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A randomized controlled trial of a 3-year home exercise program in cystic fibrosis.
J Pediatr. 2000 Mar; 136(3):304-10.JPed

Abstract

OBJECTIVES

To evaluate the effects of a 3-year home exercise program on pulmonary function and exercise tolerance in mildly to moderately impaired patients with cystic fibrosis (CF) and to assess whether regular aerobic exercise is a realistic treatment option.

STUDY DESIGN

Seventy-two patients with CF (7-19 years) were randomly assigned to an exercise group (a minimum of 20 minutes of aerobic exercise, at a heart rate of approximately 150 beats/min, 3 times weekly) or a control group (usual physical activity participation). Pulmonary function, exercise tolerance, clinical status, hospitalizations, and compliance with therapy were monitored during scheduled visits to the hospital's CF clinic.

RESULTS

Sixty-five patients were included in the analyses. The control group demonstrated a greater annual decline in percent of predicted forced vital capacity compared with the exercise group (mean slope +/- SD, -2.42 +/- 4.15 vs -0.25 +/- 2.81; P =.02), with a similar trend for forced expiratory volume in 1 second (-3.47 +/- 4.93 vs -1.46 +/- 3. 55; P =.07). Patients remained compliant with the exercise program over the study period. An improved sense of well-being was reported with exercise.

CONCLUSIONS

Pulmonary function declined more slowly in the exercise group than in the control group, suggesting a benefit for patients with CF participating in regular aerobic exercise. Consistent compliance with the home exercise program and a self-reported positive attitude toward exercise provide further evidence of the feasibility and value of including an aerobic exercise program in the conventional treatment regimen of patients with CF.

Authors+Show Affiliations

Division of Respiratory Medicine, The Hospital for Sick Children, Departments of Paediatrics and Public Health Sciences, The University of Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

10700685

Citation

Schneiderman-Walker, J, et al. "A Randomized Controlled Trial of a 3-year Home Exercise Program in Cystic Fibrosis." The Journal of Pediatrics, vol. 136, no. 3, 2000, pp. 304-10.
Schneiderman-Walker J, Pollock SL, Corey M, et al. A randomized controlled trial of a 3-year home exercise program in cystic fibrosis. J Pediatr. 2000;136(3):304-10.
Schneiderman-Walker, J., Pollock, S. L., Corey, M., Wilkes, D. D., Canny, G. J., Pedder, L., & Reisman, J. J. (2000). A randomized controlled trial of a 3-year home exercise program in cystic fibrosis. The Journal of Pediatrics, 136(3), 304-10.
Schneiderman-Walker J, et al. A Randomized Controlled Trial of a 3-year Home Exercise Program in Cystic Fibrosis. J Pediatr. 2000;136(3):304-10. PubMed PMID: 10700685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized controlled trial of a 3-year home exercise program in cystic fibrosis. AU - Schneiderman-Walker,J, AU - Pollock,S L, AU - Corey,M, AU - Wilkes,D D, AU - Canny,G J, AU - Pedder,L, AU - Reisman,J J, PY - 2000/3/4/pubmed PY - 2000/4/15/medline PY - 2000/3/4/entrez SP - 304 EP - 10 JF - The Journal of pediatrics JO - J. Pediatr. VL - 136 IS - 3 N2 - OBJECTIVES: To evaluate the effects of a 3-year home exercise program on pulmonary function and exercise tolerance in mildly to moderately impaired patients with cystic fibrosis (CF) and to assess whether regular aerobic exercise is a realistic treatment option. STUDY DESIGN: Seventy-two patients with CF (7-19 years) were randomly assigned to an exercise group (a minimum of 20 minutes of aerobic exercise, at a heart rate of approximately 150 beats/min, 3 times weekly) or a control group (usual physical activity participation). Pulmonary function, exercise tolerance, clinical status, hospitalizations, and compliance with therapy were monitored during scheduled visits to the hospital's CF clinic. RESULTS: Sixty-five patients were included in the analyses. The control group demonstrated a greater annual decline in percent of predicted forced vital capacity compared with the exercise group (mean slope +/- SD, -2.42 +/- 4.15 vs -0.25 +/- 2.81; P =.02), with a similar trend for forced expiratory volume in 1 second (-3.47 +/- 4.93 vs -1.46 +/- 3. 55; P =.07). Patients remained compliant with the exercise program over the study period. An improved sense of well-being was reported with exercise. CONCLUSIONS: Pulmonary function declined more slowly in the exercise group than in the control group, suggesting a benefit for patients with CF participating in regular aerobic exercise. Consistent compliance with the home exercise program and a self-reported positive attitude toward exercise provide further evidence of the feasibility and value of including an aerobic exercise program in the conventional treatment regimen of patients with CF. SN - 0022-3476 UR - https://www.unboundmedicine.com/medline/citation/10700685/A_randomized_controlled_trial_of_a_3_year_home_exercise_program_in_cystic_fibrosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3476(00)12109-2 DB - PRIME DP - Unbound Medicine ER -