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The fate of hair follicle melanocytes during the hair growth cycle.J Investig Dermatol Symp Proc. 1999 Dec; 4(3):323-32.JI
Abstract
The fate of the follicular pigmentary unit during the hair growth cycle has long been one of the great enigmas of both hair follicle and pigment cell biology. Although melanocytes are distributed in several different compartments of the anagen hair follicle, melanogenically active cells are located only in the hair bulb, where they are directly involved in hair shaft pigmentation. These pigment cells are readily detectable only when they become melanogenically active during anagen III of the hair growth cycle. Thus, their status during hair follicle regression (catagen), when melanogenesis is switched off, until they re-appear again as pigment-producing cells in the anagen III hair follicle, has remained poorly defined. Historically, it has been proposed that hair bulb melanocytes adopt a self-perpetuating, catagen-resistant strategy of de-differentiation during hair follicle regression and re-differentiation upon entry into a new anagen phase; however, this explanation remains problematic in the absence of evidence for de-differentiation/re-differentiation plasticity in most nonmalignant cell systems.
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Pub Type(s)
Journal Article
Review
Language
eng
PubMed ID
10674391
Citation
Tobin, D J., et al. "The Fate of Hair Follicle Melanocytes During the Hair Growth Cycle." The Journal of Investigative Dermatology. Symposium Proceedings, vol. 4, no. 3, 1999, pp. 323-32.
Tobin DJ, Slominski A, Botchkarev V, et al. The fate of hair follicle melanocytes during the hair growth cycle. J Investig Dermatol Symp Proc. 1999;4(3):323-32.
Tobin, D. J., Slominski, A., Botchkarev, V., & Paus, R. (1999). The fate of hair follicle melanocytes during the hair growth cycle. The Journal of Investigative Dermatology. Symposium Proceedings, 4(3), 323-32.
Tobin DJ, et al. The Fate of Hair Follicle Melanocytes During the Hair Growth Cycle. J Investig Dermatol Symp Proc. 1999;4(3):323-32. PubMed PMID: 10674391.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - The fate of hair follicle melanocytes during the hair growth cycle.
AU - Tobin,D J,
AU - Slominski,A,
AU - Botchkarev,V,
AU - Paus,R,
PY - 2000/2/16/pubmed
PY - 2000/3/18/medline
PY - 2000/2/16/entrez
SP - 323
EP - 32
JF - The journal of investigative dermatology. Symposium proceedings
JO - J Investig Dermatol Symp Proc
VL - 4
IS - 3
N2 - The fate of the follicular pigmentary unit during the hair growth cycle has long been one of the great enigmas of both hair follicle and pigment cell biology. Although melanocytes are distributed in several different compartments of the anagen hair follicle, melanogenically active cells are located only in the hair bulb, where they are directly involved in hair shaft pigmentation. These pigment cells are readily detectable only when they become melanogenically active during anagen III of the hair growth cycle. Thus, their status during hair follicle regression (catagen), when melanogenesis is switched off, until they re-appear again as pigment-producing cells in the anagen III hair follicle, has remained poorly defined. Historically, it has been proposed that hair bulb melanocytes adopt a self-perpetuating, catagen-resistant strategy of de-differentiation during hair follicle regression and re-differentiation upon entry into a new anagen phase; however, this explanation remains problematic in the absence of evidence for de-differentiation/re-differentiation plasticity in most nonmalignant cell systems.
SN - 1087-0024
UR - https://www.unboundmedicine.com/medline/citation/10674391/The_fate_of_hair_follicle_melanocytes_during_the_hair_growth_cycle_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S1087-0024(15)30292-6
DB - PRIME
DP - Unbound Medicine
ER -
