Tags

Type your tag names separated by a space and hit enter

Vegetables, fruits, and related nutrients and risk of breast cancer: a case-control study in Uruguay.
Nutr Cancer 1999; 35(2):111-9NC

Abstract

To evaluate whether the protective effect associated with vegetables and fruits in breast cancer could be explained by nutrients and bioactive substances present in these plant foods, we carried out a case-control study in Uruguay including 400 cases and 405 controls. The intake of vegetables, fruits, and related nutrients was estimated with a food frequency questionnaire on 64 food items. This questionnaire allowed the calculation of total energy intake, and nutrients were calorie adjusted by the residuals method. Odds ratios for study variables were estimated by unconditional multiple logistic regression. Total vegetable, total fruit, dietary fiber, vitamin C, vitamin E, lycopene, folate, and total phytosterol intakes were inversely associated with breast cancer risk [4th quartile odds ratio for total vegetable intake = 0.41, 95% confidence interval = 0.26-0.65, p (for trend) = 0.004]. The association with total vegetable intake was not independent of lycopene intake. The results related to vegetable and nutrient intakes are consistent with antioxidant and antiestrogenic effects. This could be mediated, among other nutrients, by dietary fiber and lycopene intake. The role of other unmeasured phytochemicals, correlated with dietary fiber and lycopene intakes, cannot be ruled out.

Authors+Show Affiliations

Registro Nacional de Cáncer, Montevideo, Uruguay.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10693163

Citation

Ronco, A, et al. "Vegetables, Fruits, and Related Nutrients and Risk of Breast Cancer: a Case-control Study in Uruguay." Nutrition and Cancer, vol. 35, no. 2, 1999, pp. 111-9.
Ronco A, De Stefani E, Boffetta P, et al. Vegetables, fruits, and related nutrients and risk of breast cancer: a case-control study in Uruguay. Nutr Cancer. 1999;35(2):111-9.
Ronco, A., De Stefani, E., Boffetta, P., Deneo-Pellegrini, H., Mendilaharsu, M., & Leborgne, F. (1999). Vegetables, fruits, and related nutrients and risk of breast cancer: a case-control study in Uruguay. Nutrition and Cancer, 35(2), pp. 111-9.
Ronco A, et al. Vegetables, Fruits, and Related Nutrients and Risk of Breast Cancer: a Case-control Study in Uruguay. Nutr Cancer. 1999;35(2):111-9. PubMed PMID: 10693163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vegetables, fruits, and related nutrients and risk of breast cancer: a case-control study in Uruguay. AU - Ronco,A, AU - De Stefani,E, AU - Boffetta,P, AU - Deneo-Pellegrini,H, AU - Mendilaharsu,M, AU - Leborgne,F, PY - 2000/2/29/pubmed PY - 2000/3/11/medline PY - 2000/2/29/entrez SP - 111 EP - 9 JF - Nutrition and cancer JO - Nutr Cancer VL - 35 IS - 2 N2 - To evaluate whether the protective effect associated with vegetables and fruits in breast cancer could be explained by nutrients and bioactive substances present in these plant foods, we carried out a case-control study in Uruguay including 400 cases and 405 controls. The intake of vegetables, fruits, and related nutrients was estimated with a food frequency questionnaire on 64 food items. This questionnaire allowed the calculation of total energy intake, and nutrients were calorie adjusted by the residuals method. Odds ratios for study variables were estimated by unconditional multiple logistic regression. Total vegetable, total fruit, dietary fiber, vitamin C, vitamin E, lycopene, folate, and total phytosterol intakes were inversely associated with breast cancer risk [4th quartile odds ratio for total vegetable intake = 0.41, 95% confidence interval = 0.26-0.65, p (for trend) = 0.004]. The association with total vegetable intake was not independent of lycopene intake. The results related to vegetable and nutrient intakes are consistent with antioxidant and antiestrogenic effects. This could be mediated, among other nutrients, by dietary fiber and lycopene intake. The role of other unmeasured phytochemicals, correlated with dietary fiber and lycopene intakes, cannot be ruled out. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/10693163/Vegetables_fruits_and_related_nutrients_and_risk_of_breast_cancer:_a_case_control_study_in_Uruguay_ L2 - http://www.tandfonline.com/doi/full/10.1207/S15327914NC352_3 DB - PRIME DP - Unbound Medicine ER -