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Toenail selenium and breast cancer-a case-control study in Finland.

Abstract

OBJECTIVE

Low levels of selenium have been associated with a higher risk of cardiovascular diseases and cancer in humans. Since 1984, selenium supplementation through fertilizers has been employed in Finland to increase the very low concentration of selenium in the nation's food supply. As a result, the selenium concentration of Finnish foods became one of the highest in Europe. A decade after selenium supplementation began, the association between toenail selenium and the risk of breast cancer was examined.

DESIGN

Case-control study.

SETTING

Eastern Finland.

SUBJECTS

289 pre- and postmenopausal breast cancer cases and 433 community controls. The diagnosis was unknown at the time the toenail samples were collected.

RESULTS

The mean toenail selenium concentration was 0.80 mg/kg in premenopausal cases and 0.84 mg/kg in premenopausal controls: and 0. 77 mg/kg in postmenopausal cases and 0.80 mg/kg in postmenopausal controls. The odds ratio (OR) comparing the highest with the lowest quintiles of toenail selenium concentration was 1.1 (95% CI 0.4-3.2) in premenopausal women and 0.7 (95% CI 0.3-1.5) in postmenopausal women. The intake of retinol, beta-carotene, vitamin E and vitamin C did not change the association between toenail selenium and breast cancer.

CONCLUSIONS

A decade after selenium supplementation, selenium seems not to be an important factor in the etiology of breast cancer, neither in premenopausal nor postmenopausal women.

SPONSORSHIP

This work was supported by the EVO funds from the Kuopio University Hospital and by research grants from the Academy of Finland, Yrjö Jahnsson Foundation and Juho Vainio Foundation. European Journal of Clinical Nutrition (2000) 54, 98-103

Links

Authors+Show Affiliations

,

National Public Health Institute, Department of Nutrition, Mannerheimintie 166, Helsinki, Finland.

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Source

MeSH

Adult
Aged
Aging
Ascorbic Acid
Breast Neoplasms
Case-Control Studies
Female
Finland
Humans
Middle Aged
Nails
Odds Ratio
Postmenopause
Premenopause
Risk Factors
Selenium
Vitamin A
Vitamin E
beta Carotene

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10694779

Citation

Männistö, S, et al. "Toenail Selenium and Breast Cancer-a Case-control Study in Finland." European Journal of Clinical Nutrition, vol. 54, no. 2, 2000, pp. 98-103.
Männistö S, Alfthan G, Virtanen M, et al. Toenail selenium and breast cancer-a case-control study in Finland. Eur J Clin Nutr. 2000;54(2):98-103.
Männistö, S., Alfthan, G., Virtanen, M., Kataja, V., Uusitupa, M., & Pietinen, P. (2000). Toenail selenium and breast cancer-a case-control study in Finland. European Journal of Clinical Nutrition, 54(2), pp. 98-103.
Männistö S, et al. Toenail Selenium and Breast Cancer-a Case-control Study in Finland. Eur J Clin Nutr. 2000;54(2):98-103. PubMed PMID: 10694779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toenail selenium and breast cancer-a case-control study in Finland. AU - Männistö,S, AU - Alfthan,G, AU - Virtanen,M, AU - Kataja,V, AU - Uusitupa,M, AU - Pietinen,P, PY - 2000/3/1/pubmed PY - 2000/3/1/medline PY - 2000/3/1/entrez SP - 98 EP - 103 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 54 IS - 2 N2 - OBJECTIVE: Low levels of selenium have been associated with a higher risk of cardiovascular diseases and cancer in humans. Since 1984, selenium supplementation through fertilizers has been employed in Finland to increase the very low concentration of selenium in the nation's food supply. As a result, the selenium concentration of Finnish foods became one of the highest in Europe. A decade after selenium supplementation began, the association between toenail selenium and the risk of breast cancer was examined. DESIGN: Case-control study. SETTING: Eastern Finland. SUBJECTS: 289 pre- and postmenopausal breast cancer cases and 433 community controls. The diagnosis was unknown at the time the toenail samples were collected. RESULTS: The mean toenail selenium concentration was 0.80 mg/kg in premenopausal cases and 0.84 mg/kg in premenopausal controls: and 0. 77 mg/kg in postmenopausal cases and 0.80 mg/kg in postmenopausal controls. The odds ratio (OR) comparing the highest with the lowest quintiles of toenail selenium concentration was 1.1 (95% CI 0.4-3.2) in premenopausal women and 0.7 (95% CI 0.3-1.5) in postmenopausal women. The intake of retinol, beta-carotene, vitamin E and vitamin C did not change the association between toenail selenium and breast cancer. CONCLUSIONS: A decade after selenium supplementation, selenium seems not to be an important factor in the etiology of breast cancer, neither in premenopausal nor postmenopausal women. SPONSORSHIP: This work was supported by the EVO funds from the Kuopio University Hospital and by research grants from the Academy of Finland, Yrjö Jahnsson Foundation and Juho Vainio Foundation. European Journal of Clinical Nutrition (2000) 54, 98-103 SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/10694779/Toenail_selenium_and_breast_cancer_a_case_control_study_in_Finland_ L2 - http://www.diseaseinfosearch.org/result/960 DB - PRIME DP - Unbound Medicine ER -