Tags

Type your tag names separated by a space and hit enter

Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow-up.

Abstract

BACKGROUND

Numerous components of fruit and vegetables are considered to decrease the risk of gastric carcinoma. In the current prospective study, the authors examined the association between the intake of vitamins, carotenoids, and dietary fiber and vitamin supplement use and the incidence rate of gastric carcinoma.

METHODS

The Netherlands Cohort Study began in 1986 with 120,852 men and women ages 55-69 years. Data regarding diet and other covariates were collected by means of a self-administered questionnaire. After 6.3 years of follow-up, data regarding 282 incident cases of gastric carcinoma and 3123 subcohort members were available for case-cohort analyses.

RESULTS

In analyses adjusted for age, gender, smoking history, education, stomach disorders, and family history of gastric carcinoma, an inverse association with vitamin C intake (relative risk [RR] for highest vs. lowest intake category, 0.7; 95% confidence interval [95% CI], 0.5-1.0) was observed, with a borderline significant trend across three intake categories (P = 0. 06). After the exclusion of cases diagnosed in the first and second follow-up years, the RR was 0.9 (95% CI, 0.6-1.2; P trend = 0.44). Intake of retinol and beta-carotene were associated positively with gastric carcinoma risk with highest versus lowest quintile RRs of 1. 6 (95% CI, 1.0-2.5; P trend = 0.02) and 1.6 (95% CI, 1.0-2.6; P trend = 0.13), respectively, after the exclusion of first-year and second-year cases. Intake of folate, vitamin E, alpha-carotene, lutein plus zeaxanthin, beta-cryptoxanthin, lycopene, and dietary fiber was not associated with gastric carcinoma. Patients who used vitamin A-containing supplements had a lower risk of gastric carcinoma than nonusers (RR = 0.4; 95% CI, 0.2-0.9).

CONCLUSIONS

No clear inverse associations were found between the intake of vitamins, carotenoids, and dietary fiber and the risk of gastric carcinoma after adjustment for confounding variables and the exclusion of first-year and second-year cases.

Links

Authors+Show Affiliations

,

Maastricht University, Department of Epidemiology, Maastricht, The Netherlands.

,

Source

Cancer 88:4 2000 Feb 15 pg 737-48

MeSH

Aged
Anticarcinogenic Agents
Ascorbic Acid
Carotenoids
Cohort Studies
Dietary Fiber
Female
Follow-Up Studies
Humans
Male
Middle Aged
Multivariate Analysis
Netherlands
Prospective Studies
Risk Factors
Stomach Neoplasms
Surveys and Questionnaires
Vitamin A
Vitamin E
Vitamins

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10679641

Citation

Botterweck, A A., et al. "Vitamins, Carotenoids, Dietary Fiber, and the Risk of Gastric Carcinoma: Results From a Prospective Study After 6.3 Years of Follow-up." Cancer, vol. 88, no. 4, 2000, pp. 737-48.
Botterweck AA, van den Brandt PA, Goldbohm RA. Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow-up. Cancer. 2000;88(4):737-48.
Botterweck, A. A., van den Brandt, P. A., & Goldbohm, R. A. (2000). Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow-up. Cancer, 88(4), pp. 737-48.
Botterweck AA, van den Brandt PA, Goldbohm RA. Vitamins, Carotenoids, Dietary Fiber, and the Risk of Gastric Carcinoma: Results From a Prospective Study After 6.3 Years of Follow-up. Cancer. 2000 Feb 15;88(4):737-48. PubMed PMID: 10679641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamins, carotenoids, dietary fiber, and the risk of gastric carcinoma: results from a prospective study after 6.3 years of follow-up. AU - Botterweck,A A, AU - van den Brandt,P A, AU - Goldbohm,R A, PY - 2000/2/19/pubmed PY - 2000/3/11/medline PY - 2000/2/19/entrez SP - 737 EP - 48 JF - Cancer JO - Cancer VL - 88 IS - 4 N2 - BACKGROUND: Numerous components of fruit and vegetables are considered to decrease the risk of gastric carcinoma. In the current prospective study, the authors examined the association between the intake of vitamins, carotenoids, and dietary fiber and vitamin supplement use and the incidence rate of gastric carcinoma. METHODS: The Netherlands Cohort Study began in 1986 with 120,852 men and women ages 55-69 years. Data regarding diet and other covariates were collected by means of a self-administered questionnaire. After 6.3 years of follow-up, data regarding 282 incident cases of gastric carcinoma and 3123 subcohort members were available for case-cohort analyses. RESULTS: In analyses adjusted for age, gender, smoking history, education, stomach disorders, and family history of gastric carcinoma, an inverse association with vitamin C intake (relative risk [RR] for highest vs. lowest intake category, 0.7; 95% confidence interval [95% CI], 0.5-1.0) was observed, with a borderline significant trend across three intake categories (P = 0. 06). After the exclusion of cases diagnosed in the first and second follow-up years, the RR was 0.9 (95% CI, 0.6-1.2; P trend = 0.44). Intake of retinol and beta-carotene were associated positively with gastric carcinoma risk with highest versus lowest quintile RRs of 1. 6 (95% CI, 1.0-2.5; P trend = 0.02) and 1.6 (95% CI, 1.0-2.6; P trend = 0.13), respectively, after the exclusion of first-year and second-year cases. Intake of folate, vitamin E, alpha-carotene, lutein plus zeaxanthin, beta-cryptoxanthin, lycopene, and dietary fiber was not associated with gastric carcinoma. Patients who used vitamin A-containing supplements had a lower risk of gastric carcinoma than nonusers (RR = 0.4; 95% CI, 0.2-0.9). CONCLUSIONS: No clear inverse associations were found between the intake of vitamins, carotenoids, and dietary fiber and the risk of gastric carcinoma after adjustment for confounding variables and the exclusion of first-year and second-year cases. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/10679641/Vitamins_carotenoids_dietary_fiber_and_the_risk_of_gastric_carcinoma:_results_from_a_prospective_study_after_6_3_years_of_follow_up_ L2 - https://medlineplus.gov/dietaryfiber.html DB - PRIME DP - Unbound Medicine ER -