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Ulcerative colitis in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival.

Abstract

BACKGROUND

There is significant geographic variation in the reported incidence of ulcerative colitis.

AIMS

To update the incidence and prevalence of ulcerative colitis in Olmsted County, Minnesota, examine temporal trends, and determine overall survival.

PATIENTS

All Olmsted County residents diagnosed with ulcerative colitis between 1940 and 1993 (incidence cases), and all residents with ulcerative colitis alive on 1 January 1991 (prevalence cases).

METHODS

Incidence and prevalence rates were adjusted using 1990 US census figures for whites. The effects of age, sex, and calendar year on incidence rates were evaluated using Poisson regression. Survival from diagnosis was compared with that expected for US north-central whites.

RESULTS

Between 1940 and 1993, 278 incidence cases were identified, for an adjusted incidence rate of 7.6 cases per 100 000 person years (95% confidence interval (CI), 6.7 to 8.5). On 1 January 1991, there were 218 residents with definite or probable ulcerative colitis, for an adjusted prevalence rate of 229 cases per 100 000 (95% CI, 198 to 260). Increased incidence rates were associated with later calendar years (p<0.002), younger age (p<0.0001), urban residence (p<0.0001), and male sex (p<0.003). Overall survival was similar to that expected (p>0.2).

CONCLUSIONS

The overall incidence rate of ulcerative colitis in Olmsted County increased until the 1970s, and remained stable thereafter. Incidence rates among men and urban residents were significantly higher. The prevalence rate in Rochester in 1991 was 19% higher than that in 1980. Overall survival was similar to that of the general population.

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  • Authors+Show Affiliations

    ,

    Division of Gastroenterology and Hepatology, Inflammatory Bowel Disease Clinic, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.

    , , , ,

    Source

    Gut 46:3 2000 Mar pg 336-43

    MeSH

    Adolescent
    Adult
    Age Distribution
    Aged
    Aged, 80 and over
    Child
    Cohort Studies
    Colitis, Ulcerative
    Female
    Humans
    Incidence
    Male
    Middle Aged
    Minnesota
    Prevalence
    Sex Distribution
    Survival Rate

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    10673294

    Citation

    Loftus, E V., et al. "Ulcerative Colitis in Olmsted County, Minnesota, 1940-1993: Incidence, Prevalence, and Survival." Gut, vol. 46, no. 3, 2000, pp. 336-43.
    Loftus EV, Silverstein MD, Sandborn WJ, et al. Ulcerative colitis in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival. Gut. 2000;46(3):336-43.
    Loftus, E. V., Silverstein, M. D., Sandborn, W. J., Tremaine, W. J., Harmsen, W. S., & Zinsmeister, A. R. (2000). Ulcerative colitis in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival. Gut, 46(3), pp. 336-43.
    Loftus EV, et al. Ulcerative Colitis in Olmsted County, Minnesota, 1940-1993: Incidence, Prevalence, and Survival. Gut. 2000;46(3):336-43. PubMed PMID: 10673294.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Ulcerative colitis in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival. AU - Loftus,E V,Jr AU - Silverstein,M D, AU - Sandborn,W J, AU - Tremaine,W J, AU - Harmsen,W S, AU - Zinsmeister,A R, PY - 2000/2/15/pubmed PY - 2000/3/25/medline PY - 2000/2/15/entrez SP - 336 EP - 43 JF - Gut JO - Gut VL - 46 IS - 3 N2 - BACKGROUND: There is significant geographic variation in the reported incidence of ulcerative colitis. AIMS: To update the incidence and prevalence of ulcerative colitis in Olmsted County, Minnesota, examine temporal trends, and determine overall survival. PATIENTS: All Olmsted County residents diagnosed with ulcerative colitis between 1940 and 1993 (incidence cases), and all residents with ulcerative colitis alive on 1 January 1991 (prevalence cases). METHODS: Incidence and prevalence rates were adjusted using 1990 US census figures for whites. The effects of age, sex, and calendar year on incidence rates were evaluated using Poisson regression. Survival from diagnosis was compared with that expected for US north-central whites. RESULTS: Between 1940 and 1993, 278 incidence cases were identified, for an adjusted incidence rate of 7.6 cases per 100 000 person years (95% confidence interval (CI), 6.7 to 8.5). On 1 January 1991, there were 218 residents with definite or probable ulcerative colitis, for an adjusted prevalence rate of 229 cases per 100 000 (95% CI, 198 to 260). Increased incidence rates were associated with later calendar years (p<0.002), younger age (p<0.0001), urban residence (p<0.0001), and male sex (p<0.003). Overall survival was similar to that expected (p>0.2). CONCLUSIONS: The overall incidence rate of ulcerative colitis in Olmsted County increased until the 1970s, and remained stable thereafter. Incidence rates among men and urban residents were significantly higher. The prevalence rate in Rochester in 1991 was 19% higher than that in 1980. Overall survival was similar to that of the general population. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/10673294/Ulcerative_colitis_in_Olmsted_County_Minnesota_1940_1993:_incidence_prevalence_and_survival_ L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&amp;pmid=10673294 DB - PRIME DP - Unbound Medicine ER -