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Gender-specific association of the angiotensin converting enzyme gene with Alzheimer's disease.

Abstract

Epidemiological studies have demonstrated that risk factors for vascular disease are also risk factors for Alzheimer's disease (AD). The gene for the angiotensin converting enzyme (ACE) has recently been reported to be associated with risk for AD. We have investigated the possibility of such an association in 98 clinic-based and 73 community-based AD cases versus 175 community-based controls and find a gender-specific association of ACE genotype with AD in the female clinic population. These data suggest that gender may interact with genetic factors to influence risk for AD. Gender-specific risk for AD has been previously reported, and a biological rationale for involvement of ACE in the AD process is supported by studies exploring the relationship between AD and vascular risk factors such as hypertension. However, the results may also be a consequence of the known anomalies that arise in genetic association studies as a consequence of sample selection.

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  • Authors+Show Affiliations

    ,

    Roskamp Institute, University of South Florida, 3515 E. Fletcher Avenue, Tampa, FL 336113, USA. fcrawfor@com1.med.usf.edu

    , , , , ,

    Source

    Neuroscience letters 280:3 2000 Feb 25 pg 215-9

    MeSH

    Alzheimer Disease
    Case-Control Studies
    Chromosome Mapping
    Chromosomes, Human, Pair 17
    Confidence Intervals
    Female
    Florida
    Gene Frequency
    Genotype
    Humans
    Male
    Peptidyl-Dipeptidase A
    Polymorphism, Genetic
    Reference Values
    Risk Factors
    Sex Characteristics

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    10675799

    Citation

    Crawford, F, et al. "Gender-specific Association of the Angiotensin Converting Enzyme Gene With Alzheimer's Disease." Neuroscience Letters, vol. 280, no. 3, 2000, pp. 215-9.
    Crawford F, Abdullah L, Schinka J, et al. Gender-specific association of the angiotensin converting enzyme gene with Alzheimer's disease. Neurosci Lett. 2000;280(3):215-9.
    Crawford, F., Abdullah, L., Schinka, J., Suo, Z., Gold, M., Duara, R., & Mullan, M. (2000). Gender-specific association of the angiotensin converting enzyme gene with Alzheimer's disease. Neuroscience Letters, 280(3), pp. 215-9.
    Crawford F, et al. Gender-specific Association of the Angiotensin Converting Enzyme Gene With Alzheimer's Disease. Neurosci Lett. 2000 Feb 25;280(3):215-9. PubMed PMID: 10675799.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Gender-specific association of the angiotensin converting enzyme gene with Alzheimer's disease. AU - Crawford,F, AU - Abdullah,L, AU - Schinka,J, AU - Suo,Z, AU - Gold,M, AU - Duara,R, AU - Mullan,M, PY - 2000/2/17/pubmed PY - 2000/2/17/medline PY - 2000/2/17/entrez SP - 215 EP - 9 JF - Neuroscience letters JO - Neurosci. Lett. VL - 280 IS - 3 N2 - Epidemiological studies have demonstrated that risk factors for vascular disease are also risk factors for Alzheimer's disease (AD). The gene for the angiotensin converting enzyme (ACE) has recently been reported to be associated with risk for AD. We have investigated the possibility of such an association in 98 clinic-based and 73 community-based AD cases versus 175 community-based controls and find a gender-specific association of ACE genotype with AD in the female clinic population. These data suggest that gender may interact with genetic factors to influence risk for AD. Gender-specific risk for AD has been previously reported, and a biological rationale for involvement of ACE in the AD process is supported by studies exploring the relationship between AD and vascular risk factors such as hypertension. However, the results may also be a consequence of the known anomalies that arise in genetic association studies as a consequence of sample selection. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/10675799/Gender_specific_association_of_the_angiotensin_converting_enzyme_gene_with_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304394000007916 DB - PRIME DP - Unbound Medicine ER -