Tags

Type your tag names separated by a space and hit enter

Multiple antioxidants in the prevention and treatment of neurodegenerative disease: analysis of biologic rationale.
Curr Opin Neurol. 1999 Dec; 12(6):761-70.CO

Abstract

Parkinson's disease and Alzheimer's disease are major progressive neurologic disorders, the risk of which increases with advancing age (65 years and over). In familial cases, however, early onset of disease (35-65 years) is observed. In spite of extensive basic and chemical research on Parkinson's disease and Alzheimer's disease, no preventive or long-term effective treatment strategies are available. The analysis of existing literature suggests that oxidative stress is a major intermediary risk factor for the action of diverse groups of neurotoxins that are involved in these neurodegenerative diseases. In this review, it is proposed that the epigenetic components (mitochondria, other organelles, membranes, protein modification) rather than nuclear genes of neurons are the primary targets for the action of neurotoxins, including free radicals. In addition, a scientific rationale for using multiple antioxidants in clinical trials for the prevention of Parkinson's disease and Alzheimer's disease among high-risk populations, and as an adjunct to standard therapy in the treatment of these diseases is presented.

Links

Aggregator Full Text

Authors+Show Affiliations

Prasad KN
Center for Vitamins and Cancer Research, Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA. Kedar.Prasad@UCHSC.edu
Cole WC
No affiliation info available
Hovland AR
No affiliation info available
Prasad KC
No affiliation info available
Nahreini P
No affiliation info available
Kumar B
No affiliation info available
Edwards-Prasad J
No affiliation info available
Andreatta CP
No affiliation info available

MeSH

Alzheimer DiseaseAnimalsAntioxidantsHumansNeurodegenerative DiseasesParkinson Disease

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10676761

Citation

Prasad, K N., et al. "Multiple Antioxidants in the Prevention and Treatment of Neurodegenerative Disease: Analysis of Biologic Rationale." Current Opinion in Neurology, vol. 12, no. 6, 1999, pp. 761-70.
Prasad KN, Cole WC, Hovland AR, et al. Multiple antioxidants in the prevention and treatment of neurodegenerative disease: analysis of biologic rationale. Curr Opin Neurol. 1999;12(6):761-70.
Prasad, K. N., Cole, W. C., Hovland, A. R., Prasad, K. C., Nahreini, P., Kumar, B., Edwards-Prasad, J., & Andreatta, C. P. (1999). Multiple antioxidants in the prevention and treatment of neurodegenerative disease: analysis of biologic rationale. Current Opinion in Neurology, 12(6), 761-70.
Prasad KN, et al. Multiple Antioxidants in the Prevention and Treatment of Neurodegenerative Disease: Analysis of Biologic Rationale. Curr Opin Neurol. 1999;12(6):761-70. PubMed PMID: 10676761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiple antioxidants in the prevention and treatment of neurodegenerative disease: analysis of biologic rationale. AU - Prasad,K N, AU - Cole,W C, AU - Hovland,A R, AU - Prasad,K C, AU - Nahreini,P, AU - Kumar,B, AU - Edwards-Prasad,J, AU - Andreatta,C P, PY - 2000/2/17/pubmed PY - 2000/3/18/medline PY - 2000/2/17/entrez SP - 761 EP - 70 JF - Current opinion in neurology JO - Curr Opin Neurol VL - 12 IS - 6 N2 - Parkinson's disease and Alzheimer's disease are major progressive neurologic disorders, the risk of which increases with advancing age (65 years and over). In familial cases, however, early onset of disease (35-65 years) is observed. In spite of extensive basic and chemical research on Parkinson's disease and Alzheimer's disease, no preventive or long-term effective treatment strategies are available. The analysis of existing literature suggests that oxidative stress is a major intermediary risk factor for the action of diverse groups of neurotoxins that are involved in these neurodegenerative diseases. In this review, it is proposed that the epigenetic components (mitochondria, other organelles, membranes, protein modification) rather than nuclear genes of neurons are the primary targets for the action of neurotoxins, including free radicals. In addition, a scientific rationale for using multiple antioxidants in clinical trials for the prevention of Parkinson's disease and Alzheimer's disease among high-risk populations, and as an adjunct to standard therapy in the treatment of these diseases is presented. SN - 1350-7540 UR - https://www.unboundmedicine.com/medline/citation/10676761/Multiple_antioxidants_in_the_prevention_and_treatment_of_neurodegenerative_disease:_analysis_of_biologic_rationale_ L2 - https://doi.org/10.1097/00019052-199912000-00017 DB - PRIME DP - Unbound Medicine ER -