Tags

Type your tag names separated by a space and hit enter

Double blind controlled trial of effect of cisapride on gastric emptying in diabetics.
Trop Gastroenterol. 1999 Jul-Sep; 20(3):116-9.TG

Abstract

AIMS

Diabetic gastroparesis is a common complication seen in 20-50% of patients due to autonomic neuropathy involving vagal supply. Cisapride, a specific gastrointestinal cholinomimetic agent may thus be effective.

METHODS

Fifty-one diabetic patients (age 12-65 years) of disease duration > 5 years were assessed for symptomatic gastroparesis, other diabetic complications and glycemic control. Gastric emptying time (GET) was estimated using a solid meal method (99mTc labeled rice based idli) and patients randomized to receive either cisapride or placebo for a period of 2 weeks. Cisapride was administered in a dose of 10 mg TID. GET and symptom scores were reassessed on the therapy after 2 weeks.

RESULTS

Twenty nine of 51 (56.8%) patients had gastroparesis. Mean GET in the gastroparesis group was 141 +/- 66 minutes compared to 24.53 +/- 10 minutes in the non gastroparesis group (p < 0.01). GET decreased by 72% amongst the patients who received cisapride compared to 23% in the placebo group (p < 0.001). Symptom scores also improved in the cisapride group; no adverse effects were noted.

CONCLUSIONS

Cisapride improves the symptom score and the solid gastric emptying time in patients suffering from diabetic gastroparesis.

Authors+Show Affiliations

All India Institute of Medical Sciences, New Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

10695417

Citation

Dutta, U, et al. "Double Blind Controlled Trial of Effect of Cisapride On Gastric Emptying in Diabetics." Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation, vol. 20, no. 3, 1999, pp. 116-9.
Dutta U, Padhy AK, Ahuja V, et al. Double blind controlled trial of effect of cisapride on gastric emptying in diabetics. Trop Gastroenterol. 1999;20(3):116-9.
Dutta, U., Padhy, A. K., Ahuja, V., & Sharma, M. P. (1999). Double blind controlled trial of effect of cisapride on gastric emptying in diabetics. Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation, 20(3), 116-9.
Dutta U, et al. Double Blind Controlled Trial of Effect of Cisapride On Gastric Emptying in Diabetics. Trop Gastroenterol. 1999 Jul-Sep;20(3):116-9. PubMed PMID: 10695417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Double blind controlled trial of effect of cisapride on gastric emptying in diabetics. AU - Dutta,U, AU - Padhy,A K, AU - Ahuja,V, AU - Sharma,M P, PY - 2000/3/1/pubmed PY - 2000/3/18/medline PY - 2000/3/1/entrez SP - 116 EP - 9 JF - Tropical gastroenterology : official journal of the Digestive Diseases Foundation JO - Trop Gastroenterol VL - 20 IS - 3 N2 - AIMS: Diabetic gastroparesis is a common complication seen in 20-50% of patients due to autonomic neuropathy involving vagal supply. Cisapride, a specific gastrointestinal cholinomimetic agent may thus be effective. METHODS: Fifty-one diabetic patients (age 12-65 years) of disease duration > 5 years were assessed for symptomatic gastroparesis, other diabetic complications and glycemic control. Gastric emptying time (GET) was estimated using a solid meal method (99mTc labeled rice based idli) and patients randomized to receive either cisapride or placebo for a period of 2 weeks. Cisapride was administered in a dose of 10 mg TID. GET and symptom scores were reassessed on the therapy after 2 weeks. RESULTS: Twenty nine of 51 (56.8%) patients had gastroparesis. Mean GET in the gastroparesis group was 141 +/- 66 minutes compared to 24.53 +/- 10 minutes in the non gastroparesis group (p < 0.01). GET decreased by 72% amongst the patients who received cisapride compared to 23% in the placebo group (p < 0.001). Symptom scores also improved in the cisapride group; no adverse effects were noted. CONCLUSIONS: Cisapride improves the symptom score and the solid gastric emptying time in patients suffering from diabetic gastroparesis. SN - 0250-636X UR - https://www.unboundmedicine.com/medline/citation/10695417/Double_blind_controlled_trial_of_effect_of_cisapride_on_gastric_emptying_in_diabetics_ L2 - https://medlineplus.gov/diabeticnerveproblems.html DB - PRIME DP - Unbound Medicine ER -