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Lack of effect of dietary chromium supplementation on glucose tolerance, plasma insulin and lipoprotein levels in patients with type 2 diabetes.
Int J Vitam Nutr Res 2000; 70(1):14-8IJ

Abstract

Chromium is essential for the regulation of insulin action, thereby influencing carbohydrate and lipid metabolism. An uncontrolled pilot study was designed to measure the habitual daily intake of chromium in a group of healthy individuals with type 2 diabetes and to monitor the effect of daily supplementation with high chromium yeast on glucose tolerance, plasma insulin and lipoproteins. Twelve free-living adults with type 2 diabetes underwent a glucose tolerance test (GTT) on recruitment, at 4 weeks (after a 7-d duplicate diet collection) and at 12 weeks (following 8 weeks daily supplementation with 100 micrograms of chromium). Urine samples were collected on the day before and the day of each GTT. Blood samples were taken at half hourly intervals for 3 hours during the GTT and the plasma glucose, cholesterol, triglyceride, HDL, LDL and insulin concentration measured. The chromium content of diets and urine samples was determined. Fasting glucose concentrations and glucose area under the curve profiles did not alter significantly post supplementation with the chromium rich yeast. No significant changes in insulin and lipoprotein concentrations were observed. The results of this study do not support the hypothesis that individuals with type 2 diabetes benefit from yeast-based chromium supplements (100 micrograms/day).

Authors+Show Affiliations

Institute of Food Research, Norwich Research Park, Colney, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10683756

Citation

Trow, L G., et al. "Lack of Effect of Dietary Chromium Supplementation On Glucose Tolerance, Plasma Insulin and Lipoprotein Levels in Patients With Type 2 Diabetes." International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition, vol. 70, no. 1, 2000, pp. 14-8.
Trow LG, Lewis J, Greenwood RH, et al. Lack of effect of dietary chromium supplementation on glucose tolerance, plasma insulin and lipoprotein levels in patients with type 2 diabetes. Int J Vitam Nutr Res. 2000;70(1):14-8.
Trow, L. G., Lewis, J., Greenwood, R. H., Sampson, M. J., Self, K. A., Crews, H. M., & Fairweather-Tait, S. J. (2000). Lack of effect of dietary chromium supplementation on glucose tolerance, plasma insulin and lipoprotein levels in patients with type 2 diabetes. International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition, 70(1), pp. 14-8.
Trow LG, et al. Lack of Effect of Dietary Chromium Supplementation On Glucose Tolerance, Plasma Insulin and Lipoprotein Levels in Patients With Type 2 Diabetes. Int J Vitam Nutr Res. 2000;70(1):14-8. PubMed PMID: 10683756.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of effect of dietary chromium supplementation on glucose tolerance, plasma insulin and lipoprotein levels in patients with type 2 diabetes. AU - Trow,L G, AU - Lewis,J, AU - Greenwood,R H, AU - Sampson,M J, AU - Self,K A, AU - Crews,H M, AU - Fairweather-Tait,S J, PY - 2000/2/23/pubmed PY - 2000/3/11/medline PY - 2000/2/23/entrez SP - 14 EP - 8 JF - International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition JO - Int J Vitam Nutr Res VL - 70 IS - 1 N2 - Chromium is essential for the regulation of insulin action, thereby influencing carbohydrate and lipid metabolism. An uncontrolled pilot study was designed to measure the habitual daily intake of chromium in a group of healthy individuals with type 2 diabetes and to monitor the effect of daily supplementation with high chromium yeast on glucose tolerance, plasma insulin and lipoproteins. Twelve free-living adults with type 2 diabetes underwent a glucose tolerance test (GTT) on recruitment, at 4 weeks (after a 7-d duplicate diet collection) and at 12 weeks (following 8 weeks daily supplementation with 100 micrograms of chromium). Urine samples were collected on the day before and the day of each GTT. Blood samples were taken at half hourly intervals for 3 hours during the GTT and the plasma glucose, cholesterol, triglyceride, HDL, LDL and insulin concentration measured. The chromium content of diets and urine samples was determined. Fasting glucose concentrations and glucose area under the curve profiles did not alter significantly post supplementation with the chromium rich yeast. No significant changes in insulin and lipoprotein concentrations were observed. The results of this study do not support the hypothesis that individuals with type 2 diabetes benefit from yeast-based chromium supplements (100 micrograms/day). SN - 0300-9831 UR - https://www.unboundmedicine.com/medline/citation/10683756/Lack_of_effect_of_dietary_chromium_supplementation_on_glucose_tolerance_plasma_insulin_and_lipoprotein_levels_in_patients_with_type_2_diabetes_ L2 - http://econtent.hogrefe.com/doi/full/10.1024/0300-9831.70.1.14?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -