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RANTES production by T cells and CD8-mediated inhibition of human immunodeficiency virus gene expression before initiation of potent antiretroviral therapy predict sustained suppression of viral replication.
J Infect Dis 2000; 181(2):505-12JI

Abstract

A prospective blinded study was conducted to determine whether immunological differences exist between patients receiving potent antiretroviral therapy who are able to achieve and maintain an undetectable virus load (<50 copies/mL) and those who are not. Eleven patients receiving protease inhibitor-containing antiretroviral therapy were studied for 1 year. After analysis of all baseline samples, patient virus load was disclosed, and patients were classified as suppressors (those who maintained undetectable virus load for 1 year) and nonsuppressors. Baseline virus load and CD4+ T cell count did not differ significantly between the 2 groups. Levels of RANTES production by CD4+ and CD8+ T cells and CD8-mediated inhibition of human immunodeficiency virus type 1 gene expression before initiation of antiretroviral therapy were significantly associated with an undetectable virus load maintained for 1 year (P<.05). Thus, a functionally intact T cell-mediated immune system at the time of initiation of potent antiretroviral therapy may predict long-term virus suppression.

Authors+Show Affiliations

Department of Pathology, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

10669333

Citation

Fransen, S, et al. "RANTES Production By T Cells and CD8-mediated Inhibition of Human Immunodeficiency Virus Gene Expression Before Initiation of Potent Antiretroviral Therapy Predict Sustained Suppression of Viral Replication." The Journal of Infectious Diseases, vol. 181, no. 2, 2000, pp. 505-12.
Fransen S, Copeland KF, Smieja M, et al. RANTES production by T cells and CD8-mediated inhibition of human immunodeficiency virus gene expression before initiation of potent antiretroviral therapy predict sustained suppression of viral replication. J Infect Dis. 2000;181(2):505-12.
Fransen, S., Copeland, K. F., Smieja, M., Smaill, F., & Rosenthal, K. L. (2000). RANTES production by T cells and CD8-mediated inhibition of human immunodeficiency virus gene expression before initiation of potent antiretroviral therapy predict sustained suppression of viral replication. The Journal of Infectious Diseases, 181(2), pp. 505-12.
Fransen S, et al. RANTES Production By T Cells and CD8-mediated Inhibition of Human Immunodeficiency Virus Gene Expression Before Initiation of Potent Antiretroviral Therapy Predict Sustained Suppression of Viral Replication. J Infect Dis. 2000;181(2):505-12. PubMed PMID: 10669333.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - RANTES production by T cells and CD8-mediated inhibition of human immunodeficiency virus gene expression before initiation of potent antiretroviral therapy predict sustained suppression of viral replication. AU - Fransen,S, AU - Copeland,K F, AU - Smieja,M, AU - Smaill,F, AU - Rosenthal,K L, PY - 2000/2/11/pubmed PY - 2000/4/15/medline PY - 2000/2/11/entrez SP - 505 EP - 12 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 181 IS - 2 N2 - A prospective blinded study was conducted to determine whether immunological differences exist between patients receiving potent antiretroviral therapy who are able to achieve and maintain an undetectable virus load (<50 copies/mL) and those who are not. Eleven patients receiving protease inhibitor-containing antiretroviral therapy were studied for 1 year. After analysis of all baseline samples, patient virus load was disclosed, and patients were classified as suppressors (those who maintained undetectable virus load for 1 year) and nonsuppressors. Baseline virus load and CD4+ T cell count did not differ significantly between the 2 groups. Levels of RANTES production by CD4+ and CD8+ T cells and CD8-mediated inhibition of human immunodeficiency virus type 1 gene expression before initiation of antiretroviral therapy were significantly associated with an undetectable virus load maintained for 1 year (P<.05). Thus, a functionally intact T cell-mediated immune system at the time of initiation of potent antiretroviral therapy may predict long-term virus suppression. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/10669333/RANTES_production_by_T_cells_and_CD8_mediated_inhibition_of_human_immunodeficiency_virus_gene_expression_before_initiation_of_potent_antiretroviral_therapy_predict_sustained_suppression_of_viral_replication_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/315270 DB - PRIME DP - Unbound Medicine ER -