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Oral glutamine to alleviate radiation-induced oral mucositis: a pilot randomized trial.
Int J Radiat Oncol Biol Phys 2000; 46(3):535-9IJ

Abstract

PURPOSE

To evaluate the influence of oral glutamine on radiation-induced oral mucositis in the radiotherapy of head and neck cancer.

METHODS AND MATERIALS

From July 1997 through June 1998, 17 patients with head and neck cancer receiving primary or adjuvant irradiation were randomized to either glutamine suspension (16 g in 240 ml normal saline) (n = 8) or placebo (normal saline) (n = 9) arm. Patients were instructed to swish the test solutions (30 ml) four times per day. All patients received half-mouth irradiation at least. Patients were treated 1.8 Gy per fraction daily, 5 days a week. We evaluated the grading of oral mucositis daily fraction at each day of treatment until 45 Gy/25 fractions. World Health Organization (WHO) step analgesic medication and body weight change were compared between the two arms.

RESULTS

The duration of objective oral mucositis > or = Grade 1 (p = 0.0097), Grade 2 (p = 0.0232), and Grade 3 (p = 0.0168) was shorter in the glutamine arm. Mean maximum grade of objective oral mucositis was less severe in the glutamine arm (1.6 vs. 2.6) (p = 0.0058). Glutamine did not reduce the duration and severity of subjective oral mucositis except for duration > or = Grade 3 (p = 0.0386). In the analysis of mean maximum WHO step of analgesic medication, there was no statistical difference (p = 0.5374) between the two arms. Mean body weight change was also not significantly different (p = 0.8070).

CONCLUSIONS

Oral glutamine may significantly reduce the duration and severity of objective oral mucositis during radiotherapy. It may shorten the duration of > or = Grade 3 subjective mucositis.

Authors+Show Affiliations

Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Niao-Sung Hsiang, Kaohsiung Hsien, Taiwan. hey1200@ksts.seed.net.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

10701731

Citation

Huang, E Y., et al. "Oral Glutamine to Alleviate Radiation-induced Oral Mucositis: a Pilot Randomized Trial." International Journal of Radiation Oncology, Biology, Physics, vol. 46, no. 3, 2000, pp. 535-9.
Huang EY, Leung SW, Wang CJ, et al. Oral glutamine to alleviate radiation-induced oral mucositis: a pilot randomized trial. Int J Radiat Oncol Biol Phys. 2000;46(3):535-9.
Huang, E. Y., Leung, S. W., Wang, C. J., Chen, H. C., Sun, L. M., Fang, F. M., ... Hsiung, C. Y. (2000). Oral glutamine to alleviate radiation-induced oral mucositis: a pilot randomized trial. International Journal of Radiation Oncology, Biology, Physics, 46(3), pp. 535-9.
Huang EY, et al. Oral Glutamine to Alleviate Radiation-induced Oral Mucositis: a Pilot Randomized Trial. Int J Radiat Oncol Biol Phys. 2000 Feb 1;46(3):535-9. PubMed PMID: 10701731.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral glutamine to alleviate radiation-induced oral mucositis: a pilot randomized trial. AU - Huang,E Y, AU - Leung,S W, AU - Wang,C J, AU - Chen,H C, AU - Sun,L M, AU - Fang,F M, AU - Yeh,S A, AU - Hsu,H C, AU - Hsiung,C Y, PY - 2000/3/4/pubmed PY - 2000/3/18/medline PY - 2000/3/4/entrez SP - 535 EP - 9 JF - International journal of radiation oncology, biology, physics JO - Int. J. Radiat. Oncol. Biol. Phys. VL - 46 IS - 3 N2 - PURPOSE: To evaluate the influence of oral glutamine on radiation-induced oral mucositis in the radiotherapy of head and neck cancer. METHODS AND MATERIALS: From July 1997 through June 1998, 17 patients with head and neck cancer receiving primary or adjuvant irradiation were randomized to either glutamine suspension (16 g in 240 ml normal saline) (n = 8) or placebo (normal saline) (n = 9) arm. Patients were instructed to swish the test solutions (30 ml) four times per day. All patients received half-mouth irradiation at least. Patients were treated 1.8 Gy per fraction daily, 5 days a week. We evaluated the grading of oral mucositis daily fraction at each day of treatment until 45 Gy/25 fractions. World Health Organization (WHO) step analgesic medication and body weight change were compared between the two arms. RESULTS: The duration of objective oral mucositis > or = Grade 1 (p = 0.0097), Grade 2 (p = 0.0232), and Grade 3 (p = 0.0168) was shorter in the glutamine arm. Mean maximum grade of objective oral mucositis was less severe in the glutamine arm (1.6 vs. 2.6) (p = 0.0058). Glutamine did not reduce the duration and severity of subjective oral mucositis except for duration > or = Grade 3 (p = 0.0386). In the analysis of mean maximum WHO step of analgesic medication, there was no statistical difference (p = 0.5374) between the two arms. Mean body weight change was also not significantly different (p = 0.8070). CONCLUSIONS: Oral glutamine may significantly reduce the duration and severity of objective oral mucositis during radiotherapy. It may shorten the duration of > or = Grade 3 subjective mucositis. SN - 0360-3016 UR - https://www.unboundmedicine.com/medline/citation/10701731/Oral_glutamine_to_alleviate_radiation_induced_oral_mucositis:_a_pilot_randomized_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0360301699004022 DB - PRIME DP - Unbound Medicine ER -