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Regulation of extracellular concentrations of 5-hydroxytryptamine (5-HT) in mouse striatum by 5-HT(1A) and 5-HT(1B) receptors.
J Pharmacol Exp Ther. 2000 Mar; 292(3):1111-7.JP

Abstract

The ability of selective serotonin (5-HT) receptor agonists to reduce the extracellular concentration of 5-HT was examined in the striatum of awake, unrestrained mice by in vivo microdialysis. Systemic administration of either 8-OH-PIPAT (R-(+)-trans-8-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)] aminotetralin), a novel 5-HT(1A) receptor agonist, or CP 94,253, a selective 5-HT(1B) receptor agonist, resulted in significant dose-related reductions of striatal 5-HT. The effect of 8-OH-PIPAT (1.0 mg/kg) was blocked by pretreatment with WAY 100635 (0.1 mg/kg), a selective 5-HT(1A) receptor antagonist, but it was not blocked by pretreatment with GR 127935 (0.056 mg/kg), a selective 5-HT(1B/1D) receptor antagonist. The effect of CP 94,253 (1.0 mg/kg) was blocked by pretreatment with GR 127935 (0.056 mg/kg) but was not blocked by pretreatment with WAY 100635 (0.1 mg/kg). Neither WAY 100635 nor GR 127935 altered extracellular 5-HT levels at the doses that were able to completely block the effects of either 8-OH-PIPAT or CP 94,253. The present findings suggest that, on systemic administration, both 8-OH-PIPAT and CP 94,253 are potent and selective agonists at the somatodendritic 5-HT(1A) autoreceptor and terminal 5-HT(1B/1D) autoreceptor, respectively, and are each able to cause decreases in extracellular levels of 5-HT in the mouse striatum by activating a distinct set of receptors.

Authors+Show Affiliations

Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

10688630

Citation

Knobelman, D A., et al. "Regulation of Extracellular Concentrations of 5-hydroxytryptamine (5-HT) in Mouse Striatum By 5-HT(1A) and 5-HT(1B) Receptors." The Journal of Pharmacology and Experimental Therapeutics, vol. 292, no. 3, 2000, pp. 1111-7.
Knobelman DA, Kung HF, Lucki I. Regulation of extracellular concentrations of 5-hydroxytryptamine (5-HT) in mouse striatum by 5-HT(1A) and 5-HT(1B) receptors. J Pharmacol Exp Ther. 2000;292(3):1111-7.
Knobelman, D. A., Kung, H. F., & Lucki, I. (2000). Regulation of extracellular concentrations of 5-hydroxytryptamine (5-HT) in mouse striatum by 5-HT(1A) and 5-HT(1B) receptors. The Journal of Pharmacology and Experimental Therapeutics, 292(3), 1111-7.
Knobelman DA, Kung HF, Lucki I. Regulation of Extracellular Concentrations of 5-hydroxytryptamine (5-HT) in Mouse Striatum By 5-HT(1A) and 5-HT(1B) Receptors. J Pharmacol Exp Ther. 2000;292(3):1111-7. PubMed PMID: 10688630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of extracellular concentrations of 5-hydroxytryptamine (5-HT) in mouse striatum by 5-HT(1A) and 5-HT(1B) receptors. AU - Knobelman,D A, AU - Kung,H F, AU - Lucki,I, PY - 2000/2/25/pubmed PY - 2000/3/25/medline PY - 2000/2/25/entrez SP - 1111 EP - 7 JF - The Journal of pharmacology and experimental therapeutics JO - J Pharmacol Exp Ther VL - 292 IS - 3 N2 - The ability of selective serotonin (5-HT) receptor agonists to reduce the extracellular concentration of 5-HT was examined in the striatum of awake, unrestrained mice by in vivo microdialysis. Systemic administration of either 8-OH-PIPAT (R-(+)-trans-8-hydroxy-2-[N-n-propyl-N-(3'-iodo-2'-propenyl)] aminotetralin), a novel 5-HT(1A) receptor agonist, or CP 94,253, a selective 5-HT(1B) receptor agonist, resulted in significant dose-related reductions of striatal 5-HT. The effect of 8-OH-PIPAT (1.0 mg/kg) was blocked by pretreatment with WAY 100635 (0.1 mg/kg), a selective 5-HT(1A) receptor antagonist, but it was not blocked by pretreatment with GR 127935 (0.056 mg/kg), a selective 5-HT(1B/1D) receptor antagonist. The effect of CP 94,253 (1.0 mg/kg) was blocked by pretreatment with GR 127935 (0.056 mg/kg) but was not blocked by pretreatment with WAY 100635 (0.1 mg/kg). Neither WAY 100635 nor GR 127935 altered extracellular 5-HT levels at the doses that were able to completely block the effects of either 8-OH-PIPAT or CP 94,253. The present findings suggest that, on systemic administration, both 8-OH-PIPAT and CP 94,253 are potent and selective agonists at the somatodendritic 5-HT(1A) autoreceptor and terminal 5-HT(1B/1D) autoreceptor, respectively, and are each able to cause decreases in extracellular levels of 5-HT in the mouse striatum by activating a distinct set of receptors. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/10688630/Regulation_of_extracellular_concentrations_of_5_hydroxytryptamine__5_HT__in_mouse_striatum_by_5_HT_1A__and_5_HT_1B__receptors_ L2 - https://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=10688630 DB - PRIME DP - Unbound Medicine ER -