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Leptin responses to weight loss in postmenopausal women: relationship to sex-hormone binding globulin and visceral obesity.
Obes Res. 2000 Jan; 8(1):29-35.OR

Abstract

OBJECTIVE

Leptin concentrations increase with obesity and tend to decrease with weight loss. However, there is large variation in the response of serum leptin levels to decreases in body weight. This study examines which endocrine and body composition factors are related to changes in leptin concentrations following weight loss in obese, postmenopausal women.

RESEARCH METHODS AND PROCEDURES

Body composition (DXA), visceral obesity (computed tomography), leptin, cortisol, insulin, and sex hormone-binding globulin (SHBG) concentrations were measured in 54 obese (body mass index [BMI] = 32.0+/-4.5 kg/m2; mean +/- SD), women (60+/-6 years) before and after a 6-month hypocaloric diet (250 to 350 kcal/day deficit).

RESULTS

Body weight decreased by 5.8+/-3.4 kg (7.1%) and leptin levels decreased by 6.6+/-11.9 ng/mL (14.5%) after the 6-month treatment. Insulin levels decreased 10% (p< 0.05), but mean SHBG and cortisol levels did not change significantly. Relative changes in leptin with weight loss correlated positively with relative changes in body weight (r = 0.50, p<0.0001), fat mass (r = 0.38, p<0.01), subcutaneous fat area (r = 0.52, p<0.0001), and with baseline values of SHBG (r = 0.38, p<0.01) and baseline intra-abdominal fat area (r = -0.27, p<0.06). Stepwise multiple regression analysis showed that baseline SHBG levels (r2 = 0.24, p<0.01), relative changes in body weight (cumulative r2 = 0.40, p<0.05), and baseline intra-abdominal fat area (cumulative r2 = 0.48, p<0.05) were the only independent predictors of the relative change in leptin, accounting for 48% of the variance.

DISCUSSION

These results suggest that obese, postmenopausal women with a lower initial SHBG and more visceral obesity have a greater decrease in leptin with weight loss, independent of the amount of weight lost.

Authors+Show Affiliations

van Rossum EF
Department of Medicine, University of Maryland School of Medicine, Baltimore VA Medical Center, 21201, USA.
Nicklas BJ
No affiliation info available
Dennis KE
No affiliation info available
Berman DM
No affiliation info available
Goldberg AP
No affiliation info available

MeSH

Body CompositionFemaleHumansHydrocortisoneInsulinLeptinObesityPostmenopauseRegression AnalysisSex Hormone-Binding GlobulinVisceraWeight Loss

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10678256

Citation

van Rossum, E F., et al. "Leptin Responses to Weight Loss in Postmenopausal Women: Relationship to Sex-hormone Binding Globulin and Visceral Obesity." Obesity Research, vol. 8, no. 1, 2000, pp. 29-35.
van Rossum EF, Nicklas BJ, Dennis KE, et al. Leptin responses to weight loss in postmenopausal women: relationship to sex-hormone binding globulin and visceral obesity. Obes Res. 2000;8(1):29-35.
van Rossum, E. F., Nicklas, B. J., Dennis, K. E., Berman, D. M., & Goldberg, A. P. (2000). Leptin responses to weight loss in postmenopausal women: relationship to sex-hormone binding globulin and visceral obesity. Obesity Research, 8(1), 29-35.
van Rossum EF, et al. Leptin Responses to Weight Loss in Postmenopausal Women: Relationship to Sex-hormone Binding Globulin and Visceral Obesity. Obes Res. 2000;8(1):29-35. PubMed PMID: 10678256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leptin responses to weight loss in postmenopausal women: relationship to sex-hormone binding globulin and visceral obesity. AU - van Rossum,E F, AU - Nicklas,B J, AU - Dennis,K E, AU - Berman,D M, AU - Goldberg,A P, PY - 2000/3/11/pubmed PY - 2000/3/11/medline PY - 2000/3/11/entrez SP - 29 EP - 35 JF - Obesity research JO - Obes Res VL - 8 IS - 1 N2 - OBJECTIVE: Leptin concentrations increase with obesity and tend to decrease with weight loss. However, there is large variation in the response of serum leptin levels to decreases in body weight. This study examines which endocrine and body composition factors are related to changes in leptin concentrations following weight loss in obese, postmenopausal women. RESEARCH METHODS AND PROCEDURES: Body composition (DXA), visceral obesity (computed tomography), leptin, cortisol, insulin, and sex hormone-binding globulin (SHBG) concentrations were measured in 54 obese (body mass index [BMI] = 32.0+/-4.5 kg/m2; mean +/- SD), women (60+/-6 years) before and after a 6-month hypocaloric diet (250 to 350 kcal/day deficit). RESULTS: Body weight decreased by 5.8+/-3.4 kg (7.1%) and leptin levels decreased by 6.6+/-11.9 ng/mL (14.5%) after the 6-month treatment. Insulin levels decreased 10% (p< 0.05), but mean SHBG and cortisol levels did not change significantly. Relative changes in leptin with weight loss correlated positively with relative changes in body weight (r = 0.50, p<0.0001), fat mass (r = 0.38, p<0.01), subcutaneous fat area (r = 0.52, p<0.0001), and with baseline values of SHBG (r = 0.38, p<0.01) and baseline intra-abdominal fat area (r = -0.27, p<0.06). Stepwise multiple regression analysis showed that baseline SHBG levels (r2 = 0.24, p<0.01), relative changes in body weight (cumulative r2 = 0.40, p<0.05), and baseline intra-abdominal fat area (cumulative r2 = 0.48, p<0.05) were the only independent predictors of the relative change in leptin, accounting for 48% of the variance. DISCUSSION: These results suggest that obese, postmenopausal women with a lower initial SHBG and more visceral obesity have a greater decrease in leptin with weight loss, independent of the amount of weight lost. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/10678256/Leptin_responses_to_weight_loss_in_postmenopausal_women:_relationship_to_sex_hormone_binding_globulin_and_visceral_obesity_ L2 - https://doi.org/10.1038/oby.2000.5 DB - PRIME DP - Unbound Medicine ER -