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Salivary gland-specific gene expression in the malaria vector Anopheles gambiae.
Parassitologia. 1999 Sep; 41(1-3):483-7.P

Abstract

Molecular studies on the tissue-specific gene expression in the salivary glands of Anopheles gambiae may provide useful tools for the development of new strategies for the control of the most efficient malaria vector in the sub-Saharan Africa. We summarize here the results of a recent investigation focused on the isolation of secreted factors and putative receptors from the salivary glands of An. gambiae. Using the Signal Sequence Trap technique we have identified the first cDNAs specifically expressed in the An. gambiae salivary glands. Among these, four are exclusively expressed in female glands and encode factors presumably involved in blood-feeding, whereas two other cDNAs seem to be expressed both in male and in female glands and are likely implicated in sugar-feeding. Homologues of genes previously identified in the yellow fever mosquito Aedes aegypti, like the apyrase and D7, as well as novel salivary gland-specific cDNAs, were identified. The isolation and characterization of promoter sequences from the corresponding genes may prove useful for the expression of anti parasitic agents in the salivary glands of transgenic mosquitoes.

Authors+Show Affiliations

Istituto di Parassitologia, Fondazione Istituto Pasteur-Cenci Bolognetti, Università La Sapienza, Roma, Italy. b.arca@axcasp.caspur.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

10697906

Citation

Arcà, B, et al. "Salivary Gland-specific Gene Expression in the Malaria Vector Anopheles Gambiae." Parassitologia, vol. 41, no. 1-3, 1999, pp. 483-7.
Arcà B, Lombardo F, Capurro M, et al. Salivary gland-specific gene expression in the malaria vector Anopheles gambiae. Parassitologia. 1999;41(1-3):483-7.
Arcà, B., Lombardo, F., Capurro, M., della Torre, A., Spanos, L., Dimopoulos, G., Louis, C., James, A. A., & Coluzzi, M. (1999). Salivary gland-specific gene expression in the malaria vector Anopheles gambiae. Parassitologia, 41(1-3), 483-7.
Arcà B, et al. Salivary Gland-specific Gene Expression in the Malaria Vector Anopheles Gambiae. Parassitologia. 1999;41(1-3):483-7. PubMed PMID: 10697906.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Salivary gland-specific gene expression in the malaria vector Anopheles gambiae. AU - Arcà,B, AU - Lombardo,F, AU - Capurro,M, AU - della Torre,A, AU - Spanos,L, AU - Dimopoulos,G, AU - Louis,C, AU - James,A A, AU - Coluzzi,M, PY - 2000/3/4/pubmed PY - 2000/3/4/medline PY - 2000/3/4/entrez SP - 483 EP - 7 JF - Parassitologia JO - Parassitologia VL - 41 IS - 1-3 N2 - Molecular studies on the tissue-specific gene expression in the salivary glands of Anopheles gambiae may provide useful tools for the development of new strategies for the control of the most efficient malaria vector in the sub-Saharan Africa. We summarize here the results of a recent investigation focused on the isolation of secreted factors and putative receptors from the salivary glands of An. gambiae. Using the Signal Sequence Trap technique we have identified the first cDNAs specifically expressed in the An. gambiae salivary glands. Among these, four are exclusively expressed in female glands and encode factors presumably involved in blood-feeding, whereas two other cDNAs seem to be expressed both in male and in female glands and are likely implicated in sugar-feeding. Homologues of genes previously identified in the yellow fever mosquito Aedes aegypti, like the apyrase and D7, as well as novel salivary gland-specific cDNAs, were identified. The isolation and characterization of promoter sequences from the corresponding genes may prove useful for the expression of anti parasitic agents in the salivary glands of transgenic mosquitoes. SN - 0048-2951 UR - https://www.unboundmedicine.com/medline/citation/10697906/Salivary_gland_specific_gene_expression_in_the_malaria_vector_Anopheles_gambiae_ DB - PRIME DP - Unbound Medicine ER -