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Role of Streptococcus pneumoniae and Haemophilus influenzae in the development of acute otitis media and otitis media with effusion in a gerbil model.
J Infect Dis. 2000 Feb; 181(2):646-52.JI

Abstract

The efficacy of amoxicillin/clavulanate and cefuroxime was determined in a gerbil model of otitis media with a mixed Streptococcus pneumoniae plus Haemophilus influenzae middle ear (ME) infection. Results were compared with those obtained in a previous single H. influenzae model. All untreated animals inoculated with the mixed inoculum developed acute otitis media (AOM), whereas 86.7% of those inoculated with H. influenzae developed otitis media with effusion (OME). Antibiotics eradicated H. influenzae from the ME more efficiently in AOM than in OME, and this difference was highly significant (P</=.001) after administration of 5 mg/kg of either drug (amoxicillin/clavulanate, 100% vs. 10%; cefuroxime, 73.3% vs. 10%). Efficacy was predicted by the relation of in vitro susceptibility and ME antibiotic concentration, which was 2.7 times higher in AOM than in OME. In the mixed otitis model, the most efficacious antibiotic was able to prevent AOM, but >80% of animals developed culture-negative OME.

Authors+Show Affiliations

Department of Medical Microbiology, Fundación Jiménez Díaz, 28040 Madrid, Spain. fsoriano@microb.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10669350

Citation

Soriano, F, et al. "Role of Streptococcus Pneumoniae and Haemophilus Influenzae in the Development of Acute Otitis Media and Otitis Media With Effusion in a Gerbil Model." The Journal of Infectious Diseases, vol. 181, no. 2, 2000, pp. 646-52.
Soriano F, Parra A, Cenjor C, et al. Role of Streptococcus pneumoniae and Haemophilus influenzae in the development of acute otitis media and otitis media with effusion in a gerbil model. J Infect Dis. 2000;181(2):646-52.
Soriano, F., Parra, A., Cenjor, C., Nieto, E., García-Calvo, G., Giménez, M. J., Aguilar, L., & Ponte, C. (2000). Role of Streptococcus pneumoniae and Haemophilus influenzae in the development of acute otitis media and otitis media with effusion in a gerbil model. The Journal of Infectious Diseases, 181(2), 646-52.
Soriano F, et al. Role of Streptococcus Pneumoniae and Haemophilus Influenzae in the Development of Acute Otitis Media and Otitis Media With Effusion in a Gerbil Model. J Infect Dis. 2000;181(2):646-52. PubMed PMID: 10669350.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of Streptococcus pneumoniae and Haemophilus influenzae in the development of acute otitis media and otitis media with effusion in a gerbil model. AU - Soriano,F, AU - Parra,A, AU - Cenjor,C, AU - Nieto,E, AU - García-Calvo,G, AU - Giménez,M J, AU - Aguilar,L, AU - Ponte,C, PY - 2000/2/11/pubmed PY - 2000/4/15/medline PY - 2000/2/11/entrez SP - 646 EP - 52 JF - The Journal of infectious diseases JO - J Infect Dis VL - 181 IS - 2 N2 - The efficacy of amoxicillin/clavulanate and cefuroxime was determined in a gerbil model of otitis media with a mixed Streptococcus pneumoniae plus Haemophilus influenzae middle ear (ME) infection. Results were compared with those obtained in a previous single H. influenzae model. All untreated animals inoculated with the mixed inoculum developed acute otitis media (AOM), whereas 86.7% of those inoculated with H. influenzae developed otitis media with effusion (OME). Antibiotics eradicated H. influenzae from the ME more efficiently in AOM than in OME, and this difference was highly significant (P</=.001) after administration of 5 mg/kg of either drug (amoxicillin/clavulanate, 100% vs. 10%; cefuroxime, 73.3% vs. 10%). Efficacy was predicted by the relation of in vitro susceptibility and ME antibiotic concentration, which was 2.7 times higher in AOM than in OME. In the mixed otitis model, the most efficacious antibiotic was able to prevent AOM, but >80% of animals developed culture-negative OME. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/10669350/Role_of_Streptococcus_pneumoniae_and_Haemophilus_influenzae_in_the_development_of_acute_otitis_media_and_otitis_media_with_effusion_in_a_gerbil_model_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/315237 DB - PRIME DP - Unbound Medicine ER -