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Prevention and treatment of chemotherapy- and radiotherapy-induced oral mucositis: a review.
Oral Oncol 1999; 35(5):453-70OO

Abstract

Oral mucositis is a distressing toxic effect of systemic chemotherapy with many commonly utilized drugs and of head and neck irradiation in patients with cancer. The agents and methods that have been used and studied in chemotherapy- and radiotherapy-induced oral mucositis, their mechanisms of action, and the current knowledge of their efficiency to reduce the incidence, severity or shorten the duration of oral mucositis are reviewed in this article. Oral cooling is a cheap and available method to lower the severity of bolus 5-fluorouracil-induced oral mucositis. However, more effective methods are needed. Results of studies with granulocyte-macrophage colony-stimulating factor or granulocyte colony-stimulating factor are promising. Lasers are partly beneficial, but equipment-demanding. Modification of the chemotherapy regimen resulting in shortening of the exposition time to chemotherapy agents or chronomodulation of chemotherapy has been shown to lower mucosal toxicity of some regimens. Results of animal studies with locally applied transforming growth factor beta 3 and interleukin-11 are also promising. Based on the findings of the role of the inflammatory cascade in the response of normal tissues to chemotherapy and radiotherapy, anti-inflammatory drugs might be beneficial. At the present time, no agent has been shown to be uniformly efficacious and can be accepted as standard therapy of chemotherapy- and radiotherapy-induced oral mucositis. Further intensive research is needed.

Authors+Show Affiliations

Department of Radiotherapy, University Hospital of Ostrava, Ostrava-Poruba, Czeck Republic. pavlina.plevova@fnspo.cz

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

10694945

Citation

Plevová, P. "Prevention and Treatment of Chemotherapy- and Radiotherapy-induced Oral Mucositis: a Review." Oral Oncology, vol. 35, no. 5, 1999, pp. 453-70.
Plevová P. Prevention and treatment of chemotherapy- and radiotherapy-induced oral mucositis: a review. Oral Oncol. 1999;35(5):453-70.
Plevová, P. (1999). Prevention and treatment of chemotherapy- and radiotherapy-induced oral mucositis: a review. Oral Oncology, 35(5), pp. 453-70.
Plevová P. Prevention and Treatment of Chemotherapy- and Radiotherapy-induced Oral Mucositis: a Review. Oral Oncol. 1999;35(5):453-70. PubMed PMID: 10694945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention and treatment of chemotherapy- and radiotherapy-induced oral mucositis: a review. A1 - Plevová,P, PY - 2000/3/1/pubmed PY - 2000/3/18/medline PY - 2000/3/1/entrez SP - 453 EP - 70 JF - Oral oncology JO - Oral Oncol. VL - 35 IS - 5 N2 - Oral mucositis is a distressing toxic effect of systemic chemotherapy with many commonly utilized drugs and of head and neck irradiation in patients with cancer. The agents and methods that have been used and studied in chemotherapy- and radiotherapy-induced oral mucositis, their mechanisms of action, and the current knowledge of their efficiency to reduce the incidence, severity or shorten the duration of oral mucositis are reviewed in this article. Oral cooling is a cheap and available method to lower the severity of bolus 5-fluorouracil-induced oral mucositis. However, more effective methods are needed. Results of studies with granulocyte-macrophage colony-stimulating factor or granulocyte colony-stimulating factor are promising. Lasers are partly beneficial, but equipment-demanding. Modification of the chemotherapy regimen resulting in shortening of the exposition time to chemotherapy agents or chronomodulation of chemotherapy has been shown to lower mucosal toxicity of some regimens. Results of animal studies with locally applied transforming growth factor beta 3 and interleukin-11 are also promising. Based on the findings of the role of the inflammatory cascade in the response of normal tissues to chemotherapy and radiotherapy, anti-inflammatory drugs might be beneficial. At the present time, no agent has been shown to be uniformly efficacious and can be accepted as standard therapy of chemotherapy- and radiotherapy-induced oral mucositis. Further intensive research is needed. SN - 1368-8375 UR - https://www.unboundmedicine.com/medline/citation/10694945/Prevention_and_treatment_of_chemotherapy__and_radiotherapy_induced_oral_mucositis:_a_review_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1368-8375(99)00033-0 DB - PRIME DP - Unbound Medicine ER -