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Comparison of an oleic acid enriched-diet vs NCEP-I diet on LDL susceptibility to oxidative modifications.
Eur J Clin Nutr. 2000 Jan; 54(1):61-7.EJ

Abstract

OBJECTIVE

The objective of this trial was to compare the effect on the susceptibility of plasma Low Density Lipoprotein (LDL) to oxidative modifications of consumption of two oleic rich diets, prepared with two different plant oils, virgin olive oil (OL)1 and refined high monounsaturated fatty acids (MUFA sunflower oil (SU)), with the susceptibility of plasma LDL to oxidation after an National Cholesterol Education Program step 1 (NCEP-I) phase diet.

DESIGN

A randomized crossover design.

SUBJECTS AND INTERVENTIONS

Twenty-two healthy normolipidemic young males consumed an NCEP-I diet for a 4-week period. Subjects were then assigned to two diets each of 4-weeks duration. Group one was placed on an olive oil enriched diet (40% fat, 22% MUFA) followed by a 4-week period of a MUFA diet enriched in sunflower oil (40% fat, 22% MUFA). In group two, the order of the diets was reversed.

RESULTS

Both MUFA diets induced a decrease in saturated (14:0, 16:0, and 18:0) and an increase in monounsaturated and polyunsaturated n-6 (18:2, 20:3, and 20:5) plasma LDL-phospholipid fatty acids, compared to the NCEP-I diet (P<0.01). No significant differences in lag times were observed between the olive oil and the NCEP-I diet periods. However there was a greater inhibition time (P<0.001) when subjects consumed the MUFA rich sunflower oil diet compared to the NCEP-I diet. These differences were probably related to the relative enrichment of plasma LDL particles in alpha-tocopherol due to the high vitamin E content of the MUFA-rich sunflower oil. Indeed, the alpha-tocopherol content was positively correlated with lag time (r=0.338; P<0.008).

CONCLUSION

Our findings suggest that changes in plasma LDL alpha-tocopherol content with practical solid-food diets can decrease its susceptibility to oxidation.

SPONSORSHIP

This work has been supported by grants from the Investigaciones de la Seguridad Social (FIS 92/0182, to Francisco Pérez Jiménez); and from Koype Co, Andújar, Jaén, Spain. European Journal of Clinical Nutrition (2000) 54, 61-67

Authors+Show Affiliations

Lipids Research Unit, Hospital University Reina Sofia, Medical School, University of Córdoba, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

10694774

Citation

Castro, P, et al. "Comparison of an Oleic Acid Enriched-diet Vs NCEP-I Diet On LDL Susceptibility to Oxidative Modifications." European Journal of Clinical Nutrition, vol. 54, no. 1, 2000, pp. 61-7.
Castro P, Miranda JL, Gómez P, et al. Comparison of an oleic acid enriched-diet vs NCEP-I diet on LDL susceptibility to oxidative modifications. Eur J Clin Nutr. 2000;54(1):61-7.
Castro, P., Miranda, J. L., Gómez, P., Escalante, D. M., Segura, F. L., Martín, A., Fuentes, F., Blanco, A., Ordovás, J. M., & Jiménez, F. P. (2000). Comparison of an oleic acid enriched-diet vs NCEP-I diet on LDL susceptibility to oxidative modifications. European Journal of Clinical Nutrition, 54(1), 61-7.
Castro P, et al. Comparison of an Oleic Acid Enriched-diet Vs NCEP-I Diet On LDL Susceptibility to Oxidative Modifications. Eur J Clin Nutr. 2000;54(1):61-7. PubMed PMID: 10694774.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of an oleic acid enriched-diet vs NCEP-I diet on LDL susceptibility to oxidative modifications. AU - Castro,P, AU - Miranda,J L, AU - Gómez,P, AU - Escalante,D M, AU - Segura,F L, AU - Martín,A, AU - Fuentes,F, AU - Blanco,A, AU - Ordovás,J M, AU - Jiménez,F P, PY - 2000/3/1/pubmed PY - 2000/3/25/medline PY - 2000/3/1/entrez SP - 61 EP - 7 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 54 IS - 1 N2 - OBJECTIVE: The objective of this trial was to compare the effect on the susceptibility of plasma Low Density Lipoprotein (LDL) to oxidative modifications of consumption of two oleic rich diets, prepared with two different plant oils, virgin olive oil (OL)1 and refined high monounsaturated fatty acids (MUFA sunflower oil (SU)), with the susceptibility of plasma LDL to oxidation after an National Cholesterol Education Program step 1 (NCEP-I) phase diet. DESIGN: A randomized crossover design. SUBJECTS AND INTERVENTIONS: Twenty-two healthy normolipidemic young males consumed an NCEP-I diet for a 4-week period. Subjects were then assigned to two diets each of 4-weeks duration. Group one was placed on an olive oil enriched diet (40% fat, 22% MUFA) followed by a 4-week period of a MUFA diet enriched in sunflower oil (40% fat, 22% MUFA). In group two, the order of the diets was reversed. RESULTS: Both MUFA diets induced a decrease in saturated (14:0, 16:0, and 18:0) and an increase in monounsaturated and polyunsaturated n-6 (18:2, 20:3, and 20:5) plasma LDL-phospholipid fatty acids, compared to the NCEP-I diet (P<0.01). No significant differences in lag times were observed between the olive oil and the NCEP-I diet periods. However there was a greater inhibition time (P<0.001) when subjects consumed the MUFA rich sunflower oil diet compared to the NCEP-I diet. These differences were probably related to the relative enrichment of plasma LDL particles in alpha-tocopherol due to the high vitamin E content of the MUFA-rich sunflower oil. Indeed, the alpha-tocopherol content was positively correlated with lag time (r=0.338; P<0.008). CONCLUSION: Our findings suggest that changes in plasma LDL alpha-tocopherol content with practical solid-food diets can decrease its susceptibility to oxidation. SPONSORSHIP: This work has been supported by grants from the Investigaciones de la Seguridad Social (FIS 92/0182, to Francisco Pérez Jiménez); and from Koype Co, Andújar, Jaén, Spain. European Journal of Clinical Nutrition (2000) 54, 61-67 SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/10694774/Comparison_of_an_oleic_acid_enriched_diet_vs_NCEP_I_diet_on_LDL_susceptibility_to_oxidative_modifications_ L2 - https://doi.org/10.1038/sj.ejcn.1600894 DB - PRIME DP - Unbound Medicine ER -