Tags

Type your tag names separated by a space and hit enter

Clinical relevance of food additives in adult patients with atopic dermatitis.
Clin Exp Allergy. 2000 Mar; 30(3):407-14.CE

Abstract

BACKGROUND

Adverse reactions to food play an important role in the pathogenesis of atopic dermatitis (AD). In infancy and childhood, food allergies are observed in up to 30%, whereas nonallergic hypersensitivity reactions (pseudoallergic reactions) towards food additives have been reported to occur between 2 and 7%. By contrast, sensitizations towards food allergens are rarely of clinical relevance in adults and little data is available on nonallergic hypersensitivity reactions. To date the role of pseudoallergic reactions as an aggravating factor in AD of adult patients remains controversial. However, many adult patients report on food-related aggravation of the disease and nonallergic hypersensitivity reactions have been incriminated repeatedly.

OBJECTIVE

To elucidate the relevance of food additives in adult patients suffering from AD.

METHODS

Fifty patients were monitored over 4 weeks under regular diet followed by 6 weeks of a diet omitting known pseudoallergens. Skin status of patients was assessed every 2 weeks by a standardized scoring, and serum eosinophilic cationic protein (ECP) was determined before and after diet.

RESULTS

Nine of fifty patients dropped out, 26 showed a significant improvement of the Costa-score by 57%. In 23/26 patients a corresponding reduction of serum ECP level by 52% on average was determined. Responder patients (24/26) were orally challenged with food rich in pseudoallergens followed by double-blind exposure to food additives (n = 15). A worsening of the eczema was seen in 19/24 patients after intake of pseudoallergen-rich food and in 6/15 patients after exposure to food additives.

CONCLUSION

These results indicate that a subgroup of adult patients with AD clinically improve on low-pseudoallergen diet but only a small subgroup respond to oral provocation with food additives.

Authors+Show Affiliations

Department of Dermatology and Allergy, Charité Clinic, Humboldt University, Berlin, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

10691900

Citation

Worm, M, et al. "Clinical Relevance of Food Additives in Adult Patients With Atopic Dermatitis." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 30, no. 3, 2000, pp. 407-14.
Worm M, Ehlers I, Sterry W, et al. Clinical relevance of food additives in adult patients with atopic dermatitis. Clin Exp Allergy. 2000;30(3):407-14.
Worm, M., Ehlers, I., Sterry, W., & Zuberbier, T. (2000). Clinical relevance of food additives in adult patients with atopic dermatitis. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 30(3), 407-14.
Worm M, et al. Clinical Relevance of Food Additives in Adult Patients With Atopic Dermatitis. Clin Exp Allergy. 2000;30(3):407-14. PubMed PMID: 10691900.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical relevance of food additives in adult patients with atopic dermatitis. AU - Worm,M, AU - Ehlers,I, AU - Sterry,W, AU - Zuberbier,T, PY - 2000/2/26/pubmed PY - 2000/5/16/medline PY - 2000/2/26/entrez SP - 407 EP - 14 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 30 IS - 3 N2 - BACKGROUND: Adverse reactions to food play an important role in the pathogenesis of atopic dermatitis (AD). In infancy and childhood, food allergies are observed in up to 30%, whereas nonallergic hypersensitivity reactions (pseudoallergic reactions) towards food additives have been reported to occur between 2 and 7%. By contrast, sensitizations towards food allergens are rarely of clinical relevance in adults and little data is available on nonallergic hypersensitivity reactions. To date the role of pseudoallergic reactions as an aggravating factor in AD of adult patients remains controversial. However, many adult patients report on food-related aggravation of the disease and nonallergic hypersensitivity reactions have been incriminated repeatedly. OBJECTIVE: To elucidate the relevance of food additives in adult patients suffering from AD. METHODS: Fifty patients were monitored over 4 weeks under regular diet followed by 6 weeks of a diet omitting known pseudoallergens. Skin status of patients was assessed every 2 weeks by a standardized scoring, and serum eosinophilic cationic protein (ECP) was determined before and after diet. RESULTS: Nine of fifty patients dropped out, 26 showed a significant improvement of the Costa-score by 57%. In 23/26 patients a corresponding reduction of serum ECP level by 52% on average was determined. Responder patients (24/26) were orally challenged with food rich in pseudoallergens followed by double-blind exposure to food additives (n = 15). A worsening of the eczema was seen in 19/24 patients after intake of pseudoallergen-rich food and in 6/15 patients after exposure to food additives. CONCLUSION: These results indicate that a subgroup of adult patients with AD clinically improve on low-pseudoallergen diet but only a small subgroup respond to oral provocation with food additives. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/10691900/Clinical_relevance_of_food_additives_in_adult_patients_with_atopic_dermatitis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-7894&date=2000&volume=30&issue=3&spage=407 DB - PRIME DP - Unbound Medicine ER -