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Evaluation of a gonococcal serologic test.
Am J Clin Pathol. 1979 Feb; 71(2):184-9.AJ

Abstract

The fluorescent gonorrhea test--heated (FGT-H), an indirect immunofluorescent method for detecting the presence of antigonococcal antibodies in serum, was evaluated in 1,000 women referred to a private clinic for the termination of pregnancy, 202 women treated at a municipal venereal disease clinic, and six women hospitalized with gonococcal bacteremia. The test was positive for 17.7% of private outpatients, even though gonococci were cultured from only 1.1% of these women, and another 5.1% had histories of gonococcal infection. Positive test results were found for 68.3% of the women in the venereal disease clinic population, in which the prevalence of gonococcal infection was 36.1% and an additional 25.2% had had gonorrhea previously. The test was positive for all six patients with gonococcemia. The sensitivity of the test in the low-risk population was 72.7%, which was not significantly different from the sensitivity of 84% in the high-risk population. Specificity of the test was 83% in low-risk patients, but only 41% in high-risk patients. These findings indicate that a negative test is a highly reliable means for excluding gonorrhea in populations of low-risk women. The predictive value of a positive test is low, ranging from 4.5% in the low-risk group to 45% in the high-risk group.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

106719

Citation

Hoffman, T A., et al. "Evaluation of a Gonococcal Serologic Test." American Journal of Clinical Pathology, vol. 71, no. 2, 1979, pp. 184-9.
Hoffman TA, Damus AJ, Sands L. Evaluation of a gonococcal serologic test. Am J Clin Pathol. 1979;71(2):184-9.
Hoffman, T. A., Damus, A. J., & Sands, L. (1979). Evaluation of a gonococcal serologic test. American Journal of Clinical Pathology, 71(2), 184-9.
Hoffman TA, Damus AJ, Sands L. Evaluation of a Gonococcal Serologic Test. Am J Clin Pathol. 1979;71(2):184-9. PubMed PMID: 106719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of a gonococcal serologic test. AU - Hoffman,T A, AU - Damus,A J, AU - Sands,L, PY - 1979/2/1/pubmed PY - 1979/2/1/medline PY - 1979/2/1/entrez SP - 184 EP - 9 JF - American journal of clinical pathology JO - Am. J. Clin. Pathol. VL - 71 IS - 2 N2 - The fluorescent gonorrhea test--heated (FGT-H), an indirect immunofluorescent method for detecting the presence of antigonococcal antibodies in serum, was evaluated in 1,000 women referred to a private clinic for the termination of pregnancy, 202 women treated at a municipal venereal disease clinic, and six women hospitalized with gonococcal bacteremia. The test was positive for 17.7% of private outpatients, even though gonococci were cultured from only 1.1% of these women, and another 5.1% had histories of gonococcal infection. Positive test results were found for 68.3% of the women in the venereal disease clinic population, in which the prevalence of gonococcal infection was 36.1% and an additional 25.2% had had gonorrhea previously. The test was positive for all six patients with gonococcemia. The sensitivity of the test in the low-risk population was 72.7%, which was not significantly different from the sensitivity of 84% in the high-risk population. Specificity of the test was 83% in low-risk patients, but only 41% in high-risk patients. These findings indicate that a negative test is a highly reliable means for excluding gonorrhea in populations of low-risk women. The predictive value of a positive test is low, ranging from 4.5% in the low-risk group to 45% in the high-risk group. SN - 0002-9173 UR - https://www.unboundmedicine.com/medline/citation/106719/Evaluation_of_a_gonococcal_serologic_test L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1093/ajcp/71.2.184 DB - PRIME DP - Unbound Medicine ER -