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Acquisition, extinction, and reinstatement of Pavlovian fear conditioning: the roles of the NMDA receptor and nitric oxide.
Brain Res. 2000 Feb 28; 857(1-2):66-70.BR

Abstract

The acquisition and extinction of Pavlovian conditioned fear have been shown to be mediated by the N-methyl-D-aspartate (NMDA) glutamate receptor. This study found that the NMDA antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten-5,10-imine maleate (MK-801) blocked the reinstatement of Pavlovian conditioned fear in rats. The role of nitric oxide (NO) in the acquisition and extinction of Pavlovian fear conditioning was also examined. L-NAME, an NO synthase inhibitor, failed to block the acquisition or extinction of Pavlovian fear conditioning. The results are discussed in the context of hierarchical associations and the array of NMDA and calcium mediated mechanisms of synaptic strengthening.

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Publisher Full Text

Authors+Show Affiliations

Johnson DM
Southeastern Louisiana University, Box 10304, Hammond, LA 70402, USA.
Baker JD
No affiliation info available
Azorlosa JL
No affiliation info available

MeSH

AnimalsAvoidance LearningConditioning, PsychologicalDizocilpine MaleateEnzyme InhibitorsExcitatory Amino Acid AntagonistsExtinction, PsychologicalFearNG-Nitroarginine Methyl EsterNitric OxideRatsRats, Sprague-DawleyReceptors, N-Methyl-D-Aspartate

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10700553

Citation

Johnson, D M., et al. "Acquisition, Extinction, and Reinstatement of Pavlovian Fear Conditioning: the Roles of the NMDA Receptor and Nitric Oxide." Brain Research, vol. 857, no. 1-2, 2000, pp. 66-70.
Johnson DM, Baker JD, Azorlosa JL. Acquisition, extinction, and reinstatement of Pavlovian fear conditioning: the roles of the NMDA receptor and nitric oxide. Brain Res. 2000;857(1-2):66-70.
Johnson, D. M., Baker, J. D., & Azorlosa, J. L. (2000). Acquisition, extinction, and reinstatement of Pavlovian fear conditioning: the roles of the NMDA receptor and nitric oxide. Brain Research, 857(1-2), 66-70.
Johnson DM, Baker JD, Azorlosa JL. Acquisition, Extinction, and Reinstatement of Pavlovian Fear Conditioning: the Roles of the NMDA Receptor and Nitric Oxide. Brain Res. 2000 Feb 28;857(1-2):66-70. PubMed PMID: 10700553.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acquisition, extinction, and reinstatement of Pavlovian fear conditioning: the roles of the NMDA receptor and nitric oxide. AU - Johnson,D M, AU - Baker,J D, AU - Azorlosa,J L, PY - 2000/3/4/pubmed PY - 2000/5/8/medline PY - 2000/3/4/entrez SP - 66 EP - 70 JF - Brain research JO - Brain Res VL - 857 IS - 1-2 N2 - The acquisition and extinction of Pavlovian conditioned fear have been shown to be mediated by the N-methyl-D-aspartate (NMDA) glutamate receptor. This study found that the NMDA antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten-5,10-imine maleate (MK-801) blocked the reinstatement of Pavlovian conditioned fear in rats. The role of nitric oxide (NO) in the acquisition and extinction of Pavlovian fear conditioning was also examined. L-NAME, an NO synthase inhibitor, failed to block the acquisition or extinction of Pavlovian fear conditioning. The results are discussed in the context of hierarchical associations and the array of NMDA and calcium mediated mechanisms of synaptic strengthening. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/10700553/Acquisition_extinction_and_reinstatement_of_Pavlovian_fear_conditioning:_the_roles_of_the_NMDA_receptor_and_nitric_oxide_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(99)02388-4 DB - PRIME DP - Unbound Medicine ER -