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The effect of bupropion on nicotine craving and withdrawal.
Psychopharmacology (Berl) 2000; 148(1):33-40P

Abstract

RATIONALE AND OBJECTIVES

Bupropion has demonstrated efficacy for smoking cessation. Given the importance of nicotine craving and withdrawal in the smoking cessation process, the current study examined the effects of bupropion on these parameters during smoking abstinence.

METHODS

During a 2-day Baseline phase with ad lib smoking, 91 non-depressed smokers (who were not trying to quit permanently) were administered measures of nicotine craving, withdrawal symptoms, and timed measures of cognitive performance five times daily. Participants were then assigned randomly to a 14-day treatment regimen with bupropion 300 mg/day, bupropion 150 mg/day, or placebo. Thereafter, the above measures were re-administered during 3 days of abstinence on a closed research ward.

RESULTS

Relative to placebo, 300 mg bupropion significantly reduced abstinence-associated increases in rated depression, difficulty concentrating, and irritability, and attenuated a decrease in positive affect. The results also suggested that bupropion might have a positive effect on performance measures during the withdrawal period. No effects were observed on craving, anxiety, restlessness, or hunger. The lack of findings on craving measures may be explained by a floor effect; except on the first day of abstinence, neither drug nor placebo groups showed much craving elevation during abstinence.

CONCLUSIONS

Study results indicate that bupropion ameliorates some nicotine withdrawal symptoms.

Authors+Show Affiliations

Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA. shiffman@pinneyassociates.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10663415

Citation

Shiffman, S, et al. "The Effect of Bupropion On Nicotine Craving and Withdrawal." Psychopharmacology, vol. 148, no. 1, 2000, pp. 33-40.
Shiffman S, Johnston JA, Khayrallah M, et al. The effect of bupropion on nicotine craving and withdrawal. Psychopharmacology (Berl). 2000;148(1):33-40.
Shiffman, S., Johnston, J. A., Khayrallah, M., Elash, C. A., Gwaltney, C. J., Paty, J. A., ... DeVeaugh-Geiss, J. (2000). The effect of bupropion on nicotine craving and withdrawal. Psychopharmacology, 148(1), pp. 33-40.
Shiffman S, et al. The Effect of Bupropion On Nicotine Craving and Withdrawal. Psychopharmacology (Berl). 2000;148(1):33-40. PubMed PMID: 10663415.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of bupropion on nicotine craving and withdrawal. AU - Shiffman,S, AU - Johnston,J A, AU - Khayrallah,M, AU - Elash,C A, AU - Gwaltney,C J, AU - Paty,J A, AU - Gnys,M, AU - Evoniuk,G, AU - DeVeaugh-Geiss,J, PY - 2000/2/9/pubmed PY - 2000/3/4/medline PY - 2000/2/9/entrez SP - 33 EP - 40 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 148 IS - 1 N2 - RATIONALE AND OBJECTIVES: Bupropion has demonstrated efficacy for smoking cessation. Given the importance of nicotine craving and withdrawal in the smoking cessation process, the current study examined the effects of bupropion on these parameters during smoking abstinence. METHODS: During a 2-day Baseline phase with ad lib smoking, 91 non-depressed smokers (who were not trying to quit permanently) were administered measures of nicotine craving, withdrawal symptoms, and timed measures of cognitive performance five times daily. Participants were then assigned randomly to a 14-day treatment regimen with bupropion 300 mg/day, bupropion 150 mg/day, or placebo. Thereafter, the above measures were re-administered during 3 days of abstinence on a closed research ward. RESULTS: Relative to placebo, 300 mg bupropion significantly reduced abstinence-associated increases in rated depression, difficulty concentrating, and irritability, and attenuated a decrease in positive affect. The results also suggested that bupropion might have a positive effect on performance measures during the withdrawal period. No effects were observed on craving, anxiety, restlessness, or hunger. The lack of findings on craving measures may be explained by a floor effect; except on the first day of abstinence, neither drug nor placebo groups showed much craving elevation during abstinence. CONCLUSIONS: Study results indicate that bupropion ameliorates some nicotine withdrawal symptoms. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/10663415/The_effect_of_bupropion_on_nicotine_craving_and_withdrawal_ L2 - https://dx.doi.org/10.1007/s002130050022 DB - PRIME DP - Unbound Medicine ER -