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Benign metastasizing leiomyoma: a cytogenetically balanced but clonal disease.
Hum Pathol. 2000 Jan; 31(1):126-8.HP

Abstract

Benign metastasizing leiomyoma (BML) is a rare condition, characterized by the occurrence of multiple smooth-muscle nodules, most often located in the lung after previous hysterectomy because of histologically benign appearing leiomyoma. Although the condition resembles a metastatic process, case studies provided evidence that it may be the result of an intravenous leiomyomatosis or an independent and multifocal smooth-muscle proliferation. Comparative genomic hybridization and X-chromosome inactivation analysis were used in a case of BML to determine whether pulmonary and uterine tumors are related one to another. A balanced karyotype, previously reported in leiomyomas and an identical X-chromosome inactivation pattern found in all tumorlets, is most consistent with a monoclonal origin of both uterine and pulmonary tumors and the interpretation that pulmonary lesions are metastatic.

Authors+Show Affiliations

Institute of Pathology and Department of Internal Medicine, Aachen University of Technology, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

10665925

Citation

Tietze, L, et al. "Benign Metastasizing Leiomyoma: a Cytogenetically Balanced but Clonal Disease." Human Pathology, vol. 31, no. 1, 2000, pp. 126-8.
Tietze L, Günther K, Hörbe A, et al. Benign metastasizing leiomyoma: a cytogenetically balanced but clonal disease. Hum Pathol. 2000;31(1):126-8.
Tietze, L., Günther, K., Hörbe, A., Pawlik, C., Klosterhalfen, B., Handt, S., & Merkelbach-Bruse, S. (2000). Benign metastasizing leiomyoma: a cytogenetically balanced but clonal disease. Human Pathology, 31(1), 126-8.
Tietze L, et al. Benign Metastasizing Leiomyoma: a Cytogenetically Balanced but Clonal Disease. Hum Pathol. 2000;31(1):126-8. PubMed PMID: 10665925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Benign metastasizing leiomyoma: a cytogenetically balanced but clonal disease. AU - Tietze,L, AU - Günther,K, AU - Hörbe,A, AU - Pawlik,C, AU - Klosterhalfen,B, AU - Handt,S, AU - Merkelbach-Bruse,S, PY - 2000/2/9/pubmed PY - 2000/2/19/medline PY - 2000/2/9/entrez SP - 126 EP - 8 JF - Human pathology JO - Hum. Pathol. VL - 31 IS - 1 N2 - Benign metastasizing leiomyoma (BML) is a rare condition, characterized by the occurrence of multiple smooth-muscle nodules, most often located in the lung after previous hysterectomy because of histologically benign appearing leiomyoma. Although the condition resembles a metastatic process, case studies provided evidence that it may be the result of an intravenous leiomyomatosis or an independent and multifocal smooth-muscle proliferation. Comparative genomic hybridization and X-chromosome inactivation analysis were used in a case of BML to determine whether pulmonary and uterine tumors are related one to another. A balanced karyotype, previously reported in leiomyomas and an identical X-chromosome inactivation pattern found in all tumorlets, is most consistent with a monoclonal origin of both uterine and pulmonary tumors and the interpretation that pulmonary lesions are metastatic. SN - 0046-8177 UR - https://www.unboundmedicine.com/medline/citation/10665925/Benign_metastasizing_leiomyoma:_a_cytogenetically_balanced_but_clonal_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0046-8177(00)80210-5 DB - PRIME DP - Unbound Medicine ER -