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Effect of influenza vaccination on viral replication and immune response in persons infected with human immunodeficiency virus receiving potent antiretroviral therapy.
J Infect Dis 2000; 181(2):522-31JI

Abstract

Nineteen patients infected with human immunodeficiency virus (HIV) with varying levels of viral suppression achieved with antiretroviral therapy were evaluated to determine whether trivalent influenza vaccine activated HIV replication. Humoral immune responses and CD4+ lymphocyte subsets were compared in 5 HIV-uninfected vaccinated subjects. Transient elevations of plasma HIV RNA levels (76-89 copies/mL) appeared within 2 weeks in 3 of 11 patients with <50 copies/mL at baseline. Sustained elevation in HIV plasma RNA was observed in 7 of 8 patients with baseline HIV RNA of >50 copies/mL. HIV DNA decreased in patients with <400 RNA copies/mL at baseline and showed an HIV RNA increase after vaccination (n=8) when compared with 8 patients with <50 copies/mL at baseline who lacked viral response to vaccination. Concurrent decreases in proviral DNA and memory phenotype CD4+ cells in association with increased plasma HIV RNA after vaccination in patients with <400 RNA copies/mL at baseline suggest that in vivo mobilization of the latently infected cell reservoir may occur during potent antiretroviral therapy.

Authors+Show Affiliations

Department of Pathology, University of California San Diego, School of Medicine, La Jolla, California, USA. huldrych.guenthard@dim.usz.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10669335

Citation

Günthard, H F., et al. "Effect of Influenza Vaccination On Viral Replication and Immune Response in Persons Infected With Human Immunodeficiency Virus Receiving Potent Antiretroviral Therapy." The Journal of Infectious Diseases, vol. 181, no. 2, 2000, pp. 522-31.
Günthard HF, Wong JK, Spina CA, et al. Effect of influenza vaccination on viral replication and immune response in persons infected with human immunodeficiency virus receiving potent antiretroviral therapy. J Infect Dis. 2000;181(2):522-31.
Günthard, H. F., Wong, J. K., Spina, C. A., Ignacio, C., Kwok, S., Christopherson, C., ... Richman, D. D. (2000). Effect of influenza vaccination on viral replication and immune response in persons infected with human immunodeficiency virus receiving potent antiretroviral therapy. The Journal of Infectious Diseases, 181(2), pp. 522-31.
Günthard HF, et al. Effect of Influenza Vaccination On Viral Replication and Immune Response in Persons Infected With Human Immunodeficiency Virus Receiving Potent Antiretroviral Therapy. J Infect Dis. 2000;181(2):522-31. PubMed PMID: 10669335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of influenza vaccination on viral replication and immune response in persons infected with human immunodeficiency virus receiving potent antiretroviral therapy. AU - Günthard,H F, AU - Wong,J K, AU - Spina,C A, AU - Ignacio,C, AU - Kwok,S, AU - Christopherson,C, AU - Hwang,J, AU - Haubrich,R, AU - Havlir,D, AU - Richman,D D, PY - 2000/2/11/pubmed PY - 2000/4/15/medline PY - 2000/2/11/entrez SP - 522 EP - 31 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 181 IS - 2 N2 - Nineteen patients infected with human immunodeficiency virus (HIV) with varying levels of viral suppression achieved with antiretroviral therapy were evaluated to determine whether trivalent influenza vaccine activated HIV replication. Humoral immune responses and CD4+ lymphocyte subsets were compared in 5 HIV-uninfected vaccinated subjects. Transient elevations of plasma HIV RNA levels (76-89 copies/mL) appeared within 2 weeks in 3 of 11 patients with <50 copies/mL at baseline. Sustained elevation in HIV plasma RNA was observed in 7 of 8 patients with baseline HIV RNA of >50 copies/mL. HIV DNA decreased in patients with <400 RNA copies/mL at baseline and showed an HIV RNA increase after vaccination (n=8) when compared with 8 patients with <50 copies/mL at baseline who lacked viral response to vaccination. Concurrent decreases in proviral DNA and memory phenotype CD4+ cells in association with increased plasma HIV RNA after vaccination in patients with <400 RNA copies/mL at baseline suggest that in vivo mobilization of the latently infected cell reservoir may occur during potent antiretroviral therapy. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/10669335/Effect_of_influenza_vaccination_on_viral_replication_and_immune_response_in_persons_infected_with_human_immunodeficiency_virus_receiving_potent_antiretroviral_therapy_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/315260 DB - PRIME DP - Unbound Medicine ER -