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Effects of ramipril on cardiac gene transcription levels of angiotensin II receptors after myocardial infarction.
Zhongguo Yao Li Xue Bao. 1999 Jun; 20(6):481-5.ZY

Abstract

AIM

To study the early changes of cardiac angiotensin (Ang) II receptor gene transcription after myocardial infarction (MI) in rats chronically treated with the angiotensin-converting enzyme (ACE) inhibitor ramipril.

METHODS

MI was induced by left anterior descending coronary artery ligation in rats and sham-operated rats were used as control. Rats were treated daily with ramipril (1 mg.kg-1) or water, initiated 1 wk before surgery. Quantitative RT-PCR was applied to determine the Ang II receptors AT1, AT2 receptor gene mRNA levels in the non-infarcted myocardium.

RESULTS

AT1 and AT2 mRNA levels increased time point-dependently in the cardiac septum after MI reaching a peak on d 1. There was no significant difference of the myocardial AT1 and AT2 receptor mRNA levels between the ramipril-treated and water-treated rats after MI.

CONCLUSION

The AT1 and AT2 receptor gene transcription in the non-infarcted myocardium was associated with the process of cardiac remodeling after MI but not affected by ACE inhibition.

Authors+Show Affiliations

Department of Physiology, Shanghai Medical University, China. yczhu@shmu.edu.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10678136

Citation

Zhu, Y C., et al. "Effects of Ramipril On Cardiac Gene Transcription Levels of Angiotensin II Receptors After Myocardial Infarction." Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, vol. 20, no. 6, 1999, pp. 481-5.
Zhu YC, Zhu YZ, Li J, et al. Effects of ramipril on cardiac gene transcription levels of angiotensin II receptors after myocardial infarction. Zhongguo Yao Li Xue Bao. 1999;20(6):481-5.
Zhu, Y. C., Zhu, Y. Z., Li, J., Schäfer, H., Schmidt, W. E., Unger, T., & Yao, T. (1999). Effects of ramipril on cardiac gene transcription levels of angiotensin II receptors after myocardial infarction. Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, 20(6), 481-5.
Zhu YC, et al. Effects of Ramipril On Cardiac Gene Transcription Levels of Angiotensin II Receptors After Myocardial Infarction. Zhongguo Yao Li Xue Bao. 1999;20(6):481-5. PubMed PMID: 10678136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of ramipril on cardiac gene transcription levels of angiotensin II receptors after myocardial infarction. AU - Zhu,Y C, AU - Zhu,Y Z, AU - Li,J, AU - Schäfer,H, AU - Schmidt,W E, AU - Unger,T, AU - Yao,T, PY - 2000/5/8/pubmed PY - 2000/5/8/medline PY - 2000/5/8/entrez SP - 481 EP - 5 JF - Zhongguo yao li xue bao = Acta pharmacologica Sinica JO - Zhongguo Yao Li Xue Bao VL - 20 IS - 6 N2 - AIM: To study the early changes of cardiac angiotensin (Ang) II receptor gene transcription after myocardial infarction (MI) in rats chronically treated with the angiotensin-converting enzyme (ACE) inhibitor ramipril. METHODS: MI was induced by left anterior descending coronary artery ligation in rats and sham-operated rats were used as control. Rats were treated daily with ramipril (1 mg.kg-1) or water, initiated 1 wk before surgery. Quantitative RT-PCR was applied to determine the Ang II receptors AT1, AT2 receptor gene mRNA levels in the non-infarcted myocardium. RESULTS: AT1 and AT2 mRNA levels increased time point-dependently in the cardiac septum after MI reaching a peak on d 1. There was no significant difference of the myocardial AT1 and AT2 receptor mRNA levels between the ramipril-treated and water-treated rats after MI. CONCLUSION: The AT1 and AT2 receptor gene transcription in the non-infarcted myocardium was associated with the process of cardiac remodeling after MI but not affected by ACE inhibition. SN - 0253-9756 UR - https://www.unboundmedicine.com/medline/citation/10678136/Effects_of_ramipril_on_cardiac_gene_transcription_levels_of_angiotensin_II_receptors_after_myocardial_infarction_ L2 - http://www.chinaphar.com/1671-4083/20/481.pdf DB - PRIME DP - Unbound Medicine ER -