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Inhibition of myocardial inward rectifier potassium current by propylbutyldopamine.
Zhongguo Yao Li Xue Bao. 1999 Jun; 20(6):525-8.ZY

Abstract

AIM

To study the effects of propylbutyldopamine (PBDA) on the inward rectifier potassium current (Ik1).

METHODS

The quasi-steady state current-voltage relationship from the isolated guinea pig ventricular cells were measured using whole-cell patch-clamp techniques with a slow ramp depolarization (8 mV.s-1).

RESULTS

PBDA 5, 50, and 100 mumol.L-1 concentration-dependently reduced the inward rectifier potassium current. PBDA blocked Ik1 in guinea pig ventricular cells. The effect of PBDA was not blocked by the selective dopamine D2-receptor blocker, domperidone.

CONCLUSION

PBDA inhibited Ik1 directly, independent of the dopamine D2-receptor.

Authors+Show Affiliations

Department of Physiology, Shanxi Medical University, Taiyuan, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

10678146

Citation

Dun, W, et al. "Inhibition of Myocardial Inward Rectifier Potassium Current By Propylbutyldopamine." Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, vol. 20, no. 6, 1999, pp. 525-8.
Dun W, Zhao RR, Li JG, et al. Inhibition of myocardial inward rectifier potassium current by propylbutyldopamine. Zhongguo Yao Li Xue Bao. 1999;20(6):525-8.
Dun, W., Zhao, R. R., Li, J. G., & Wu, B. W. (1999). Inhibition of myocardial inward rectifier potassium current by propylbutyldopamine. Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica, 20(6), 525-8.
Dun W, et al. Inhibition of Myocardial Inward Rectifier Potassium Current By Propylbutyldopamine. Zhongguo Yao Li Xue Bao. 1999;20(6):525-8. PubMed PMID: 10678146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of myocardial inward rectifier potassium current by propylbutyldopamine. AU - Dun,W, AU - Zhao,R R, AU - Li,J G, AU - Wu,B W, PY - 2000/5/8/pubmed PY - 2000/5/8/medline PY - 2000/5/8/entrez SP - 525 EP - 8 JF - Zhongguo yao li xue bao = Acta pharmacologica Sinica JO - Zhongguo Yao Li Xue Bao VL - 20 IS - 6 N2 - AIM: To study the effects of propylbutyldopamine (PBDA) on the inward rectifier potassium current (Ik1). METHODS: The quasi-steady state current-voltage relationship from the isolated guinea pig ventricular cells were measured using whole-cell patch-clamp techniques with a slow ramp depolarization (8 mV.s-1). RESULTS: PBDA 5, 50, and 100 mumol.L-1 concentration-dependently reduced the inward rectifier potassium current. PBDA blocked Ik1 in guinea pig ventricular cells. The effect of PBDA was not blocked by the selective dopamine D2-receptor blocker, domperidone. CONCLUSION: PBDA inhibited Ik1 directly, independent of the dopamine D2-receptor. SN - 0253-9756 UR - https://www.unboundmedicine.com/medline/citation/10678146/Inhibition_of_myocardial_inward_rectifier_potassium_current_by_propylbutyldopamine_ L2 - http://www.chinaphar.com/1671-4083/20/525.pdf DB - PRIME DP - Unbound Medicine ER -