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A cohort study of Plasmodium falciparum diversity during the dry season in Ndiop, a Senegalese village with seasonal, mesoendemic malaria.
Trans R Soc Trop Med Hyg. 1999 Jul-Aug; 93(4):375-80.TR

Abstract

Prolonged carriage of Plasmodium falciparum in humans during the dry season is critical for parasite survival, as the infected subjects constitute a major reservoir in the absence of transmission. Yet, very little is known about the host/parasite interactions contributing to parasite persistence. In order to study the characteristics of P. falciparum infections during the dry season, we have genotyped parasites collected from untreated, asymptomatic individuals during 3 cross-sectional surveys conducted during the dry season in Ndiop, a Senegalese village with seasonal, mesoendemic malaria. Monthly entomological surveillance did not detect any transmission during that period. Parasite prevalence decreased markedly in the children aged < 7 years after 7 months of undetected transmission, but was stable in older children and adults throughout the dry season. In all chronically infected individuals, infection complexity remained stable, but there were substantial fluctuations of individual genotype(s), reflecting complex dynamics of multiple-clone infections during chronic asymptomatic parasite carriage. This fluctuation resulted in changes in the msp1 and msp2 allelic distribution within the cohort after 7 months of undetected transmission, contrasting with the stability observed during the preceding rainy season in that village.

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Authors+Show Affiliations

Zwetyenga J
Unité d'Immunologie Moléculaire des Parasites, Institut Pasteur, Paris, France.
Rogier C
No affiliation info available
Spiegel A
No affiliation info available
Fontenille D
No affiliation info available
Trape JF
No affiliation info available
Mercereau-Puijalon O
No affiliation info available

MeSH

AdolescentAdultAge DistributionAnimalsAntigens, ProtozoanChildCohort StudiesDisease ReservoirsFollow-Up StudiesGene FrequencyGenotypeHumansLongitudinal StudiesMalaria, FalciparumMerozoite Surface Protein 1Middle AgedPlasmodium falciparumPolymerase Chain ReactionPrevalenceProtozoan ProteinsSeasonsSenegal

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10674080

Citation

Zwetyenga, J, et al. "A Cohort Study of Plasmodium Falciparum Diversity During the Dry Season in Ndiop, a Senegalese Village With Seasonal, Mesoendemic Malaria." Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 93, no. 4, 1999, pp. 375-80.
Zwetyenga J, Rogier C, Spiegel A, et al. A cohort study of Plasmodium falciparum diversity during the dry season in Ndiop, a Senegalese village with seasonal, mesoendemic malaria. Trans R Soc Trop Med Hyg. 1999;93(4):375-80.
Zwetyenga, J., Rogier, C., Spiegel, A., Fontenille, D., Trape, J. F., & Mercereau-Puijalon, O. (1999). A cohort study of Plasmodium falciparum diversity during the dry season in Ndiop, a Senegalese village with seasonal, mesoendemic malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 93(4), 375-80.
Zwetyenga J, et al. A Cohort Study of Plasmodium Falciparum Diversity During the Dry Season in Ndiop, a Senegalese Village With Seasonal, Mesoendemic Malaria. Trans R Soc Trop Med Hyg. 1999 Jul-Aug;93(4):375-80. PubMed PMID: 10674080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A cohort study of Plasmodium falciparum diversity during the dry season in Ndiop, a Senegalese village with seasonal, mesoendemic malaria. AU - Zwetyenga,J, AU - Rogier,C, AU - Spiegel,A, AU - Fontenille,D, AU - Trape,J F, AU - Mercereau-Puijalon,O, PY - 2000/2/16/pubmed PY - 2000/2/26/medline PY - 2000/2/16/entrez SP - 375 EP - 80 JF - Transactions of the Royal Society of Tropical Medicine and Hygiene JO - Trans R Soc Trop Med Hyg VL - 93 IS - 4 N2 - Prolonged carriage of Plasmodium falciparum in humans during the dry season is critical for parasite survival, as the infected subjects constitute a major reservoir in the absence of transmission. Yet, very little is known about the host/parasite interactions contributing to parasite persistence. In order to study the characteristics of P. falciparum infections during the dry season, we have genotyped parasites collected from untreated, asymptomatic individuals during 3 cross-sectional surveys conducted during the dry season in Ndiop, a Senegalese village with seasonal, mesoendemic malaria. Monthly entomological surveillance did not detect any transmission during that period. Parasite prevalence decreased markedly in the children aged < 7 years after 7 months of undetected transmission, but was stable in older children and adults throughout the dry season. In all chronically infected individuals, infection complexity remained stable, but there were substantial fluctuations of individual genotype(s), reflecting complex dynamics of multiple-clone infections during chronic asymptomatic parasite carriage. This fluctuation resulted in changes in the msp1 and msp2 allelic distribution within the cohort after 7 months of undetected transmission, contrasting with the stability observed during the preceding rainy season in that village. SN - 0035-9203 UR - https://www.unboundmedicine.com/medline/citation/10674080/A_cohort_study_of_Plasmodium_falciparum_diversity_during_the_dry_season_in_Ndiop_a_Senegalese_village_with_seasonal_mesoendemic_malaria_ L2 - https://academic.oup.com/trstmh/article-lookup/doi/10.1016/s0035-9203(99)90122-0 DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓16]

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