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Significantly higher levels of oxidized LDL autoantibody in coronary artery disease patients.
Zhonghua Yi Xue Za Zhi (Taipei). 2000 Feb; 63(2):101-6.ZY

Abstract

BACKGROUND

Increasing evidence shows that oxidized low-density lipoprotein (ox-LDL) might play an important role in the pathogenesis of atherosclerosis. Ox-LDL is immunogenic and induces an autoantibody, which we used as a tool for measuring the content of ox-LDL in vivo.

METHODS

Patients who were admitted for diagnostic cardiac catheterization for typical or atypical angina pectoris were enrolled in this study. After fasting for 12 hours, a venous blood sample was drawn from the antecubital vein for testing triglyceride, total cholesterol, LDL cholesterol, high-density lipoprotein (HDL) cholesterol, and ox-LDL autoantibody. The ox-LDL autoantibody was quantified using an enzyme linked immunosorbent assay. All patients underwent coronary angiography. Those who had more than 50% angiographic coronary luminal stenosis, were grouped into the coronary artery disease (CAD) group.

RESULTS

Sixty-four patients were enrolled in the study (male/female = 46/18; mean +/- standard deviation, age, 64 +/- 9 years). The CAD group had a significantly higher level of ox-LDL autoantibody than the non-CAD group (494.0 +/- 355.0 mU/ml vs 258.1 +/- 196.8 mU/ml, p = 0.004). However, the other lipid profiles including triglyceride, total cholesterol, LDL-cholesterol and HDL-cholesterol were not statistically different between the two groups. Forty-six patients in this study had an arterial blood sample taken from the femoral artery for testing ox-LDL autoantibody. There was no significant difference between the arterial and venous samples of ox-LDL autoantibody (385.2 +/- 333.3 mU/ml vs 399.3 +/- 339.5 mU/ml, n = 46, p = 0.530).

CONCLUSIONS

Ox-LDL autoantibody was significantly higher in the CAD group. Ox-LDL may prove to play a key role in the pathogenesis of atherosclerosis. Further study of Ox-LDL and its role in the process of atherosclerosis is warranted.

Authors+Show Affiliations

Department of Medicine, Taichung Veterans General Hospital, Taiwan, ROC.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10677919

Citation

Liang, K W., et al. "Significantly Higher Levels of Oxidized LDL Autoantibody in Coronary Artery Disease Patients." Zhonghua Yi Xue Za Zhi = Chinese Medical Journal; Free China Ed, vol. 63, no. 2, 2000, pp. 101-6.
Liang KW, Huang JL, Kao CH, et al. Significantly higher levels of oxidized LDL autoantibody in coronary artery disease patients. Zhonghua Yi Xue Za Zhi (Taipei). 2000;63(2):101-6.
Liang, K. W., Huang, J. L., Kao, C. H., Hsueh, C. W., Ho, H. Y., Lee, W. L., Wang, K. Y., Huang, D. S., Chen, Y. T., & Ting, C. T. (2000). Significantly higher levels of oxidized LDL autoantibody in coronary artery disease patients. Zhonghua Yi Xue Za Zhi = Chinese Medical Journal; Free China Ed, 63(2), 101-6.
Liang KW, et al. Significantly Higher Levels of Oxidized LDL Autoantibody in Coronary Artery Disease Patients. Zhonghua Yi Xue Za Zhi (Taipei). 2000;63(2):101-6. PubMed PMID: 10677919.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Significantly higher levels of oxidized LDL autoantibody in coronary artery disease patients. AU - Liang,K W, AU - Huang,J L, AU - Kao,C H, AU - Hsueh,C W, AU - Ho,H Y, AU - Lee,W L, AU - Wang,K Y, AU - Huang,D S, AU - Chen,Y T, AU - Ting,C T, PY - 2000/3/4/pubmed PY - 2000/3/4/medline PY - 2000/3/4/entrez SP - 101 EP - 6 JF - Zhonghua yi xue za zhi = Chinese medical journal; Free China ed JO - Zhonghua Yi Xue Za Zhi (Taipei) VL - 63 IS - 2 N2 - BACKGROUND: Increasing evidence shows that oxidized low-density lipoprotein (ox-LDL) might play an important role in the pathogenesis of atherosclerosis. Ox-LDL is immunogenic and induces an autoantibody, which we used as a tool for measuring the content of ox-LDL in vivo. METHODS: Patients who were admitted for diagnostic cardiac catheterization for typical or atypical angina pectoris were enrolled in this study. After fasting for 12 hours, a venous blood sample was drawn from the antecubital vein for testing triglyceride, total cholesterol, LDL cholesterol, high-density lipoprotein (HDL) cholesterol, and ox-LDL autoantibody. The ox-LDL autoantibody was quantified using an enzyme linked immunosorbent assay. All patients underwent coronary angiography. Those who had more than 50% angiographic coronary luminal stenosis, were grouped into the coronary artery disease (CAD) group. RESULTS: Sixty-four patients were enrolled in the study (male/female = 46/18; mean +/- standard deviation, age, 64 +/- 9 years). The CAD group had a significantly higher level of ox-LDL autoantibody than the non-CAD group (494.0 +/- 355.0 mU/ml vs 258.1 +/- 196.8 mU/ml, p = 0.004). However, the other lipid profiles including triglyceride, total cholesterol, LDL-cholesterol and HDL-cholesterol were not statistically different between the two groups. Forty-six patients in this study had an arterial blood sample taken from the femoral artery for testing ox-LDL autoantibody. There was no significant difference between the arterial and venous samples of ox-LDL autoantibody (385.2 +/- 333.3 mU/ml vs 399.3 +/- 339.5 mU/ml, n = 46, p = 0.530). CONCLUSIONS: Ox-LDL autoantibody was significantly higher in the CAD group. Ox-LDL may prove to play a key role in the pathogenesis of atherosclerosis. Further study of Ox-LDL and its role in the process of atherosclerosis is warranted. SN - 0578-1337 UR - https://www.unboundmedicine.com/medline/citation/10677919/Significantly_higher_levels_of_oxidized_LDL_autoantibody_in_coronary_artery_disease_patients_ DB - PRIME DP - Unbound Medicine ER -