertain. In conclusion the morphology and function of erythrocytes might be sensitive parameters of low dose lead toxicity.

Authors+Show Affiliations

GSF-Forschungszentrum für Umwelt und Gesundheit, Institut für Epidemiologie, Ingolstädter Landstrasse 1, Neuherberg, D-85758, Germany. beate.jacob@gsf.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10662529

Citation

Jacob, B, et al. "The Effect of Low-level Blood Lead On Hematologic Parameters in Children." Environmental Research, vol. 82, no. 2, 2000, pp. 150-9.
Jacob B, Ritz B, Heinrich J, et al. The effect of low-level blood lead on hematologic parameters in children. Environ Res. 2000;82(2):150-9.
Jacob, B., Ritz, B., Heinrich, J., Hoelscher, B., & Wichmann, H. E. (2000). The effect of low-level blood lead on hematologic parameters in children. Environmental Research, 82(2), 150-9.
Jacob B, et al. The Effect of Low-level Blood Lead On Hematologic Parameters in Children. Environ Res. 2000;82(2):150-9. PubMed PMID: 10662529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of low-level blood lead on hematologic parameters in children. AU - Jacob,B, AU - Ritz,B, AU - Heinrich,J, AU - Hoelscher,B, AU - Wichmann,H E, PY - 2000/2/9/pubmed PY - 2000/3/18/medline PY - 2000/2/9/entrez SP - 150 EP - 9 JF - Environmental research JO - Environ Res VL - 82 IS - 2 N2 - A health survey of school children living in polluted regions of eastern Germany provided us with data necessary to examine the effects of lead on the blood system at levels below current standards for blood lead content. Data collected for 797 children, aged 5-14 years, with low blood lead levels (GM, 33.3 microg Pb/L; range, 7.5-239 microg Pb/L) allowed us to examine the relationship between blood lead content and hematological parameters. Using linear regression analyses and controlling for a number of potential confounding factors, we found that increasing blood lead levels by 10 microg/L were associated with a small increase in the number of red blood cells and in girls with reduced MCV and MCH. The reasons for our observation, especially the gender difference, are still uncertain. In conclusion the morphology and function of erythrocytes might be sensitive parameters of low dose lead toxicity. SN - 0013-9351 UR - https://www.unboundmedicine.com/medline/citation/10662529/The_effect_of_low_level_blood_lead_on_hematologic_parameters_in_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(99)94011-2 DB - PRIME DP - Unbound Medicine ER -