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Residual low-level viral replication could explain discrepancies between viral load and CD4+ cell response in human immunodeficiency virus-infected patients receiving antiretroviral therapy.
Clin Infect Dis 2000; 30(2):392-4CI

Abstract

We report the evolution of chronic infection with human immunodeficiency virus type 1 (HIV-1) in a patient treated with stavudine plus didanosine, whose CD4+ lymphocyte count progressively decreased, despite a sustained plasma viral load <20 copies/mL. After 12 months of therapy, treatment was switched to zidovudine plus lamivudine plus nelfinavir. CD4+ T cell count decreased from 559 x 10(6)/L at month 0 to 259 x 10(6)/L at month 12. Plasma viral load decreased from 21,665 HIV-1 RNA copies/mL at baseline (month 0) to <20 copies/mL after 1 month of therapy with stavudine plus didanosine, and remained below 20 copies/mL until month 12, but always >5 copies/mL. Viral load in tonsilar tissue at month 12 was 125,000 copies/mg of tissue. After the change to triple-drug therapy, the plasma viral load decreased to 5 copies/mL, the CD4+ T cell count increased to 705 x 10(6)/L, and the viral load in tonsilar tissue decreased to <40 copies/mg of tissue at month 24. A low level of HIV-1 replication could explain the lack of immunologic response in patients with apparent virological response.

Authors+Show Affiliations

Infectious Diseases Unit, Hospital Clínic, Faculty of Medicine, University of Barcelona, Barcelona, Spain. fgarcia@medicina.ub.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10671348

Citation

García, F, et al. "Residual Low-level Viral Replication Could Explain Discrepancies Between Viral Load and CD4+ Cell Response in Human Immunodeficiency Virus-infected Patients Receiving Antiretroviral Therapy." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 30, no. 2, 2000, pp. 392-4.
García F, Vidal C, Plana M, et al. Residual low-level viral replication could explain discrepancies between viral load and CD4+ cell response in human immunodeficiency virus-infected patients receiving antiretroviral therapy. Clin Infect Dis. 2000;30(2):392-4.
García, F., Vidal, C., Plana, M., Cruceta, A., Gallart, M. T., Pumarola, T., ... Gatell, J. M. (2000). Residual low-level viral replication could explain discrepancies between viral load and CD4+ cell response in human immunodeficiency virus-infected patients receiving antiretroviral therapy. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 30(2), pp. 392-4.
García F, et al. Residual Low-level Viral Replication Could Explain Discrepancies Between Viral Load and CD4+ Cell Response in Human Immunodeficiency Virus-infected Patients Receiving Antiretroviral Therapy. Clin Infect Dis. 2000;30(2):392-4. PubMed PMID: 10671348.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Residual low-level viral replication could explain discrepancies between viral load and CD4+ cell response in human immunodeficiency virus-infected patients receiving antiretroviral therapy. AU - García,F, AU - Vidal,C, AU - Plana,M, AU - Cruceta,A, AU - Gallart,M T, AU - Pumarola,T, AU - Miro,J M, AU - Gatell,J M, PY - 2000/2/15/pubmed PY - 2000/4/15/medline PY - 2000/2/15/entrez SP - 392 EP - 4 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 30 IS - 2 N2 - We report the evolution of chronic infection with human immunodeficiency virus type 1 (HIV-1) in a patient treated with stavudine plus didanosine, whose CD4+ lymphocyte count progressively decreased, despite a sustained plasma viral load <20 copies/mL. After 12 months of therapy, treatment was switched to zidovudine plus lamivudine plus nelfinavir. CD4+ T cell count decreased from 559 x 10(6)/L at month 0 to 259 x 10(6)/L at month 12. Plasma viral load decreased from 21,665 HIV-1 RNA copies/mL at baseline (month 0) to <20 copies/mL after 1 month of therapy with stavudine plus didanosine, and remained below 20 copies/mL until month 12, but always >5 copies/mL. Viral load in tonsilar tissue at month 12 was 125,000 copies/mg of tissue. After the change to triple-drug therapy, the plasma viral load decreased to 5 copies/mL, the CD4+ T cell count increased to 705 x 10(6)/L, and the viral load in tonsilar tissue decreased to <40 copies/mg of tissue at month 24. A low level of HIV-1 replication could explain the lack of immunologic response in patients with apparent virological response. SN - 1058-4838 UR - https://www.unboundmedicine.com/medline/citation/10671348/Residual_low_level_viral_replication_could_explain_discrepancies_between_viral_load_and_CD4+_cell_response_in_human_immunodeficiency_virus_infected_patients_receiving_antiretroviral_therapy_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/313660 DB - PRIME DP - Unbound Medicine ER -