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[The effects of eradication therapy in patients with chronic atrophic gastritis and seropositivity for anti-HP antibodies and histological negativity for Helicobacter pylori].
Clin Ter. 1999 Sep-Oct; 150(5):343-6.CT

Abstract

PURPOSE

The present study was undertaken to analyze both whether the elevated Helicobacter pylori levels in patients with atrophic gastritis without histologic evidence of Helicobacter pylori would be a sign of an ongoing infection and the effects of eradication on gastric atrophy.

PATIENTS AND METHODS

Twenty patients (10 M e 10 F; mean age 57.25 SD 12.19) with atrophic gastritis and elevated Helicobacter pylori titers without histological evidence for Helicobacter-like organisms were included in the study. Ten patients were randomized into eradication group (Group 1) (amoxicillin at 500 mg twice a day for 14 days, metronidazole at 500 mg twice a day for 10 days and omeprazole at 20 mg twice a day for 20 days) and 10 patients were randomized into the control group (Group 2). For all subjects, serum samples and duplicate biopsy specimens (obtained endoscopically) were collected prior the study period and approximately 6 months after the therapy or the follow-up for serum samples and 8 weeks for biopsy specimens.

RESULTS

In the Group 1, the Helicobacter pylori antibody titers dropped significantly in 73.39% of the patients (p < 0.0001), while in the Group 2, the antibody titers declined only in a patient who received antibiotics during the study period (p < 0.00006). In both groups, no significant improvement of atrophic gastritis was observed.

CONCLUSIONS

In conclusion, in patients with atrophic gastritis, the only histological evaluation of Helicobacter-like organisms colonization in gastric biopsy specimens, appeared in our study to underestimate the true prevalence of current HP infection and the importance of the bacterium in the pathogenesis and progression of such disease. Since HP infection is often associated with an increase of proliferative index, the eradication of HP could induce a mucosal protective effect against the other carcinogen factors, although it is extremely unlikely that it can promote the regeneration of a normal gastric mucosa.

Authors+Show Affiliations

Leri O
Dip.to di Malattie Infettive e Tropicali, Università La Sapienza, Roma, Italia. Leri@uniroma1.it
Mastropasqua M
No affiliation info available
Scopelliti G
No affiliation info available
Grasso E
No affiliation info available
Losi T
No affiliation info available
Iadicicco A
No affiliation info available
Perinelli P
No affiliation info available

MeSH

AdultAgedAmoxicillinAnti-Bacterial AgentsAntibodies, BacterialBiopsyDrug Therapy, CombinationFemaleGastric MucosaGastritis, AtrophicHelicobacter InfectionsHelicobacter pyloriHumansMaleMetronidazoleMiddle AgedOmeprazolePenicillinsTime Factors

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

ita

PubMed ID

10687264

Citation

Leri, O, et al. "[The Effects of Eradication Therapy in Patients With Chronic Atrophic Gastritis and Seropositivity for anti-HP Antibodies and Histological Negativity for Helicobacter Pylori]." La Clinica Terapeutica, vol. 150, no. 5, 1999, pp. 343-6.
Leri O, Mastropasqua M, Scopelliti G, et al. [The effects of eradication therapy in patients with chronic atrophic gastritis and seropositivity for anti-HP antibodies and histological negativity for Helicobacter pylori]. Clin Ter. 1999;150(5):343-6.
Leri, O., Mastropasqua, M., Scopelliti, G., Grasso, E., Losi, T., Iadicicco, A., & Perinelli, P. (1999). [The effects of eradication therapy in patients with chronic atrophic gastritis and seropositivity for anti-HP antibodies and histological negativity for Helicobacter pylori]. La Clinica Terapeutica, 150(5), 343-6.
Leri O, et al. [The Effects of Eradication Therapy in Patients With Chronic Atrophic Gastritis and Seropositivity for anti-HP Antibodies and Histological Negativity for Helicobacter Pylori]. Clin Ter. 1999 Sep-Oct;150(5):343-6. PubMed PMID: 10687264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The effects of eradication therapy in patients with chronic atrophic gastritis and seropositivity for anti-HP antibodies and histological negativity for Helicobacter pylori]. AU - Leri,O, AU - Mastropasqua,M, AU - Scopelliti,G, AU - Grasso,E, AU - Losi,T, AU - Iadicicco,A, AU - Perinelli,P, PY - 2000/2/25/pubmed PY - 2000/3/18/medline PY - 2000/2/25/entrez SP - 343 EP - 6 JF - La Clinica terapeutica JO - Clin Ter VL - 150 IS - 5 N2 - PURPOSE: The present study was undertaken to analyze both whether the elevated Helicobacter pylori levels in patients with atrophic gastritis without histologic evidence of Helicobacter pylori would be a sign of an ongoing infection and the effects of eradication on gastric atrophy. PATIENTS AND METHODS: Twenty patients (10 M e 10 F; mean age 57.25 SD 12.19) with atrophic gastritis and elevated Helicobacter pylori titers without histological evidence for Helicobacter-like organisms were included in the study. Ten patients were randomized into eradication group (Group 1) (amoxicillin at 500 mg twice a day for 14 days, metronidazole at 500 mg twice a day for 10 days and omeprazole at 20 mg twice a day for 20 days) and 10 patients were randomized into the control group (Group 2). For all subjects, serum samples and duplicate biopsy specimens (obtained endoscopically) were collected prior the study period and approximately 6 months after the therapy or the follow-up for serum samples and 8 weeks for biopsy specimens. RESULTS: In the Group 1, the Helicobacter pylori antibody titers dropped significantly in 73.39% of the patients (p < 0.0001), while in the Group 2, the antibody titers declined only in a patient who received antibiotics during the study period (p < 0.00006). In both groups, no significant improvement of atrophic gastritis was observed. CONCLUSIONS: In conclusion, in patients with atrophic gastritis, the only histological evaluation of Helicobacter-like organisms colonization in gastric biopsy specimens, appeared in our study to underestimate the true prevalence of current HP infection and the importance of the bacterium in the pathogenesis and progression of such disease. Since HP infection is often associated with an increase of proliferative index, the eradication of HP could induce a mucosal protective effect against the other carcinogen factors, although it is extremely unlikely that it can promote the regeneration of a normal gastric mucosa. SN - 0009-9074 UR - https://www.unboundmedicine.com/medline/citation/10687264/[The_effects_of_eradication_therapy_in_patients_with_chronic_atrophic_gastritis_and_seropositivity_for_anti_HP_antibodies_and_histological_negativity_for_Helicobacter_pylori]_ DB - PRIME DP - Unbound Medicine ER -