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Recombinant human interleukin-11 has anti-inflammatory actions yet does not exacerbate systemic Listeria infection.
J Infect Dis. 2000 Feb; 181(2):754-6.JI

Abstract

To determine whether recombinant human (rh) interleukin (IL)-11 disrupts the clearance of microbial pathogens, mice were challenged with Listeria monocytogenes after receiving high-dose rhIL-11, anti-tumor necrosis factor (TNF) monoclonal antibody (MAb), anti-IL-11 MAb, or saline control. The LD50 was not affected by rhIL-11 but was 10-fold lower in the anti-TNF MAb group (P<.001). Plasma IL-6, IL-1beta, and TNF-alpha levels were not different between rhIL-11-treated animals and the control group; however, interferon-gamma levels were significantly reduced by IL-11 treatment (2477 vs. 0 pg/mL, P<.01). Compared with the control group, the quantitative level of L. monocytogenes in hepatic and splenic tissue was unchanged by rhIL-11 but was significantly increased by TNF or IL-11 inhibition. The results indicate that IL-11 down-regulates cytokine production but does not exacerbate systemic infection in the murine Listeria infection model.

Authors+Show Affiliations

Division of Infectious Diseases, Brown University School of Medicine, Memorial Hospital of Rhode Island, Pawtucket, RI 02860, USA. Steven_Opal@brown.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10669370

Citation

Opal, S M., et al. "Recombinant Human Interleukin-11 Has Anti-inflammatory Actions yet Does Not Exacerbate Systemic Listeria Infection." The Journal of Infectious Diseases, vol. 181, no. 2, 2000, pp. 754-6.
Opal SM, Keith JC, Palardy JE, et al. Recombinant human interleukin-11 has anti-inflammatory actions yet does not exacerbate systemic Listeria infection. J Infect Dis. 2000;181(2):754-6.
Opal, S. M., Keith, J. C., Palardy, J. E., & Parejo, N. (2000). Recombinant human interleukin-11 has anti-inflammatory actions yet does not exacerbate systemic Listeria infection. The Journal of Infectious Diseases, 181(2), 754-6.
Opal SM, et al. Recombinant Human Interleukin-11 Has Anti-inflammatory Actions yet Does Not Exacerbate Systemic Listeria Infection. J Infect Dis. 2000;181(2):754-6. PubMed PMID: 10669370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recombinant human interleukin-11 has anti-inflammatory actions yet does not exacerbate systemic Listeria infection. AU - Opal,S M, AU - Keith,J C, AU - Palardy,J E, AU - Parejo,N, PY - 2000/2/11/pubmed PY - 2000/4/15/medline PY - 2000/2/11/entrez SP - 754 EP - 6 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 181 IS - 2 N2 - To determine whether recombinant human (rh) interleukin (IL)-11 disrupts the clearance of microbial pathogens, mice were challenged with Listeria monocytogenes after receiving high-dose rhIL-11, anti-tumor necrosis factor (TNF) monoclonal antibody (MAb), anti-IL-11 MAb, or saline control. The LD50 was not affected by rhIL-11 but was 10-fold lower in the anti-TNF MAb group (P<.001). Plasma IL-6, IL-1beta, and TNF-alpha levels were not different between rhIL-11-treated animals and the control group; however, interferon-gamma levels were significantly reduced by IL-11 treatment (2477 vs. 0 pg/mL, P<.01). Compared with the control group, the quantitative level of L. monocytogenes in hepatic and splenic tissue was unchanged by rhIL-11 but was significantly increased by TNF or IL-11 inhibition. The results indicate that IL-11 down-regulates cytokine production but does not exacerbate systemic infection in the murine Listeria infection model. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/10669370/Recombinant_human_interleukin_11_has_anti_inflammatory_actions_yet_does_not_exacerbate_systemic_Listeria_infection_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/315247 DB - PRIME DP - Unbound Medicine ER -