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Intrathecal injection of corticotropin inhibited nitric-oxide synthase-positive neuron increase in rat spinal cord after formalin-induced hyperalgesia.
Zhongguo Yao Li Xue Bao. 1999 Aug; 20(8):737-40.ZY

Abstract

AIM

To study the effects of corticotropin (Cor) on formalin-induced hyperalgesia and the change of nitric-oxide synthase (NOS)-positive neurons in spinal dorsal horn in rats.

METHODS

Measurement of pain intensity rating (PIR), NADPH-d histochemistry, and Fos immunohistochemistry were adopted.

RESULTS

The increases of NOS-positive neurons, Fos, NOS/Fos double labelling neurons of the spinal dorsal horn and the PIR after formalin injection were markedly inhibited by intrathecal injecting (ith) Cor (0.5-1.5 U), which were obviously attenuated by L-arginine (Arg, 5-15 nmol, ith), the substrate of NOS.

CONCLUSION

Cor inhibits formalin-induced hyperalgesia by the decrease of NOS-positive neurons in the spinal dorsal horn of rats.

Authors+Show Affiliations

Zhou HJ
Department of Physiology, Third Military Medical University, Chongqing, China.
Li HD
No affiliation info available
Li XC
No affiliation info available
Ruan HZ
No affiliation info available
Zhao BY
No affiliation info available

MeSH

Adrenocorticotropic HormoneAnimalsFemaleFormaldehydeHyperalgesiaInjections, SpinalMaleNeuronsNitric Oxide SynthaseNitric Oxide Synthase Type IPain MeasurementProto-Oncogene Proteins c-fosRatsRats, WistarSpinal Cord

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10678109

Citation

Zhou, H J., et al. "Intrathecal Injection of Corticotropin Inhibited Nitric-oxide Synthase-positive Neuron Increase in Rat Spinal Cord After Formalin-induced Hyperalgesia." Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, vol. 20, no. 8, 1999, pp. 737-40.
Zhou HJ, Li HD, Li XC, et al. Intrathecal injection of corticotropin inhibited nitric-oxide synthase-positive neuron increase in rat spinal cord after formalin-induced hyperalgesia. Zhongguo Yao Li Xue Bao. 1999;20(8):737-40.
Zhou, H. J., Li, H. D., Li, X. C., Ruan, H. Z., & Zhao, B. Y. (1999). Intrathecal injection of corticotropin inhibited nitric-oxide synthase-positive neuron increase in rat spinal cord after formalin-induced hyperalgesia. Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, 20(8), 737-40.
Zhou HJ, et al. Intrathecal Injection of Corticotropin Inhibited Nitric-oxide Synthase-positive Neuron Increase in Rat Spinal Cord After Formalin-induced Hyperalgesia. Zhongguo Yao Li Xue Bao. 1999;20(8):737-40. PubMed PMID: 10678109.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intrathecal injection of corticotropin inhibited nitric-oxide synthase-positive neuron increase in rat spinal cord after formalin-induced hyperalgesia. AU - Zhou,H J, AU - Li,H D, AU - Li,X C, AU - Ruan,H Z, AU - Zhao,B Y, PY - 2000/4/29/pubmed PY - 2000/4/29/medline PY - 2000/4/29/entrez SP - 737 EP - 40 JF - Zhongguo yao li xue bao = Acta pharmacologica Sinica JO - Zhongguo Yao Li Xue Bao VL - 20 IS - 8 N2 - AIM: To study the effects of corticotropin (Cor) on formalin-induced hyperalgesia and the change of nitric-oxide synthase (NOS)-positive neurons in spinal dorsal horn in rats. METHODS: Measurement of pain intensity rating (PIR), NADPH-d histochemistry, and Fos immunohistochemistry were adopted. RESULTS: The increases of NOS-positive neurons, Fos, NOS/Fos double labelling neurons of the spinal dorsal horn and the PIR after formalin injection were markedly inhibited by intrathecal injecting (ith) Cor (0.5-1.5 U), which were obviously attenuated by L-arginine (Arg, 5-15 nmol, ith), the substrate of NOS. CONCLUSION: Cor inhibits formalin-induced hyperalgesia by the decrease of NOS-positive neurons in the spinal dorsal horn of rats. SN - 0253-9756 UR - https://www.unboundmedicine.com/medline/citation/10678109/Intrathecal_injection_of_corticotropin_inhibited_nitric_oxide_synthase_positive_neuron_increase_in_rat_spinal_cord_after_formalin_induced_hyperalgesia_ DB - PRIME DP - Unbound Medicine ER -