Tags

Type your tag names separated by a space and hit enter

Minimal stimulation IVF using clomiphene citrate and oral contraceptive pill pretreatment for LH suppression.
Fertil Steril. 2000 Mar; 73(3):587-90.FS

Abstract

OBJECTIVE

To determine if oral contraceptive pill (OC) pre-treatment prior to minimal stimulation IVF using clomiphene citrate (CC) would make the procedure easier to perform by preventing the LH surge and result in pregnancy rates (PRs) comparable to stimulated IVF.

DESIGN

Prospective cohort study.

SETTING

Private tertiary infertility center.

PATIENT(S)

Thirty-two women with tubal or pelvic adhesive disease as the cause of their infertility, ovulatory cycles, under the age of 40, and no male factor.

INTERVENTION(S)

Two-month ovarian-hypothalamic-pituitary axis suppression with OC followed by CC 100 mg on day 3 of the cycle for 8 days, hCG administration midcycle, follicle aspiration, IVF, and embryo transfer.

MAIN OUTCOME MEASURE(S)

Oocytes retrieved, serum LH and estradiol levels, maturity of oocytes, fertilization rates, embryo number and quality, and PRs.

RESULT(S)

Thirty-six patients completed 71 stimulation cycles and 64 follicle aspirations. No LH surges occurred with a mean mature oocytes retrieved of 3.2, 90% fertilization rate, and mean 2.5 embryos transferred. Twenty-one of the 64 cycles resulted in a clinical pregnancy (32.8% PR per retrieval) with 2 other biochemical pregnancies and 3 twin gestations. This was not significantly different from the matched cohort stimulated IVF.

CONCLUSION(S)

Minimal stimulation IVF is a simple, low-cost, and low-risk alternative to stimulated IVF with comparable PRs.

Authors+Show Affiliations

Bellingham IVF and Infertility Center, Bellingham, Washington, USA.No affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

10689017

Citation

Branigan, E F., and M A. Estes. "Minimal Stimulation IVF Using Clomiphene Citrate and Oral Contraceptive Pill Pretreatment for LH Suppression." Fertility and Sterility, vol. 73, no. 3, 2000, pp. 587-90.
Branigan EF, Estes MA. Minimal stimulation IVF using clomiphene citrate and oral contraceptive pill pretreatment for LH suppression. Fertil Steril. 2000;73(3):587-90.
Branigan, E. F., & Estes, M. A. (2000). Minimal stimulation IVF using clomiphene citrate and oral contraceptive pill pretreatment for LH suppression. Fertility and Sterility, 73(3), 587-90.
Branigan EF, Estes MA. Minimal Stimulation IVF Using Clomiphene Citrate and Oral Contraceptive Pill Pretreatment for LH Suppression. Fertil Steril. 2000;73(3):587-90. PubMed PMID: 10689017.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Minimal stimulation IVF using clomiphene citrate and oral contraceptive pill pretreatment for LH suppression. AU - Branigan,E F, AU - Estes,M A, PY - 2000/2/26/pubmed PY - 2000/3/25/medline PY - 2000/2/26/entrez KW - Americas KW - Biology KW - Clinical Research KW - Clomiphene KW - Contraception KW - Contraceptive Methods KW - Developed Countries KW - Endocrine System KW - Family Planning KW - Fertility Agents KW - Fertilization KW - Gonadotropins KW - Gonadotropins, Pituitary KW - Hormones KW - In Vitro KW - Luteinizing Hormone KW - North America KW - Northern America KW - Oral Contraceptives KW - Physiology KW - Reproduction KW - Reproductive Control Agents KW - Reproductive Technologies KW - Research Methodology KW - Research Report KW - United States SP - 587 EP - 90 JF - Fertility and sterility JO - Fertil Steril VL - 73 IS - 3 N2 - OBJECTIVE: To determine if oral contraceptive pill (OC) pre-treatment prior to minimal stimulation IVF using clomiphene citrate (CC) would make the procedure easier to perform by preventing the LH surge and result in pregnancy rates (PRs) comparable to stimulated IVF. DESIGN: Prospective cohort study. SETTING: Private tertiary infertility center. PATIENT(S): Thirty-two women with tubal or pelvic adhesive disease as the cause of their infertility, ovulatory cycles, under the age of 40, and no male factor. INTERVENTION(S): Two-month ovarian-hypothalamic-pituitary axis suppression with OC followed by CC 100 mg on day 3 of the cycle for 8 days, hCG administration midcycle, follicle aspiration, IVF, and embryo transfer. MAIN OUTCOME MEASURE(S): Oocytes retrieved, serum LH and estradiol levels, maturity of oocytes, fertilization rates, embryo number and quality, and PRs. RESULT(S): Thirty-six patients completed 71 stimulation cycles and 64 follicle aspirations. No LH surges occurred with a mean mature oocytes retrieved of 3.2, 90% fertilization rate, and mean 2.5 embryos transferred. Twenty-one of the 64 cycles resulted in a clinical pregnancy (32.8% PR per retrieval) with 2 other biochemical pregnancies and 3 twin gestations. This was not significantly different from the matched cohort stimulated IVF. CONCLUSION(S): Minimal stimulation IVF is a simple, low-cost, and low-risk alternative to stimulated IVF with comparable PRs. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/10689017/Minimal_stimulation_IVF_using_clomiphene_citrate_and_oral_contraceptive_pill_pretreatment_for_LH_suppression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(99)00584-1 DB - PRIME DP - Unbound Medicine ER -