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Specific serum IgG, IgM and IgA antibodies to human papillomavirus types 6, 11, 16, 18 and 31 virus-like particles in human immunodeficiency virus-seropositive women.
J Gen Virol. 2000 Mar; 81(Pt 3):701-8.JG

Abstract

To evaluate the humoral immune response to human papillomavirus (HPV) in women infected with human immunodeficiency virus (HIV), serum samples of 83 HIV-positive individuals were analysed by ELISA for specific antibodies of the isotypes IgG, IgA and IgM recognizing HPV-6, -11, -16, -18 and -31 L1 virus-like particles (VLPs). Papillomavirus-related lesions were present in 30 of 83 HIV-positive women. Twenty-one women (25%) presented with high-/intermediate-grade anogenital squamous intraepithelial lesions. PCR analysis and sequencing for HPV typing was done from biopsy specimens of 18 women; PCR-positive results were obtained in 90% of cases. In addition, HPV DNA hybrid capture assays were performed from cervical swabs of 58 HIV-positive women, 53% of whom had a positive result for high-risk HPV. Overall, positive IgG reactivity to HPV-6/-11 and HPV-16/-18/-31 was seen in 19%/31% and 49%/30%/24% of HIV-positive women, respectively. HPV-seropositivity was even higher than in 48 HIV-negative cervical intraepithelial neoplasia/cancer patients with percentages as follows: 8%/2% and 31%/15%/15%. This difference was significant for HPV-16 (P=0.046). IgA responses were comparable to IgG. IgM responses were low. The extraordinarily high rate of antibodies to the capsid protein L1 of high-risk HPVs (HPV-16, -18 and/or -31) in 58% of HIV-positive women compared to 19% (P=0.00001) of 102 healthy HIV-negative control women suggests a high lifetime cumulative exposure to HPV and increased expression of capsid proteins due to cellular immunodeficiency in HIV-infected women.

Authors+Show Affiliations

Department of Dermatology, University Clinic, Anichstrabetae 35, A-6020 Innsbruck, Austria. anton.petter@uibk.ac.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10675407

Citation

Petter, A, et al. "Specific Serum IgG, IgM and IgA Antibodies to Human Papillomavirus Types 6, 11, 16, 18 and 31 Virus-like Particles in Human Immunodeficiency Virus-seropositive Women." The Journal of General Virology, vol. 81, no. Pt 3, 2000, pp. 701-8.
Petter A, Heim K, Guger M, et al. Specific serum IgG, IgM and IgA antibodies to human papillomavirus types 6, 11, 16, 18 and 31 virus-like particles in human immunodeficiency virus-seropositive women. J Gen Virol. 2000;81(Pt 3):701-8.
Petter, A., Heim, K., Guger, M., Ciresa-Kö Nig, A., Christensen, N., Sarcletti, M., Wieland, U., Pfister, H., Zangerle, R., & Höpfl, R. (2000). Specific serum IgG, IgM and IgA antibodies to human papillomavirus types 6, 11, 16, 18 and 31 virus-like particles in human immunodeficiency virus-seropositive women. The Journal of General Virology, 81(Pt 3), 701-8.
Petter A, et al. Specific Serum IgG, IgM and IgA Antibodies to Human Papillomavirus Types 6, 11, 16, 18 and 31 Virus-like Particles in Human Immunodeficiency Virus-seropositive Women. J Gen Virol. 2000;81(Pt 3):701-8. PubMed PMID: 10675407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Specific serum IgG, IgM and IgA antibodies to human papillomavirus types 6, 11, 16, 18 and 31 virus-like particles in human immunodeficiency virus-seropositive women. AU - Petter,A, AU - Heim,K, AU - Guger,M, AU - Ciresa-Kö Nig,A, AU - Christensen,N, AU - Sarcletti,M, AU - Wieland,U, AU - Pfister,H, AU - Zangerle,R, AU - Höpfl,R, PY - 2000/2/17/pubmed PY - 2000/4/1/medline PY - 2000/2/17/entrez SP - 701 EP - 8 JF - The Journal of general virology JO - J Gen Virol VL - 81 IS - Pt 3 N2 - To evaluate the humoral immune response to human papillomavirus (HPV) in women infected with human immunodeficiency virus (HIV), serum samples of 83 HIV-positive individuals were analysed by ELISA for specific antibodies of the isotypes IgG, IgA and IgM recognizing HPV-6, -11, -16, -18 and -31 L1 virus-like particles (VLPs). Papillomavirus-related lesions were present in 30 of 83 HIV-positive women. Twenty-one women (25%) presented with high-/intermediate-grade anogenital squamous intraepithelial lesions. PCR analysis and sequencing for HPV typing was done from biopsy specimens of 18 women; PCR-positive results were obtained in 90% of cases. In addition, HPV DNA hybrid capture assays were performed from cervical swabs of 58 HIV-positive women, 53% of whom had a positive result for high-risk HPV. Overall, positive IgG reactivity to HPV-6/-11 and HPV-16/-18/-31 was seen in 19%/31% and 49%/30%/24% of HIV-positive women, respectively. HPV-seropositivity was even higher than in 48 HIV-negative cervical intraepithelial neoplasia/cancer patients with percentages as follows: 8%/2% and 31%/15%/15%. This difference was significant for HPV-16 (P=0.046). IgA responses were comparable to IgG. IgM responses were low. The extraordinarily high rate of antibodies to the capsid protein L1 of high-risk HPVs (HPV-16, -18 and/or -31) in 58% of HIV-positive women compared to 19% (P=0.00001) of 102 healthy HIV-negative control women suggests a high lifetime cumulative exposure to HPV and increased expression of capsid proteins due to cellular immunodeficiency in HIV-infected women. SN - 0022-1317 UR - https://www.unboundmedicine.com/medline/citation/10675407/Specific_serum_IgG_IgM_and_IgA_antibodies_to_human_papillomavirus_types_6_11_16_18_and_31_virus_like_particles_in_human_immunodeficiency_virus_seropositive_women_ L2 - http://jgv.microbiologyresearch.org/pubmed/content/journal/jgv/10.1099/0022-1317-81-3-701 DB - PRIME DP - Unbound Medicine ER -