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Supraspinal D2 receptor involved in antinociception induced by l-tetrahydropalmatine.
Zhongguo Yao Li Xue Bao. 1999 Aug; 20(8):715-9.ZY

Abstract

AIM

To study the role of dopamine (DA) receptors in l-tetrahydropalmatine (l-THP)-induced antinociception.

METHODS

The intraperitoneal (i.p.) and intrathecal (ith) injections were used to give the drugs. The tail-flick test was used to assess the nociceptive threshold of rats.

RESULTS

By i.p. injection, l-THP (10, 20, 40 mg.kg-1) as well as D2 receptor antagonist spiperone (1, 2, 3 mg.kg-1) produced dose-dependent antinociceptive effects on the nociception of rats, while D2 receptor agonist quinpirole, D1 receptor agonist SKF38393, and D1 receptor antagonist Sch-23390 showed no antinociception. Moreover, l-THP- or spiperone-induced antinociception was markedly attenuated by quinpirole (2, 3 mg.kg-1) but not SKF38393 or naloxone. On the other hand, ith quinpirole (20, 30, 40 micrograms.kg-1) also induced a dose-dependent antinociception, while ith l-THP, spiperone, SKF38393, and Sch-23390 did not exhibit any antinociception. Furthermore, ith spiperone (20, 30, 40 micrograms.kg-1) but not Sch-23390 dose-dependently antagonised the antinociception induced by quinpirole. l-THP (ith, 100, 200, 300 micrograms.kg-1) also dramatically attenuated the quinpirole-induced antinociception with a dose-dependent relationship.

CONCLUSION

Activating the spinal D2 receptor or blocking the supraspinal D2 receptor produces antinociception. D1 receptor might be not directly involved in the antinociception. l-THP (as a D2 antagonist) as well as spiperone produces antinociception via blocking the supraspinal D2 receptor.

Authors+Show Affiliations

Department of Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10678104

Citation

Hu, J Y., and G Z. Jin. "Supraspinal D2 Receptor Involved in Antinociception Induced By L-tetrahydropalmatine." Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, vol. 20, no. 8, 1999, pp. 715-9.
Hu JY, Jin GZ. Supraspinal D2 receptor involved in antinociception induced by l-tetrahydropalmatine. Zhongguo Yao Li Xue Bao. 1999;20(8):715-9.
Hu, J. Y., & Jin, G. Z. (1999). Supraspinal D2 receptor involved in antinociception induced by l-tetrahydropalmatine. Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, 20(8), 715-9.
Hu JY, Jin GZ. Supraspinal D2 Receptor Involved in Antinociception Induced By L-tetrahydropalmatine. Zhongguo Yao Li Xue Bao. 1999;20(8):715-9. PubMed PMID: 10678104.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Supraspinal D2 receptor involved in antinociception induced by l-tetrahydropalmatine. AU - Hu,J Y, AU - Jin,G Z, PY - 2000/4/29/pubmed PY - 2000/4/29/medline PY - 2000/4/29/entrez SP - 715 EP - 9 JF - Zhongguo yao li xue bao = Acta pharmacologica Sinica JO - Zhongguo Yao Li Xue Bao VL - 20 IS - 8 N2 - AIM: To study the role of dopamine (DA) receptors in l-tetrahydropalmatine (l-THP)-induced antinociception. METHODS: The intraperitoneal (i.p.) and intrathecal (ith) injections were used to give the drugs. The tail-flick test was used to assess the nociceptive threshold of rats. RESULTS: By i.p. injection, l-THP (10, 20, 40 mg.kg-1) as well as D2 receptor antagonist spiperone (1, 2, 3 mg.kg-1) produced dose-dependent antinociceptive effects on the nociception of rats, while D2 receptor agonist quinpirole, D1 receptor agonist SKF38393, and D1 receptor antagonist Sch-23390 showed no antinociception. Moreover, l-THP- or spiperone-induced antinociception was markedly attenuated by quinpirole (2, 3 mg.kg-1) but not SKF38393 or naloxone. On the other hand, ith quinpirole (20, 30, 40 micrograms.kg-1) also induced a dose-dependent antinociception, while ith l-THP, spiperone, SKF38393, and Sch-23390 did not exhibit any antinociception. Furthermore, ith spiperone (20, 30, 40 micrograms.kg-1) but not Sch-23390 dose-dependently antagonised the antinociception induced by quinpirole. l-THP (ith, 100, 200, 300 micrograms.kg-1) also dramatically attenuated the quinpirole-induced antinociception with a dose-dependent relationship. CONCLUSION: Activating the spinal D2 receptor or blocking the supraspinal D2 receptor produces antinociception. D1 receptor might be not directly involved in the antinociception. l-THP (as a D2 antagonist) as well as spiperone produces antinociception via blocking the supraspinal D2 receptor. SN - 0253-9756 UR - https://www.unboundmedicine.com/medline/citation/10678104/Supraspinal_D2_receptor_involved_in_antinociception_induced_by_l_tetrahydropalmatine_ L2 - http://www.chinaphar.com/1671-4083/20/715.pdf DB - PRIME DP - Unbound Medicine ER -